The elucidation of the mechanism of the development and progression of gliomas due to epigenetic deregulation and the identification of therapeutic targets

• Project/Area Number: 17H04300
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kumamoto University
• Principal Investigator: Mukasa Akitake 熊本大学, 大学院生命科学研究部(医), 教授 (90463869)
• Co-Investigator(Kenkyū-buntansha): 永江 玄太 東京大学, 先端科学技術研究センター, 講師 (10587348) ; 篠島 直樹 熊本大学, 病院, 講師 (50648269) ; 田中 將太 東京大学, 医学部附属病院, 助教 (80643725)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
• Keywords: エピゲノム / メチル化 / ヒドロキシメチル化 / 腫瘍発生 / 悪性化 / グリオーマ

Outline of Final Research Achievements

The epigenetic deregulation of gliomas was studied to reveal the mechanism of gliomagenesis. Changes in 5-hydroxymethylcytosine (5-hmc), which accompany the deregulation of DNA methylation, were analyzed using the Oxidative Bisulfite (OxBS) method. Analysis of changes in 5-hmc during the malignant progression of IDH-mutant gliomas revealed actively demethylated regions (AcDRs) that are potentially associated with malignant changes. Further analysis demonstrated these AcDRs to be related to common transcription factors and that these AcDRs regulate the expression of cancer-related genes.

Academic Significance and Societal Importance of the Research Achievements

近年注目を浴びているエピゲノム制御破綻に起因する腫瘍発生機構のうち、特にこれまであまり解析されていないハイドロキシメチルシトシンの変化を測定することで明らかにした。また、今回Tab-chip法に代わり使用法を確立し有用性を示したOxBS法は、今後の研究にも役立てられると考える。また、神経膠腫（グリオーマ）悪性化に伴う脱メチル化の一部では、能動的脱メチル化が生じていることを明らかにし、その制御機構解析により、新たな腫瘍化機構解明と治療法開発につながる可能性のあるデータを創出した。

Research Products

• [Journal Article] An initial experience of machine learning based on multi-sequence texture parameters in magnetic resonance imaging to differentiate glioblastoma from brain metastases (2020)
  • Author(s): Tateishi Machiko、Nakaura Takeshi、Kitajima Mika、Uetani Hiroyuki、Nakagawa Masataka、Inoue Taihei、Kuroda Jun-ichiro、Mukasa Akitake、Yamashita Yasuyuki
  • Journal Title: Journal of the Neurological Sciences Volume: 410 Pages: 116514-116514
  • DOI: 10.1016/j.jns.2019.116514
  • Peer Reviewed
• [Journal Article] Reduced Neoantigen Expression Revealed by Longitudinal Multiomics as a Possible Immune Evasion Mechanism in Glioma. (2019)
  • Author(s): Nejo T, Matsushita H, Karasaki T, Nomura M, Saito K, Tanaka S, Takayanagi S, Hana T, Takahashi S, Kitagawa Y, Koike T, Kobayashi Y, Nagae G, Yamamoto S, Ueda H, Tatsuno K, Narita Y, Nagane M, Ueki K, Nishikawa R, Aburatani H, Mukasa A, Saito N, Kakimi K.
  • Journal Title: Cancer Immunol Res Volume: in press Issue: 7 Pages: 1148-1161
  • DOI: 10.1158/2326-6066.cir-18-0599
  • Peer Reviewed
• [Journal Article] Intraoperative quantification of meningioma cell proliferation potential using rapid flow cytometry reveals intratumoral heterogeneity (2019)
  • Author(s): Oya Soichi、Yoshida Shinsuke、Tsuchiya Tsukasa、Fujisawa Naoaki、Mukasa Akitake、Nakatomi Hirofumi、Saito Nobuhito、Matsui Toru
  • Journal Title: Cancer Medicine Volume: 8 Issue: 6 Pages: 2793-2801
  • DOI: 10.1002/cam4.2178
  • Peer Reviewed / Open Access
• [Journal Article] Eribulin penetrates brain tumor tissue and prolongs survival of mice harboring intracerebral glioblastoma xenografts (2019)
  • Author(s): Takahashi Masamichi、Miki Shunichiro、Fujimoto Kenji、Fukuoka Kohei、Matsushita Yuko、Maida Yoshiko、Yasukawa Mami、Hayashi Mitsuhiro、Shinkyo Raku、Kikuchi Kiyomi、Mukasa Akitake、Nishikawa Ryo、Tamura Kenji、Narita Yoshitaka、Hamada Akinobu、Masutomi Kenkichi、Ichimura Koichi
  • Journal Title: Cancer Science Volume: 110 Issue: 7 Pages: 2247-2257
  • DOI: 10.1111/cas.14067
  • Peer Reviewed / Open Access
• [Journal Article] Radiomics analysis for glioma malignancy evaluation using diffusion kurtosis and tensor imaging (2019)
  • Author(s): Takahashi S, Takahashi W, Tanaka S, Haga A, Nakamoto T, Suzuki Y, Mukasa A, Takayanagi S, Kitagawa Y, Hana T, Nejo T, Nomura M, Nakagawa K, Saito N
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 105 Issue: 4 Pages: 784-791
  • DOI: 10.1016/j.ijrobp.2019.07.011
  • Peer Reviewed
• [Journal Article] Integrated clinical, histopathological, and molecular data analysis of 190 central nervous system germ cell tumors from the iGCT Consortium (2019)
  • Author(s): Takami H, Fukuoka K, Fukushima S, Nakamura T, Mukasa A, Saito N, Yanagisawa T, Nakamura H, Sugiyama K, Kanamori M, Tominaga T, Maehara T, Nakada M, Kanemura Y, Asai A, et al.
  • Journal Title: Neuro-Oncology Volume: 21 Issue: 12 Pages: 1565-1577
  • DOI: 10.1093/neuonc/noz139
  • Peer Reviewed
• [Journal Article] 2-Methylthio Conversion of N6-Isopentenyladenosine in Mitochondrial tRNAs by CDK5RAP1 Promotes the Maintenance of Glioma-Initiating Cells (2019)
  • Author(s): Yamamoto Takahiro、Fujimura Atsushi、Wei Fan-Yan、Shinojima Naoki、Kuroda Jun-ichiro、Mukasa Akitake、Tomizawa Kazuhito
  • Journal Title: iScience Volume: 21 Pages: 42-56
  • DOI: 10.1016/j.isci.2019.10.012
  • NAID: 120006816645
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of malignant glioma grades using contrast-enhanced T1-weighted and T2-weighted magnetic resonance images based on a radiomic analysis (2019)
  • Author(s): Nakamoto Takahiro、Takahashi Wataru、Haga Akihiro、Takahashi Satoshi、Kiryu Shigeru、Nawa Kanabu、Ohta Takeshi、Ozaki Sho、Nozawa Yuki、Tanaka Shota、Mukasa Akitake、Nakagawa Keiichi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 19411-19423
  • DOI: 10.1038/s41598-019-55922-0
  • NAID: 120006875662
  • Peer Reviewed / Open Access
• [Journal Article] Intratumoural immune cell landscape in germinoma reveals multipotent lineages and exhibits prognostic significance (2019)
  • Author(s): Takami H, Fukushima S, Aoki K, Satomi K, Narumi K, Hama N, Matsushita Y, Fukuoka K, Yamasaki K, Nakamura T, Mukasa A, Saito N, Suzuki T, Yanagisawa T, Nakamura H, Sugiyama K, Tamura K, Maehara T, Nakada M, Nonaka M, Asai A, et al.
  • Journal Title: Neuropathology and Applied Neurobiology Volume: - Issue: 2 Pages: 111-124
  • DOI: 10.1111/nan.12570
  • Peer Reviewed / Open Access
• [Journal Article] Spray Fluorescent Probes for Fluorescence-Guided Neurosurgery (2019)
  • Author(s): Kitagawa Yosuke、Tanaka Shota、Kuriki Yugo、Yamamoto Kyoko、Ogasawara Akira、Nejo Takahide、Matsuura Reiko、Koike Tsukasa、Hana Taijun、Takahashi Satoshi、Nomura Masashi、Takayanagi Shunsaku、Mukasa Akitake、Kamiya Mako、Urano Yasuteru、Saito Nobuhito
  • Journal Title: Frontiers in Oncology Volume: 9 Pages: 727-727
  • DOI: 10.3389/fonc.2019.00727
  • Peer Reviewed / Open Access
• [Journal Article] 悪性脳腫瘍治療の未来 (2019)
  • Author(s): 武笠晃丈
  • Journal Title: Annual Review 神経 2019/中外医学社 Volume: - Pages: 191-197
• [Journal Article] Diffuse midline glioma (2019)
  • Author(s): 武笠晃丈
  • Journal Title: 脳神経外科学レビュー/総合医学社 Volume: - Pages: 10-15
• [Journal Article] 神経膠腫グレードⅡ/Ⅲの治療戦略 (2019)
  • Author(s): 武笠晃丈
  • Journal Title: 脳神経外科ジャーナル Jpn Neurosurg Volume: 28 Pages: 699-704
  • NAID: 130007751021
  • Peer Reviewed
• [Journal Article] Pattern of FDG and MET Distribution in High- and Low-Grade Gliomas on PET Images. (2019)
  • Author(s): Takahashi M, Soma T, Mukasa A, Tanaka S, Yanagisawa S, Momose T.
  • Journal Title: Clinical Nuclear Medicine Volume: － Issue: 4 Pages: 265-271
  • DOI: 10.1097/rlu.0000000000002460
  • Peer Reviewed
• [Journal Article] DNA demethylation is associated with malignant progression of lower-grade gliomas (2019)
  • Author(s): Nomura Masashi、Saito Kuniaki、Aihara Koki、Nagae Genta、Yamamoto Shogo、Tatsuno Kenji、Ueda Hiroki、Fukuda Shiro、Umeda Takayoshi、Tanaka Shota、…、Narita Yoshitaka、Nagane Motoo、Nishikawa Ryo、Ueki Keisuke、Saito Nobuhito、Aburatani Hiroyuki、Mukasa Akitake
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 1903-1903
  • DOI: 10.1038/s41598-019-38510-0
  • Peer Reviewed / Open Access
• [Journal Article] Maffucci syndrome complicated by three different central nervous system tumors sharing an IDH1 R132C mutation: case report (2019)
  • Author(s): Nejo Takahide、Tanaka Shota、Ikemura Masako、Nomura Masashi、Takayanagi Shunsaku、Shin Masahiro、Ushiku Tetsuo、Shibahara Junji、Saito Nobuhito、Mukasa Akitake
  • Journal Title: Journal of Neurosurgery Volume: 131 Issue: 6 Pages: 1829-1834
  • DOI: 10.3171/2018.6.jns18729
  • Peer Reviewed
• [Journal Article] Oligodendrocyte Progenitor Cells and Macrophages/Microglia Produce Glioma Stem Cell Niches at the Tumor Border. (2018)
  • Author(s): Hide T, Komohara Y, Miyasato Y, Nakamura H, Makino K, Takeya M, Kuratsu JI, Mukasa A, Yano S.
  • Journal Title: EBioMedicine. Volume: 30 Pages: 94-104
  • DOI: 10.1016/j.ebiom.2018.02.024
  • Peer Reviewed / Open Access
• [Journal Article] IDH-mutated astrocytomas with 19q-loss constitute a subgroup that confers better prognosis (2018)
  • Author(s): Otani Ryohei、Uzuka Takeo、Higuchi Fumi、Matsuda Hadzki、Nomura Masashi、Tanaka Shota、Mukasa Akitake、Ichimura Koichi、Kim Phyo、Ueki Keisuke
  • Journal Title: Cancer Science Volume: 109 Issue: 7 Pages: 2327-2335
  • DOI: 10.1111/cas.13635
  • Peer Reviewed / Open Access
• [Journal Article] Concomitant administration of radiation with eribulin improves the survival of mice harboring intracerebral glioblastoma. (2018)
  • Author(s): Miki S, Imamichi S, Fujimori H, Tomiyama A, Fujimoto K, Satomi K, Matsushita Y, Matsuzaki S, Takahashi M, Ishikawa E, Yamamoto T, Matsumura A, Mukasa A, Nishikawa R, Masutomi K, Narita Y, Masutani M, Ichimura K.
  • Journal Title: Cancer Sci Volume: 109 Issue: 7 Pages: 2275-2285
  • DOI: 10.1111/cas.13637
  • NAID: 120007133981
  • Peer Reviewed / Open Access
• [Journal Article] SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity (2018)
  • Author(s): Funato K, Hayashi T, Echizen K, Negishi L, Shimizu N, Koyama-Nasu R, Nasu-Nishimura Y, Morishita Y, Tabar V, Todo T, Ino Y, Mukasa A, Saito N & Akiyama T.
  • Journal Title: EMBO Reports Volume: 19 Issue: 11 Pages: 45587-45587
  • DOI: 10.15252/embr.201745587
  • Peer Reviewed / Open Access
• [Journal Article] 脳腫瘍のゲノム診療に向けて (2018)
  • Author(s): 武笠 晃丈
  • Journal Title: Clinical Neuroscience Volume: 36 Pages: 539-542
• [Journal Article] 小脳神経膠腫 (2018)
  • Author(s): 野村 昌志, 武笠 晃丈
  • Journal Title: Clinical Neuroscience Volume: 36 Pages: 558-561
• [Journal Article] Clinical significance of polyglutamylation in primary central nervous system lymphoma (2018)
  • Author(s): Shinojima Naoki、Fujimoto Kenji、Makino Keishi、Todaka Kohei、Yamada Kazumichi、Mikami Yoshiki、Oda Kazutaka、Nakamura Kazumi、Jono Hirofumi、Kuratsu Jun-ichi、Nakamura Hideo、Yano Shigetoshi、Mukasa Akitake
  • Journal Title: Acta Neuropathologica Communications Volume: 6 Issue: 1 Pages: 15-15
  • DOI: 10.1186/s40478-018-0522-4
  • Peer Reviewed / Open Access
• [Journal Article] 神経膠腫の不均一性による治療抵抗性とその治療戦略 (2018)
  • Author(s): 武笠 晃丈
  • Journal Title: 実験医学 Volume: 36 Pages: 307-313
• [Journal Article] Genome-wide DNA methylation profiles identifies primary central nervous system lymphomas as a distinct entity from systemic diffuse large B-cell lymphomas (2017)
  • Author(s): Nakamura T, Yamashita S, Fukumura K, Tanaka K, Nagane M, Narita Y, Mano H, Ushijima T, Ichimura K
  • Journal Title: Acta Neuropathol Volume: 133 Issue: 2 Pages: 321-324
  • DOI: 10.1007/s00401-016-1664-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An automated voxel-based method for calculating the reference value for a brain tumour metabolic index using 18F-FDG PET and 11C-Methionine PET. (2017)
  • Author(s): Takahashi, Soma T, Mukasa A, Koyama, Arai T, Momose T.
  • Journal Title: Ann Nucl Med Volume: 31 Issue: 3 Pages: 250-259
  • DOI: 10.1007/s12149-017-1153-8
  • Peer Reviewed / Open Access
• [Journal Article] Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system. (2017)
  • Author(s): Takayanagi S, Mukasa A, Tanaka S, Nomura M, Omata M, Yanagisawa S, Yamamoto S, Ichimura K, Nakatomi H, Ueki K, Aburatani H, Saito N
  • Journal Title: Neuro Oncol. Volume: 印刷中 Issue: 9 Pages: 1-7
  • DOI: 10.1093/neuonc/nox034
  • Peer Reviewed / Open Access
• [Journal Article] Brachyury gene copy number gain and activation of the PI3K/Akt pathway: association with upregulation of oncogenic Brachyury expression in skull base chordoma (2017)
  • Author(s): Otani Ryohei、Mukasa Akitake、Shin Masahiro、Omata Mayu、Takayanagi Shunsaku、Tanaka Shota、Ueki Keisuke、Saito Nobuhito
  • Journal Title: Journal of Neurosurgery Volume: なし Issue: 5 Pages: 1-10
  • DOI: 10.3171/2016.12.jns161444
  • Peer Reviewed
• [Journal Article] Distinct molecular profile of diffuse cerebellar gliomas (2017)
  • Author(s): Nomura M, Mukasa A, Nagae G, Yamamoto S, Tatsuno K, Ueda H, Fukuda S, Umeda T, Suzuki T, Otani R, Kobayashi K, Maruyama T, Tanaka S, Takayanagi S, Nejo T, Takahashi S, Ichimura K, Nakamura T, Muragaki Y, Narita Y, Nagane M, Ueki K, Nishikawa R, Shibahara J, Aburatani H, Saito N
  • Journal Title: Acta Neuropathologica Volume: 134 Issue: 6 Pages: 941-956
  • DOI: 10.1007/s00401-017-1771-1
  • Peer Reviewed / Open Access
• [Journal Article] Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation (2017)
  • Author(s): Takai Keisuke、Tanaka Shota、Sota Takashi、Mukasa Akitake、Komori Takashi、Taniguchi Makoto
  • Journal Title: World Neurosurgery Volume: 108 Pages: 991.e13-991.e16
  • DOI: 10.1016/j.wneu.2017.08.142
  • Peer Reviewed
• [Journal Article] Identification of a novel fusion gene HMGA2-EGFR in glioblastoma (2017)
  • Author(s): Komuro Akiyoshi、Raja Erna、Iwata Caname、Soda Manabu、Isogaya Kazunobu、Yuki Keiko、Ino Yasushi、Morikawa Masato、Todo Tomoki、Aburatani Hiroyuki、Suzuki Hiromichi、Ranjit Melissa、Natsume Atsushi、Mukasa Akitake、Saito Nobuhito、Okada Hitoshi、Mano Hiroyuki、Miyazono Kohei、Koinuma Daizo
  • Journal Title: International Journal of Cancer Volume: 142 Issue: 8 Pages: 1627-1639
  • DOI: 10.1002/ijc.31179
  • Peer Reviewed / Open Access
• [Journal Article] Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack (2017)
  • Author(s): Yoshida Y, Wang H, Hiwasa T, Machida T, Takiguchi M, Iwadate Y, et al.
  • Journal Title: Oncotarget Volume: 9 Issue: 3 Pages: 8836-8848
  • DOI: 10.1007/s11060-018-2831-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The significance of histone H3 K27M mutation in brain tumors (2017)
  • Author(s): 武笠 晃丈
  • Journal Title: Progress in Neuro-Oncology Volume: 24 Issue: 1 Pages: 7-17
  • DOI: 10.11452/neurooncology.24.1_7
  • NAID: 130005868650
  • ISSN: 1880-0742, 2187-0551
  • Peer Reviewed
• [Presentation] 脳腫瘍の診断から治療まで 脳神経外科治療―手術並びに化学療法を中心に (2019)
  • Author(s): 武笠 晃丈
  • Organizer: 第78回日本医学放射線学会総会
  • Invited
• [Presentation] 膠芽腫に対する手術治療の限界と今後の可能性 (2019)
  • Author(s): 武笠 晃丈
  • Organizer: 第39回日本脳神経外科コングレス総会
  • Invited
• [Presentation] 脳腫瘍遺伝子解析の最近のトレンド (2019)
  • Author(s): 武笠 晃丈
  • Organizer: 第20回日本分子脳神経外科学会
  • Invited
• [Presentation] Therapeutic strategies based on temporal and spatial heterogeneity of gliomas (2019)
  • Author(s): Akitake Mukasa
  • Organizer: 第16回Asian Society for Neuro-Oncology
  • Int'l Joint Research / Invited
• [Presentation] グリオーマの分子プロファイルの多様性からみた標的療法の課題 (2019)
  • Author(s): 武笠 晃丈
  • Organizer: 第78回日本脳神経外科学会 学術総会
• [Presentation] 脳腫瘍と遺伝子変異：主に神経膠腫 (2019)
  • Author(s): 武笠 晃丈
  • Organizer: 第55回日本医学放射線学会秋季臨床大会
  • Invited
• [Presentation] Glioma grade II III の治療戦略 (2018)
  • Author(s): 武笠晃丈
  • Organizer: 第38回日本脳神経外科コングレス総会
  • Invited
• [Presentation] Molecular characteristics of diffuse cerebellar glioma (2018)
  • Author(s): Mukasa A, Nomura M, Nagae G, Yamamoto S, Tatsuno K, Ueda H, Fukuda S, Umeda T, Suzuki T, Otani R, Kobayashi K, Maruyama T, Tanaka S, Takayanagi S, Nejo T, Takahashi S, Ichimura K, Nakamura T, Muragaki Y, Narita Y, Nagane M, Ueki K, Nishikawa R, Shibahara J, Aburatani H, Saito N
  • Organizer: The 22nd International Conference on Brain Tumor Research & Therapy (ICBTRT)
  • Int'l Joint Research / Invited
• [Presentation] Principles of glioma surgery in adults (2018)
  • Author(s): Akitake Mukasa
  • Organizer: The 27th Society of Neurosurgeons of South Africa Congress 2018
  • Int'l Joint Research / Invited
• [Presentation] Glioma: What does the average neurosurgeon need to know about current progress in molecular biology and how will this affect our treatment strategies? (2018)
  • Author(s): Akitake Mukasa
  • Organizer: The 27th Society of Neurosurgeons of South Africa Congress 2018
  • Int'l Joint Research / Invited
• [Presentation] 組織・細胞形態と分子プロファイルの多様性から考える脳腫瘍治療戦略 (2018)
  • Author(s): 武笠晃丈
  • Organizer: 第59回 日本組織細胞化学会 総会・学術集会
  • Invited
• [Presentation] マルチモダリティー時代のグリオーマ治療戦略 (2018)
  • Author(s): 武笠晃丈
  • Organizer: 第23回 日本脳腫瘍の外科学会
  • Invited
• [Presentation] 脳腫瘍のゲノム医療 (2018)
  • Author(s): 武笠晃丈
  • Organizer: 第77回 日本脳神経外科学会
  • Invited
• [Presentation] 腫瘍の分子病態と治療との関連から考える皮膚疾患 (2018)
  • Author(s): 武笠晃丈
  • Organizer: 第225回 日本皮膚科学会 熊本地方会
  • Invited
• [Presentation] 多様なグリオーマに対する precision medicine の可能性と課題 (2018)
  • Author(s): 武笠晃丈
  • Organizer: 第13回 脳腫瘍の基礎シンポジウム
  • Invited
• [Presentation] The characteristics of molecular profile changes in recurrent lower grade gliomas and their implication for therapeutic strategy (2017)
  • Author(s): Akitake Mukasa, Kuniaki Saito, Shota Tanaka, Shunsaku Takayanagi,Yoshitaka Narita, Motoo Nagane, Keisuke Ueki, Ryo Nishikawa, Hiroyuki Aburatani, Nobuhito Saito
  • Organizer: 5th Quadrennial Meeting of the World Federation of Neuro-Oncology Societies
  • Int'l Joint Research
• [Presentation] Spatial Heterogeneity of Molecular Profiles in Gliomas and its Implications for Cell-of-Origin and Targeted Therapy (2017)
  • Author(s): Akitake Mukasa
  • Organizer: The 72nd Fujihara Seminar
  • Int'l Joint Research / Invited
• [Presentation] Genetic and epigenetic stability of oligodendrogliomas at recurrence (2017)
  • Author(s): Akitake Mukasa, Koki Aihara, Masashi Nomura, Shota Tanaka, Junji Shibahara, Yoshitaka Narita, Motoo Nagane, Ryo Nishikawa, Keisuke Ueki, Hiroyuki Aburatani, Nobuhito Saito
  • Organizer: The 14th Meeting of the Asian Society for Neuro-Oncology
  • Int'l Joint Research
• [Presentation] Characteristic molecular profile changes in primary and recurrent gliomas depending on their histopathology (2017)
  • Author(s): Akitake Mukasa, Masashi Nomura, Kuniaki Saito, Koki Aihara, Genta Nagae, Takahide Nejo, Shota Tanaka, Shunsaku Takayanagi, Satoshi Takahashi, Mayu Omata, Taishi Nakamura, Yoshitaka Narita, Yoshihiro Muragaki, Motoo Nagane, Keisuke Ueki, Ryo Nishikawa, Hiroyuki Aburatani, Nobuhito Saito
  • Organizer: 22nd Annual Meeting of the Society of Neuro-Oncology
  • Int'l Joint Research
• [Presentation] 再発 oligodendroglioma の ゲノム・エピゲノムの安定性 (2017)
  • Author(s): 武笠晃丈、相原功輝、野村昌志、田中將太、高柳俊作、永根基雄、成田善孝、植木敬介、油谷浩幸、斉藤延人
  • Organizer: 第34回日本脳腫瘍病理学会
• [Presentation] Integrated and comparative multi-omics analysis of primary and recurrent glioma and its clinical application (2017)
  • Author(s): Akitake Mukasa, Masashi Nomura, Kuniaki Saito, Koki Aihara, Genta Nagae, Takahide Nejo, Shunsaku Takayanagi, Shota Tanaka, Taishi Nakamura, Yoshitaka Narita, Yoshihiro Muragaki, Motoo Nagane, Keisuke Ueki, Ryo Nishikawa, Hiroyuki Aburatani, Nobuhito Saito
  • Organizer: 第76回日本脳神経外科学会
• [Presentation] 初発・再発神経膠腫のマルチオミクス比較解析から考える悪性転化機序とその治療戦略 (2017)
  • Author(s): 武笠晃丈、野村昌志、齊藤邦昭、相原功輝、永江玄太、上田 宏生、山本 尚吾、辰野 健二、根城 尭英、高橋 慧、高柳俊作、田中將太、花 大洵、北川陽介、中村大志、成田善孝、村垣善浩、永根基雄、西川 亮、植木敬介、油谷浩幸、斉藤延人
  • Organizer: 第35日本脳腫瘍学会