• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanisms of pathological bone formation and potential applications

Research Project

Project/Area Number 17H04317
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionSaitama Medical University

Principal Investigator

KATAGIRI TAKENOBU  埼玉医科大学, 医学部, 教授 (80245802)

Co-Investigator(Kenkyū-buntansha) 自見 英治郎  九州大学, 歯学研究院, 教授 (40276598)
仲地 ゆたか  熊本大学, 大学院生命科学研究部(医), 助教 (10522097)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords骨形成 / 石灰化 / BMP / Wnt / 異所性骨化 / 筋組織 / 骨組織 / シグナル伝達 / 骨格筋 / 再生医学 / 分化 / 前駆細胞
Outline of Final Research Achievements

We examined molecular mechanisms of bone formation especially in pathological conditions using genetically engineered mice and cultured cels. We found a novel axis of transcriptional coactivator Smad4 - growth factor Wnt7b as an important pathway on bone formation in vivo. In addition, we examined a murine in vivo model of trauma-induced hard tissue formation in skeletal muscle tissue. This event was different from bone formation and was precipitation of apatite crystals.

Academic Significance and Societal Importance of the Research Achievements

本研究で明らかとなった転写共役因子Smad4を介したWnt7bの発現制御による骨形成の調節機構は、新しい骨形成制御機構である。この骨形成調節機構を人為的に制御できる生理活性物質は、新しい骨形成制御分子として、骨粗鬆症などの疾患い応用できる可能性がある。また、本制御系の異常が、発症原因が不明の骨関連疾患の一因となる可能性も示唆される。筋組織における外傷性の硬組織形成モデルの解析から、形成された組織は骨や軟骨ではなく、リンとカルシウムの結晶析出であることが判明した。従って、予防や治療を考える上で、骨形成は異なるアプローチが必要であることが明らかとなった。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (65 results)

All 2020 2019 2018 2017 Other

All Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Open Access: 8 results) Presentation (49 results) (of which Int'l Joint Research: 29 results,  Invited: 20 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Functional characterization of a unique mutant of ALK2, p.K400E, that is associated with a skeletal disorder, diffuse idiopathic skeletal hyperostosis2020

    • Author(s)
      Tsukamoto Sho、Kuratani Mai、Katagiri Takenobu
    • Journal Title

      Bone

      Volume: 137 Pages: 115410-115410

    • DOI

      10.1016/j.bone.2020.115410

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibrodysplasia ossificans progressiva: Review and research activities in Japan2020

    • Author(s)
      Haga Nobuhiko、Nakashima Yasuharu、Kitoh Hiroshi、Kamizono Junji、Katagiri Takenobu、Saijo Hideto、Tsukamoto Sho、Shinoda Yusuke、Sawada Ryoko、Nakahara Yasuo
    • Journal Title

      Pediatrics International

      Volume: 62 Issue: 1 Pages: 3

    • DOI

      10.1111/ped.14065

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation2019

    • Author(s)
      Sone Takefumi、Shin Masashi、Ouchi Takehito、Sasanuma Hiroki、Miyamoto Arei、Ohte Satoshi、Tsukamoto Sho、Nakanishi Mahito、Okano Hideyuki、Katagiri Takenobu、Mitani Kohnosuke
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 9705-9705

    • DOI

      10.1038/s41598-019-46105-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery of Heterotopic Bone-Inducing Activity in Hard Tissues and the TGF-β Superfamily2018

    • Author(s)
      Katagiri Takenobu、Tsukamoto Sho、Nakachi Yutaka、Kuratani Mai
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 11 Pages: 3586-3586

    • DOI

      10.3390/ijms19113586

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent Topics in Fibrodysplasia Ossificans Progressiva2018

    • Author(s)
      Katagiri Takenobu、Tsukamoto Sho、Nakachi Yutaka、Kuratani Mai
    • Journal Title

      Endocrinology and Metabolism

      Volume: 33 Issue: 3 Pages: 331-331

    • DOI

      10.3803/enm.2018.33.3.331

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A potential novel option for cancer immunotherapy - TLR7 stimulation inhibits malignant melanoma bone invasion2018

    • Author(s)
      Katagiri Takenobu
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 61 Pages: 31792-3179

    • DOI

      10.18632/oncotarget.25872

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMPR2 inhibits activin and BMP signaling via wild-type ALK22018

    • Author(s)
      Olsen Oddrun Elise、Sankar Meenu、Elsaadi Samah、Hella Hanne、Buene Glenn、Darvekar Sagar Ramesh、Misund Kristine、Katagiri Takenobu、Knaus Petra、Holien Toril
    • Journal Title

      Journal of Cell Science

      Volume: 131 Issue: 11 Pages: 213512-213512

    • DOI

      10.1242/jcs.213512

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders2018

    • Author(s)
      Machiya Aiko、Tsukamoto Sho、Ohte Satoshi、Kuratani Mai、Fujimoto Mai、Kumagai Keigo、Osawa Kenji、Suda Naoto、Bullock Alex N.、Katagiri Takenobu
    • Journal Title

      Bone

      Volume: 111 Pages: 101-108

    • DOI

      10.1016/j.bone.2018.03.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heterotopic bone induction via BMP signaling: Potential therapeutic targets for fibrodysplasia ossificans progressiva2018

    • Author(s)
      Katagiri Takenobu、Tsukamoto Sho、Kuratani Mai
    • Journal Title

      Bone

      Volume: 109 Pages: 241-250

    • DOI

      10.1016/j.bone.2017.07.024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular mechanisms for activation of mutant Activin receptor-like kinase 2 in fibrodysplasia ossificans progressiva.2017

    • Author(s)
      Fujimoto M, Suda N, and Katagiri T
    • Journal Title

      Journal of Oral Biosciences

      Volume: 59 Pages: 121-126

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Scopranones with Two Atypical Scooplike Moieties Produced by Streptomyces sp. BYK-110382017

    • Author(s)
      Uchida Ryuji、Lee Daiki、Suwa Ibuki、Ohtawa Masaki、Watanabe Nozomu、Demachi Ayumu、Ohte Satoshi、Katagiri Takenobu、Nagamitsu Tohru、Tomoda Hiroshi
    • Journal Title

      Organic Letters

      Volume: 19 Issue: 21 Pages: 5980-5983

    • DOI

      10.1021/acs.orglett.7b03003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] A novel molecular mechanism for the activation of a BMP type I receptor, ALK2, proposed from research on fibrodysplasia ossificans progressiva2020

    • Author(s)
      Katagiri T, Tsukamoto S, Kuratani M, Tsuji S, Takaishi K, Kunikata T, Nakamura K, Kawaguchi Y
    • Organizer
      Gordon Research Conference on Bones and Teeth
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 進行性骨化性線維異形成症に対する治療薬の開発研究2019

    • Author(s)
      片桐岳信
    • Organizer
      脊柱靭帯骨化症に関する調査研究 令和元年度 第2回班会議
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 進行性骨化性線維異形成症(FOP)に対する抗ALK2抗体の開発2019

    • Author(s)
      片桐岳信
    • Organizer
      精神・神経疾患研究開発費 ジストロフィン欠損モデル動物を基盤とした筋ジストロフィーの新しい治療法開発 令和元年度 研究班会議
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Characterization of an anti-ALK2 blocking antibody, DaVinci2019

    • Author(s)
      Katagiri T, Tsukamoto S, Kuratani M, Tsuji S, Takaishi K, Kunikata T, Nakamura K, Kawaguchi Y
    • Organizer
      2019 FOP Family Gathering
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Characterization of an anti-ALK2 blocking antibody, DaVinci.2019

    • Author(s)
      Katagiri T, Tsukamoto S, Kuratani M, Tsuji S, Takaishi K, Kunikata T, Nakamura K, Kawaguchi Y
    • Organizer
      2019 FOP Drug Development Forum
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 病態生理部門における骨を核とした研究活動2019

    • Author(s)
      片桐岳信
    • Organizer
      第17回RCGMフロンティアシンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 抗ALK2阻害抗体の結合と阻害活性に重要なALK2細胞外領域アミノ酸残基の同定2019

    • Author(s)
      片桐岳信、塚本翔、倉谷麻衣
    • Organizer
      第37回日本骨代謝学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identiffication of a critical amino acid residue in ALK2 for the binding and inhibition by the anti-ALK2 blocking antibody2019

    • Author(s)
      Katagiri T, Tsukamoto S, Kuratani M, Tsuji S, Takaishi K, Kunikata T, Nakamura K, Kawaguchi Y, Hasegawa J
    • Organizer
      ASBMR 2019 Annual meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wnt7b expressed by hypertrophic chondrocytes is a critical inducer of bone formation during endochondral ossification2019

    • Author(s)
      Tsukamoto S, Kuratani M, Sekine N, Okubo M, Tanaka S, Jimi E, Oda H, Katagiri T
    • Organizer
      ASBMR 2019 Annual meeting
    • Related Report
      2019 Annual Research Report
  • [Presentation] Wnt7bは内軟性国家における骨形成誘導因子である2019

    • Author(s)
      塚本翔、倉谷麻衣、関根典子、大久保美里、田中伸哉、自見英治郎、織田弘美、片桐岳信
    • Organizer
      第17回RCGMフロンティアシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] A crosstalk between Wnt and TGF-β/BMP families regulates endochondral bone formation2019

    • Author(s)
      Tsukamoto S, Kuratani M, Sekine N, Okubo M, Tanaka S, Jimi E, Oda H, Katagiri T
    • Organizer
      Gordon Research Conference on Wnt Signaling
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identiffication of a critical amino acid residue in ALK2 for the binding and inhibition by the anti-ALK2 blocking antibody2019

    • Author(s)
      Katagiri T, Tsukamoto S, Kuratani M, Tsuji S, Takaishi K, Kunikata T, Nakamura K, Kawaguchi Y, Hasegawa J
    • Organizer
      FASEB SRC on TGF-β Superfamily
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A role of dimer formation of ALK2, a BMP typeⅠ receptor in the activation of intracellular signaling2019

    • Author(s)
      Katagiri T, Tsuji S, Tsukamoto S, Kuratani M, Ohte S, Sekine N, Kumagai K, Osawa K, Takaishi K, Nakamura K, Kawaguchi Y, Hasegawa J
    • Organizer
      Gordon Research Conference on Cartilage
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 内軟骨性骨化におけるBMPとWntの新たなクロストーク2019

    • Author(s)
      塚本翔、倉谷麻衣、関根典子、大久保美里、田中伸哉、自見英治郎、織田弘美、片桐岳信
    • Organizer
      第5回日本骨免疫学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of blocking antibodies against ALK2 for fibrodysplasia ossificans progressiva.2018

    • Author(s)
      Katagiri T, Tsuji S, Tsukamoto S, Kuratani M, Ohte S, Sekine N, Kumagai K, Osawa K, Takaishi K, Nakamura K, Kawaguchi Y
    • Organizer
      Muscle 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BMP受容体ALK2に対する特異的阻害抗体の解析.2018

    • Author(s)
      片桐岳信、辻真之介、塚本翔、倉谷麻衣、大手聡、高石巨澄、中村健介、川口喜朗、長谷川淳
    • Organizer
      第4回日本骨免疫学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 異所性骨化の発症機序の解明と治療薬開発への応用.2018

    • Author(s)
      片桐岳信
    • Organizer
      第39回日本再生・医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] A novel crosstalk between the TGF-β and Wnt families in endochondral ossification.2018

    • Author(s)
      Tsukamoto, S., Kuratani, M., Sekine, N., Okubo, M., Nakachi, Y., Katagiri, T
    • Organizer
      The 16th RCGM International Symposium of Academic Frontier
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gene analysis related to Gender Dysphoria.2018

    • Author(s)
      Nakachi, Y., Tsukamoto, S., Iwanaga, Y., Katagiri, T
    • Organizer
      The 16th RCGM International Symposium of Academic Frontier
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel crosstalk between TGF-β/BMP and Wnt families through Smad4 in endochondral ossification.2018

    • Author(s)
      Tsukamoto, S., Kuratani, M., Sekine, N., Okubo, M., Nakachi, Y., Tanaka, S., Jimi, E., Oda, H., Katagiri, T.
    • Organizer
      ASBMR 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel crosstalk between TGF-β/BMP and Wnt families through Smad4 in endochondral ossification.2018

    • Author(s)
      Tsukamoto, S., Kuratani, M., Sekine, N., Okubo, M., Nakachi, Y., Tanaka, S., Jimi, E., Oda, H., Katagiri, T.
    • Organizer
      Mechanistic and Therapeutic Advances in Rare Skeletal Diseases Research Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An antibody against ALK2 extracellular domain reveals a role of dimer formation for signal activation.2018

    • Author(s)
      Katagiri, T., Tsuji, S., Tsukamoto, S., Kuratani, M., Ohte, S., Takaishi, K., Nakamura, K., Kawaguchi, Y., Hasegawa, J.
    • Organizer
      ASBMR 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel crosstalk between BMP and Wnt7b in postnatal endochondral ossification.2018

    • Author(s)
      Tsukamoto, S., Kuratani, M., Sekine, N., Okubo, M., Nakachi, Y., Tanaka, S., Jimi E., Oda, H., Katagiri, T.
    • Organizer
      12th International BMP Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression levels of BMP ligands are increased by muscle trauma.2018

    • Author(s)
      Kuratani, M., Tsukamoto, S., Sekine, N., Okubo, M., Nakachi, Y., Katagiri, T.
    • Organizer
      12th International BMP Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A role of dimer formation of ALK2, a BMP type I receptor, in the activation of intracellular signaling.2018

    • Author(s)
      Katagiri, T., Tsuji, S., Tsukamoto, S., Kuratani, M., Ohte, S., Takaishi, K., Nakamura, K., Kawaguchi, Y., Hasegawa, J.
    • Organizer
      Gordon Research Conference on Cartilage
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 筋肉が骨に変わる難病の克服に向けて2018

    • Author(s)
      片桐岳信
    • Organizer
      飯能ロータリークラブ講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] A connection between bone and muscle by BMPs.2018

    • Author(s)
      Katagiri, T.
    • Organizer
      Seminar at University of California Davis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 進行性骨化性線維異形成症(FOP)に対する革新的治療薬の創出2018

    • Author(s)
      片桐岳信
    • Organizer
      第16回RCGM国際フロンティアシンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] FOPの克服に向けて2018

    • Author(s)
      片桐岳信
    • Organizer
      第12回 国際BMPカンファレンス 市民公開講座 FOPを治す!~研究者から患者へのメッセージ~
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Bone morphogenetic proteins: critical regulators of bone formation.2018

    • Author(s)
      Katagiri, T
    • Organizer
      12th International BMP Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Gift from C2C12 myoblasts.2018

    • Author(s)
      Katagiri, T
    • Organizer
      12th International BMP Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of blocking antibodies against ALK2 for fibrodysplasia ossificans progressiva.2018

    • Author(s)
      Katagiri T, Tsuji S, Tsukamoto S, Kuratani M, Ohte S, Sekine N, Kumagai K, Osawa K, Takaishi K, Nakamura K, Kawaguchi Y
    • Organizer
      Gordon Research Conference on Bones and Teeth
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of blocking antibodies against ALK2 for fibrodysplasia ossificans progressiva.2018

    • Author(s)
      Katagiri T, Tsuji S, Tsukamoto S, Kuratani M, Ohte S, Sekine N, Kumagai K, Osawa K, Takaishi K, Nakamura K, Kawaguchi Y
    • Organizer
      Gordon Research Conference on Antibody Biology and Engineering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生理的および病的な骨形成を制御するBMP研究の最前線2017

    • Author(s)
      片桐岳信
    • Organizer
      第90回日本内分泌学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 進行性骨化性線維異形成症の病態解明に基づく治療薬開発2017

    • Author(s)
      片桐岳信
    • Organizer
      第59回歯科基礎医学会学術大会 メインシンポジウムA
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Update of an anti-ALK2 blocking antibody.2017

    • Author(s)
      Katagiri T
    • Organizer
      FOP Drug Development Forum 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] FOPの創薬に向けた取り組み2017

    • Author(s)
      片桐岳信
    • Organizer
      FOP研究班報告会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 進行性骨化性線維異形成症FOPの克服に向けた取り組み2017

    • Author(s)
      片桐岳信
    • Organizer
      第15回RCGMフロンティアシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 難病FOP研究の最先端.2017

    • Author(s)
      片桐岳信
    • Organizer
      九州歯科大学大学院セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] BMPのI型受容体ALK2に対する特異的阻害抗体の開発.2017

    • Author(s)
      片桐岳信、辻真之介、塚本翔、大手聡、熊谷桂吾、大澤賢次、高石巨澄、中村健介、川口喜朗、長谷川淳
    • Organizer
      第3回日本骨免疫学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of blocking monoclonal antibodies against ALK2, which is a type I receptor for BMPs.2017

    • Author(s)
      Katagiri T, Tsuji S, Tsukamoto S, Ohte S, Kumagai K, Osawa K, Takaishi K, Nakamura K, Kawaguchi Y, Hasegawa J
    • Organizer
      2017 FASEB Science Research Conferences on The TGF-β Superfamily
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of skeletal growth in Smad4 knockout mice.2017

    • Author(s)
      Tsukamoto S, Sekine N, Kuratani M, Kumagai K, Tanaka S, Jimi E, Oda H, Katagiri T
    • Organizer
      2017 FASEB Science Research Conferences on The TGF-β Superfamily
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 軟組織における異所性骨化を誘導するBMP受容体ALK2に対する特異的阻害抗体の開発2017

    • Author(s)
      片桐岳信、辻真之介、塚本翔、大手聡、熊谷桂吾、大澤賢次、高石巨澄
    • Organizer
      第35回日本骨代謝学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of blocking monoclonal antibodies against ALK2, which is a type I receptor for BMPs.2017

    • Author(s)
      Katagiri T, Tsuji S, Tsukamoto S, Ohte S, Kumagai K, Osawa K, Takaishi K, Nakamura K, Kawaguchi Y, Hasegawa J
    • Organizer
      2017 ASBMR Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ostnatal ablation of Smad4 enhances endochondral ossification in epiphyseal growth plate.2017

    • Author(s)
      Tsukamoto S, Sekine N, Kuratani M, Kumagai K, Tanaka S, Jimi E, Oda H, Katagiri T
    • Organizer
      2017 ASBMR Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of skeletal phenotypes in Smad4 conditional knockout mice.2017

    • Author(s)
      Tsukamoto S, Sekine N, Kuratani M, Kumagai K, Jimi E, Katagiri T
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of the TGF-β family ligands that are increased in regenerating skeletal muscle and induce BMP signaling via a mutant ALK2 associated with fibrodysplasia ossificans progressiva.2017

    • Author(s)
      Kuratani M, Tsukamoto S, Katagiri T
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 転写共役因子Smad4は軟骨細胞分化を介して骨形成を制御する.2017

    • Author(s)
      塚本翔、関根典子、倉谷麻衣、熊谷桂吾、大久保美里、片桐岳信
    • Organizer
      第15回RCGMフロンティアシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] BMP受容体ALK2が誘導する異所性骨化モデルの構築2017

    • Author(s)
      倉谷麻衣、塚本翔、関根典子、片桐岳信
    • Organizer
      第15回RCGMフロンティアシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Remarks] 埼玉医科大学FOP診療・研究プロジェクト

    • URL

      http://www.saitama-med.ac.jp/medlinks/saitama_univ_fop/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 埼玉医科大学医学部基礎医学

    • URL

      http://www.saitama-med.ac.jp/uinfo/biomedsci/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 埼玉医科大学ゲノム医学研究センター病態生理部門

    • URL

      http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 埼玉医科大学ゲノム医学研究センター 病態生理部門

    • URL

      http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨形成促進作用を有する物質のスクリーニング方法、並びにGpr124及びReckの少なくともいずれかを発現する細胞を含む細胞集団の調製方法2018

    • Inventor(s)
      片桐岳信、塚本 翔
    • Industrial Property Rights Holder
      学校法人埼玉医科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-113327
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi