Epigenomic cohort study in the ART-derived children
| Project/Area Number |
17H04335
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岡江 寛明 東北大学, 医学系研究科, 准教授 (10582695)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2017: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 生殖補助医療（ART） / ゲノムインプリンティング / 胎盤 / DNAメチル化 / microRNA / 先天性インプリント異常症 / 生殖医学 / 生殖補助医療 / miRNA |
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| Outline of Final Research Achievements |
Assisted reproductive technology (ART) has become increasingly common due to late marriage and improvement of medical technology. However, the majority of recent studies published have suggested an increased incidence of normally very rare imprinting disorders in babies conceived after ART. The relationship between ART and aberrant genomic imprinting is still unclear. However, the major epigenetic events take place in the process of ART. The isolation and culture of early embryos may prevent the proper establishment and maintenance of genomic imprinting and cause imprinting disorders. 1) The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer (BT) 2) Genome-wide microRNA expression profiling in placentae from frozen-thawed BT 3) Association of four congenital imprinting disorders and ART. These results help to clarity the necessity for new standards for reform in ART in order to increase safety and produce healthy babies.
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| Academic Significance and Societal Importance of the Research Achievements |
生殖細胞および初期胚において、DNAメチル化などのエピジェネティクスが非常にダイナミックに変動する。DNAメチル化は、受精の際安定に維持されるGIを制御するため、配偶子や初期胚を扱うART操作の安全性とリスク評価には最適な指標である。本研究では、ART出生児の身体的特徴とエピゲノム解析を組み合わせ、リスクの一端を示した。また、先天性GI異常症におけるメチル化パターン分析は、疾患の病因、病態の解明にとどまらず、今後のART操作のリスク要因の発見に繋がり、安全性の高い標準化したART治療へ貢献できると予想される。
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Associations of erythrocyte fatty acid compositions with FADS1 gene polymorphism in Japanese mothers and infants.2020
Author(s)
Nita R, Kawabata T, Kagawa Y, Nakayama K, Yanagisawa Y, Iwamoto S, Kimura F, Miyazawa T, Tatsuta N, Arima T, Yaegashi N, Nakai K.
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Journal Title
Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume: 152
Pages: 102031-102031
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationships between docosahexaenoic acid compositions of maternal and umbilical cord erythrocytes in pregnant Japanese women2019
Author(s)
K. Yamada, T. Kawabata, Y. Kagawa, F. Kimura, T. Miyazawa, N. Tatsuta, S. Saito, T. Arima, N. Yaegashi, K. Nakai.
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Journal Title
Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume: -
Pages: 1-5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Blood pressure changes during twin pregnancies: the Japan Environment and Children's Study.2019
Author(s)
Iwama N, Metoki H, Nishigori H, Mizuno S, Takahashi F, Tanaka K, Watanabe Z, Saito M, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Sugiyama T, Fujiwara I, Kuriyama S, Arima T, Nakai K, Yaegashi N, Japan Environment Children;s Study Group.
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Journal Title
J Hypertens.
Volume: 37(1):206-215.
Pages: 206-215
Related Report
Peer Reviewed / Open Access
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[Journal Article] Preconception folic acid supplementation use and the occurrence of neural tube defects in Japan, A nationwide birth cohort study of the Japan Environment and Children's Study.2019
Author(s)
75.Nishigori H, Obara T, Nishigori T, Ishikuro M, Sakurai K, Hoshiai T, Saito M, Fujiwara I, Arima T, Nakai K, Kuriyama S, Mano N, Metoki H, Yaegashi N; Japan Environment Children's Study Group.
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Journal Title
Congenit Anom (Kyoto)
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lactate Dehydrogenase C Is Required for the protein Expression of a Sperm-specific Isoform of Lactate Dehydrogenase A.2019
Author(s)
Dodo M, Kitamura H, Shima H, Wati S, Ota N, Chiba H, Okae H, Arima T, Igarashi K, Koseki H, Sekine H, Motohashi H.
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Journal Title
The Journal of Biochemistry
Volume: 印刷中
NAID
Related Report
Open Access
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[Journal Article] The risk of secondary sex ratio imbalance and increased monozygotic twinning 1 after blastocyst transfer: data from The Japan Environment and Children’s Study.2019
Author(s)
Hattori H, Kitamura A, Takahashi F, Kobayashi N, Sato A, Miyauchi N, Nishigori H, Mizuno S, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Fujiwara I, Kuriyama S, Metoki H, Yaegashi N, Nakai K, Arima T, Japan Environment Children;s Study Group.
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Journal Title
Reproductive Biology and Endocrinology
Volume: 17
Pages: 27-27
Related Report
Open Access
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[Journal Article] Association of four imprinting disorders and ART.2019
Author(s)
Hattori H, Hiura H, Kitamura A, Miyauchi N, Kobayashi N, Takahashi S, Okae H, Kyono K, Kagami M, Ogata T, Arima T.
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Journal Title
Clinical Epigenetics
Volume: 11
Pages: 21-21
Related Report
Peer Reviewed / Open Access
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[Journal Article] Update on the prevalence and determinants of folic acid use in Japan evaluated with 91,538 pregnant women: the Japan environment and Children's Study.2018
Author(s)
Ishikawa T, Obara T, Nishigori H, Nishigori T, Metoki H, Ishikuro M, Tatsuta N, Mizuno S, Sakurai K, Nishijima I, Murai Y, Fujiwara I, Arima T, Nakai K, Yaegashi N, Kuriyama S, Mano N, JECS Group.
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Journal Title
J Matern Fetal Neonatal Med.
Volume: 27
Pages: 221-221
Related Report
Peer Reviewed / Open Access
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[Journal Article] Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study.2018
Author(s)
Watanabe Z, Nishigori H, Tanoue K, Tanaka K, Iwama N, Satoh M, Murakami T, Nishigori T, Mizuno S, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Saito M, Tachibana M, Fujiwara I, Arima T, Takeda T, Kuriyama S, Nakai K, Yaegashi N, Metoki H, Japan Environment Children's Study Group.
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Journal Title
J Affect Disord.
Volume: 5
Pages: 475-483
Related Report
Peer Reviewed / Open Access
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[Book] 実験医学2018
Author(s)
岡江寛明、有馬隆博
Total Pages
1430
Publisher
羊土社
Related Report
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