Identification of the pathogenesis from the origin to uterine carcinosarcoma based on evolutional theory

• Project/Area Number: 17H04336
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Niigata University
• Principal Investigator: Enomoto Takayuki 新潟大学, 医歯学系, 教授 (90283754)
• Co-Investigator(Kenkyū-buntansha): 井ノ上 逸朗 国立遺伝学研究所, ゲノム・進化研究系, 教授 (00192500) ; 吉原 弘祐 新潟大学, 医歯学系, 研究准教授 (40547535) ; 安達 聡介 新潟大学, 医歯学総合病院, 助教 (50613147) ; 石黒 竜也 新潟大学, 医歯学総合病院, 助教 (80625690)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
• Keywords: 子宮癌肉腫 / 発生起源 / オミックスデータ / 遺伝子変異 / 融合遺伝子 / 癌幹細胞

Outline of Final Research Achievements

The origin of carcinosarcoma is cancer stem cell derived from endometrium. We focused on spheroid cells which had a potential of cancer stem cell and examined biological characteristics of spheroid cells derived from uterine endometrial cancera. ALDH activity was associated with cancer stem cell characteristics in the spheroid cells. High ALDH activity was also related to paclitaxel resistance and combination therapy of paclitaxel and ALDH inhibitor demonstratred the synergistic effect for ALDH-high spheroid cells. Our cultivation method of spheroid cells may be useful for screening of clinical cases with high ALDH activity and respond to anti-ALDH therapy in combination with paclitaxel.

Academic Significance and Societal Importance of the Research Achievements

癌幹細胞を標的とする難治性癌の新規臨床治療戦略を開発するには三次元スフェロイド培養法が重要な方法となるが、癌幹細胞の特徴を持つ子宮内膜由来のスフェロイドがin vitroで安定して増殖できることを初めて実証した。また子宮内膜由来のスフェロイドの機能解析により、ALDH活性またはALDH1A1発現が癌幹細胞の増殖を促進することが示された。本研究により、タキサン化合物とALDH阻害剤の併用が子宮内膜癌・癌肉腫に対する新たな治療の選択肢となる可能性が示されたことは、治療が限られている子宮内膜癌・癌肉腫にとって大きな意義がある。

Research Products

• [Journal Article] Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis (2020)
  • Author(s): Suda Kazuaki、Cruz Diaz Luis Antonio、Yoshihara Kosuke、Nakaoka Hirofumi、Yachida Nozomi、Motoyama Teiichi、Inoue Ituro、Enomoto Takayuki
  • Journal Title: Cancer Science Volume: - Issue: 8 Pages: 3000-3009
  • DOI: 10.1111/cas.14507
  • Peer Reviewed / Open Access
• [Journal Article] Proposal of a Two-Tier System in Grouping Adenocarcinoma of the Uterine Cervix (2020)
  • Author(s): Machida Hiroko、Matsuo Koji、Matsuzaki Shinya、Yamagami Wataru、Ebina Yasuhiko、Kobayashi Yoichi、Tabata Tsutomu、Kaneuchi Masanori、Nagase Satoru、Enomoto Takayuki、Mikami Mikio
  • Journal Title: Cancers Volume: 12 Issue: 5 Pages: 1251-1251
  • DOI: 10.3390/cancers12051251
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary (2020)
  • Author(s): Tamura Ryo、Yoshihara Kosuke、Nakaoka Hirofumi、Yachida Nozomi、Yamaguchi Manako、Suda Kazuaki、Ishiguro Tatsuya、Nishino Koji、Ichikawa Hiroshi、Homma Keiichi、Kikuchi Akira、Ueda Yutaka、Takei Yuji、Fujiwara Hiroyuki、Motoyama Teiichi、Okuda Shujiro、Wakai Toshifumi、Inoue Ituro、Enomoto Takayuki
  • Journal Title: Oncogene Volume: 39 Issue: 17 Pages: 3541-3554
  • DOI: 10.1038/s41388-020-1237-0
  • Peer Reviewed / Open Access
• [Journal Article] Germline and somatic mutations of homologous recombination-associated genes in Japanese ovarian cancer patients (2019)
  • Author(s): Sugino Kentaro、Tamura Ryo、Nakaoka Hirofumi、Yachida Nozomi、Yamaguchi Manako、Mori Yutaro、Yamawaki Kaoru、Suda Kazuaki、Ishiguro Tatsuya、Adachi Sosuke、Isobe Masanori、Yamaguchi Masayuki、Kashima Katsunori、Motoyama Teiichi、Inoue Ituro、Yoshihara Kosuke、Enomoto Takayuki
  • Journal Title: Scientific Reports Volume: 9 Issue: 1
  • DOI: 10.1038/s41598-019-54116-y
  • Peer Reviewed / Open Access
• [Journal Article] ALDH-dependent glycolytic activation mediates stemness and Paclitaxel resistance in patient-derived spheroid models of uterine endometrial cancer (2019)
  • Author(s): Mori Y, Yamawaki K, Ishiguro T, Yoshihara K, Ueda H, Sato A, Ohata H, Yoshida Y, Minamino T, Okamoto K, Enomoto T
  • Journal Title: Stem Cell Reports Volume: 13 Issue: 4 Pages: 730-730
  • DOI: 10.1016/j.stemcr.2019.08.015
  • Peer Reviewed / Open Access
• [Journal Article] Concurrent isolated retroperitoneal HGSC and STIC defined by somatic mutation analysis: a case report (2019)
  • Author(s): Suda Kazuaki、Nakaoka Hirofumi、Hata Chihiro、Yahata Natsumi、Isobe Masanori、Kameyama Hitoshi、Wakai Toshifumi、Motoyama Teiichi、Inoue Ituro、Yoshihara Kosuke、Enomoto Takayuki
  • Journal Title: Diagnostic Pathology Volume: 14 Issue: 1 Pages: 17-17
  • DOI: 10.1186/s13000-019-0795-3
  • Peer Reviewed / Open Access
• [Journal Article] Association of statins, aspirin, and venous thromboembolism in women with endometrial cancer (2019)
  • Author(s): Matsuo Koji、Hom Marianne S.、Yabuno Akira、Shida Masako、Kakuda Mamoru、Adachi Sosuke、Mandelbaum Rachel S.、Ueda Yutaka、Hasegawa Kosei、Enomoto Takayuki、Mikami Mikio、Roman Lynda D.
  • Journal Title: Gynecologic Oncology Volume: 152 Issue: 3 Pages: 605-611
  • DOI: 10.1016/j.ygyno.2018.12.020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel MXD4-NUTM1 fusion transcript identified in primary ovarian undifferentiated small round cell sarcoma (2018)
  • Author(s): Tamura Ryo、Nakaoka Hirofumi、Yoshihara Kosuke、Mori Yutaro、Yachida Nozomi、Nishikawa Nobumichi、Motoyama Teiichi、Okuda Shujiro、Inoue Ituro、Enomoto Takayuki
  • Journal Title: Genes, Chromosomes and Cancer Volume: 57 Issue: 11 Pages: 557-563
  • DOI: 10.1002/gcc.22668
  • Peer Reviewed / Open Access
• [Journal Article] Japan Society of Gynecologic Oncology guidelines 2017 for the treatment of uterine cervical cancer (2018)
  • Author(s): Ebina Yasuhiko、Mikami Mikio、Nagase Satoru、Tabata Tsutomu、Kaneuchi Masanori、Tashiro Hironori、Mandai Masaki、Enomoto Takayuki、Kobayashi Yoichi、Katabuchi Hidetaka、Yaegashi Nobuo、Udagawa Yasuhiro、Aoki Daisuke
  • Journal Title: International Journal of Clinical Oncology Volume: 24 Issue: 1 Pages: 1-19
  • DOI: 10.1007/s10147-018-1351-y
  • Peer Reviewed
• [Journal Article] Trachelectomy for stage IB1 cervical cancer with tumor size >2 cm: trends and characteristics in the United States (2018)
  • Author(s): Matsuo Koji、Machida Hiroko、Mandelbaum Rachel S.、Mikami Mikio、Enomoto Takayuki、Roman Lynda D.、Wright Jason D.
  • Journal Title: Journal of Gynecologic Oncology Volume: 29 Issue: 6
  • DOI: 10.3802/jgo.2018.29.e85
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characteristics and outcomes of reproductive-aged women with early-stage cervical cancer: trachelectomy vs hysterectomy (2018)
  • Author(s): Machida Hiroko、Mandelbaum Rachel S.、Mikami Mikio、Enomoto Takayuki、Sonoda Yukio、Grubbs Brendan H.、Paulson Richard J.、Roman Lynda D.、Wright Jason D.、Matsuo Koji
  • Journal Title: American Journal of Obstetrics and Gynecology Volume: 219 Issue: 5 Pages: 461.e1-461.e18
  • DOI: 10.1016/j.ajog.2018.08.020
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium (2018)
  • Author(s): Suda Kazuaki、Nakaoka Hirofumi、Yoshihara Kosuke、Ishiguro Tatsuya、Tamura Ryo、Mori Yutaro、Yamawaki Kaoru、Adachi Sosuke、Takahashi Tomoko、Kase Hiroaki、Tanaka Kenichi、Yamamoto Tadashi、Motoyama Teiichi、Inoue Ituro、Enomoto Takayuki
  • Journal Title: Cell Reports Volume: 24 Issue: 7 Pages: 1777-1789
  • DOI: 10.1016/j.celrep.2018.07.037
  • Peer Reviewed / Open Access
• [Journal Article] Proposal for a Risk-Based Categorization of Uterine Carcinosarcoma (2018)
  • Author(s): Matsuo Koji、Takazawa Yutaka、Ross Malcolm S.、Elishaev Esther、Yunokawa Mayu、Sheridan Todd B.、Bush Stephen H.、Klobocista Merieme M.、Blake Erin A.、Takano Tadao、Baba Tsukasa、Satoh Shinya、Shida Masako、Ikeda Yuji、et al.
  • Journal Title: Annals of Surgical Oncology Volume: 25 Issue: 12 Pages: 3676-3684
  • DOI: 10.1245/s10434-018-6695-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma (2018)
  • Author(s): Matsuo Koji、Takazawa Yutaka、Ross Malcolm S.、Elishaev Esther、Yunokawa Mayu、Sheridan Todd B.、Bush Stephen H.、Klobocista Merieme M.、Blake Erin A.、Takano Tadao、Baba Tsukasa、Satoh Shinya、Shida Masako、Ikeda Yuji、et al.
  • Journal Title: Annals of Surgical Oncology Volume: 25 Issue: 9 Pages: 2756-2766
  • DOI: 10.1245/s10434-018-6547-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Postoperative chemotherapy for node-positive cervical cancer: Results of a multicenter phase II trial (JGOG1067) (2018)
  • Author(s): Matoda Maki、Takeshima Nobuhiro、Michimae Hirofumi、Iwata Takashi、Yokota Harushige、Torii Yutaka、Yamamoto Yorito、Takehara Kazuhiro、Nishio Shin、Takano Hirokuni、Mizuno Mika、Takahashi Yoshiyuki、Takei Yuji、Hasegawa Tetsuya、Mikami Mikio、Enomoto Takayuki、Aoki Daisuke、Sugiyama Toru
  • Journal Title: Gynecologic Oncology Volume: 149 Issue: 3 Pages: 513-519
  • DOI: 10.1016/j.ygyno.2018.04.009
  • Peer Reviewed
• [Journal Article] Significance of abnormal peritoneal cytology on survival of women with stage I-II endometrioid endometrial cancer. (2018)
  • Author(s): Matsuo K, Yabuno A, Hom MS, Shida M, Kakuda M, Adachi S, Mandelbaum RS, Ueda Y, Hasegawa K, Enomoto T, Mikami M, Roman LD.
  • Journal Title: Gynecol Oncol Volume: 印刷中 Issue: 2 Pages: 301-309
  • DOI: 10.1016/j.ygyno.2018.02.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions (2018)
  • Author(s): Tamura R, Yoshihara K, Saito T, Ishimura R, Martinez-Ledesma JE, Xin H, Ishiguro T, Mori Y, Yamawaki K, Suda K, Sato S, Itamochi H, Motoyama T, Aoki Y, Okuda S, Casingal CR, Nakaoka H, Inoue I, Verhaak RGW, Komatsu M, Enomoto T.
  • Journal Title: Oncogenesis Volume: 7 Issue: 1 Pages: 4-4
  • DOI: 10.1038/s41389-017-0018-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microdissection testicular sperm extraction in five Japanese patients with non-mosaic Klinefelter's syndrome (2018)
  • Author(s): Chihara Makoto、Ogi Kanna、Ishiguro Tatsuya、Yoshida Kunihiko、Godo Chikako、Takakuwa Koichi、Enomoto Takayuki
  • Journal Title: Reproductive Medicine and Biology Volume: 17 Issue: 2 Pages: 209-216
  • DOI: 10.1002/rmb2.12092
  • Peer Reviewed
• [Journal Article] Dynamic changes in Japan’s prevalence of abnormal findings in cervical cervical cytology depending on birth year (2018)
  • Author(s): Ueda Yutaka、Yagi Asami、Nakayama Tomio、Hirai Kei、Ikeda Sayaka、Sekine Masayuki、Miyagi Etsuko、Enomoto Takayuki
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 5612-5612
  • DOI: 10.1038/s41598-018-23947-6
  • Peer Reviewed / Open Access
• [Journal Article] Malignancy during pregnancy in Japan: an exceptional opportunity for early diagnosis. (2018)
  • Author(s): Sekine M, Kobayashi Y, Tabata T, Sudo T, Nishimura R, Matsuo K, Grubbs BH, Enomoto T, Ikeda T.
  • Journal Title: BMC Pregnancy Childbirth. Volume: 18(1) Issue: 1 Pages: 50-50
  • DOI: 10.1186/s12884-018-1678-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake (2018)
  • Author(s): Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, Morimoto A, Matsuzaki S, Yokoyama T, Takahashi T, Fujimoto M, Takemori H, Ueda Y, Yoshino K, Morii E, Kimura T, Naka T
  • Journal Title: Cancer Res Volume: 78 Issue: 2 Pages: 516-27
  • DOI: 10.1158/0008-5472.can-17-0910
  • Peer Reviewed / Open Access
• [Journal Article] Genetic and clinical characteristics in Japanese hereditary breast and ovarian cancer: first report after establishment of HBOC registration system in Japan (2017)
  • Author(s): Arai Masami、Yokoyama Shiro、Watanabe Chie、Yoshida Reiko、Kita Mizuho、Okawa Megumi、Sakurai Akihiro、Sekine Masayuki、Yotsumoto Junko、Nomura Hiroyuki、Akama Yoshinori、Inuzuka Mayuko、Nomizu Tadashi、Enomoto Takayuki、Nakamura Seigo
  • Journal Title: Journal of Human Genetics Volume: 63 Issue: 4 Pages: 447-457
  • DOI: 10.1038/s10038-017-0355-1
  • Peer Reviewed
• [Journal Article] Recurrent ovarian undifferentiated carcinoma resembling hepatoid morphology treated with pegylated liposomal doxorubicin and bevacizumab. (2017)
  • Author(s): Ishiguro T, Kashima K, Yachida N, Motoyama T, Enomoto T.
  • Journal Title: J Obstet Gynaecol Res. Volume: 43 Issue: 5 Pages: 957-961
  • DOI: 10.1111/jog.13298
  • Peer Reviewed
• [Journal Article] Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer. (2017)
  • Author(s): Yamawaki K, Ishiguro T, Mori Y, Yoshihara K, Suda K, Tamura R, Yamaguchi M, Sekine M, Kashima K, Higuchi M, Fujii M, Okamoto K, Enomoto T
  • Journal Title: Cancer Sci. Volume: 108 Issue: 4 Pages: 632-640
  • DOI: 10.1111/cas.13196
  • Peer Reviewed / Open Access
• [Journal Article] Biochemical analysis of intraplacental choriocarcinoma and fetomaternal transfusion. (2017)
  • Author(s): Ishiguro T, Suda K, Enomoto T.
  • Journal Title: J Obstet Gynaecol Res. Volume: 43 Issue: 3 Pages: 587-591
  • DOI: 10.1111/jog.13232
  • Peer Reviewed
• [Journal Article] Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications. (2017)
  • Author(s): Ishiguro T, Ohata H, Sato A, Yamawaki K, Enomoto T, Okamoto K.
  • Journal Title: Cancer Sci. Volume: 108 Issue: 3 Pages: 283-289
  • DOI: 10.1111/cas.13155
  • Peer Reviewed / Open Access
• [Presentation] Homologous recombination deficiency (HRD) in Japanese patients with ovarian cancer (2019)
  • Author(s): Kosuke Yoshihara
  • Organizer: 2019 the Japanese Society of Medical Oncology Annual Meeting
  • Invited
• [Presentation] Cancer-associated gene mutations in ovarian endometriosis and normal uterine endometrium (2019)
  • Author(s): Kosuke Yoshihara
  • Organizer: The 78th Annual Meeting of the Japanese Cancer Association
  • Invited
• [Presentation] 子宮頸癌 (2018)
  • Author(s): 榎本隆之
  • Organizer: 第8回生長会 産婦人科レビューコース
• [Presentation] 婦人科腫瘍におけるPrecision Medicineの現況と展望 (2018)
  • Author(s): 榎本隆之
  • Organizer: 第70回日本産科婦人科学会学術講演会
• [Presentation] Effectiveness of national HPV vaccination program for Japanese young women (2018)
  • Author(s): 榎本隆之
  • Organizer: 第5回国際婦人科腫瘍学会
  • Int'l Joint Research / Invited
• [Presentation] HPVワクチンの有効性についてー本邦の報告ー (2018)
  • Author(s): 榎本隆之
  • Organizer: 日本医師会・日本医学会合同公開フォーラム
• [Presentation] 婦人科がんについての最近の話題～がん薬物療法を含めて～ (2018)
  • Author(s): 榎本隆之
  • Organizer: 中越産婦人科医会
• [Presentation] 遺伝子発現プロファイルに基づいた卵巣癌の予後予測モデルの構築 (2018)
  • Author(s): 吉原弘祐
  • Organizer: 第6回婦人科バイオマーカー研究会
• [Presentation] Integrated Analysis of Genomic and Transcriptomic Data in Ovarian Clear Cell Carcinoma (2018)
  • Author(s): 吉原弘祐
  • Organizer: 日本産科婦人科学会 第70回学術講演会 日韓台ジョイントカンファレンス
• [Presentation] 卵巣癌における相同組換え修復異常 (2018)
  • Author(s): 吉原弘祐
  • Organizer: 第135回関東連合産科婦人科学会学術集会
• [Presentation] 婦人科癌ゲノミクスの現状と課題 (2018)
  • Author(s): 吉原弘祐
  • Organizer: JSAWI 2018
• [Presentation] Somatic mutations on cancer associated genes in endometriosis and normal uterine endometrium (2018)
  • Author(s): 吉原弘祐
  • Organizer: 第60回 日本婦人科腫瘍学会学術講演会
• [Presentation] 腹腔鏡下子宮全摘術後、尿管損傷が判明した症例 (2018)
  • Author(s): 安達聡介
  • Organizer: 第58回 日本産科婦人科内視鏡学会学術講演会
• [Presentation] 機能性単角子宮を伴う先天性膣閉鎖に対する腹腔鏡下頸管形成造膣術を施行した１例 (2018)
  • Author(s): 石黒竜也
  • Organizer: 第27回 新潟内視鏡外科研究会
• [Presentation] ミューラー管由来組織の遺残を認めた完全型アンドロゲン不応症 (2018)
  • Author(s): 石黒竜也
  • Organizer: 第58回 日本産科婦人科内視鏡学会学術講演会
• [Presentation] 帝王切開後の腹壁創部内膜症 (2018)
  • Author(s): 石黒竜也
  • Organizer: 第180回 新潟産科婦人科集談会
• [Presentation] The significance of activated Pl3K/AKT pathway in FGFR3-TACC3 fusion positive cervical cancer (2017)
  • Author(s): Ryo Tamura, Kosuke Yoshihara, Tetsuya Saito, Ryosuke Ishimura, Emmanuel Martinez-Ledesma, Yutaro Mori, Kaoru Yamawaki, Kazuaki Suda, Tetsuya Ishiguro, Youichi Aoki, Seiya Sato, Hiroaki Itamochi, Masaaki Komatsu, Roeland Verhaak, Takayuki Enomoto
  • Organizer: AACR annual meeting 2017
  • Int'l Joint Research
• [Presentation] 遺伝性乳癌・卵巣癌症候群（HBOC) ー 婦人科腫瘍専門医の立場から (2017)
  • Author(s): 榎本隆之
  • Organizer: 第58回日本臨床細胞学会総会（春期大会）
• [Presentation] 卵巣癌術前化学療法における腹水細胞診の有用性とピットフォール 進行卵巣癌に対する腹腔鏡生検の意義 腹水細胞診による腫瘍組織型推定は可能か (2017)
  • Author(s): 西野 幸治, 安達 聡介, 榎本 隆之, 梅津 哉, 本山 悌一
  • Organizer: 第58回日本臨床細胞学会総会（春期大会）
• [Presentation] Identification of therapeutially targetable FGFR-fusion genes in cervical cancer through RNA sequencing (2017)
  • Author(s): Ryo Tamura, Kosuke Yoshihara, Yutaro Mori, Kaoru Yamawaki, Kazuaki Suda, Tatsuya Ishiguro, Yoichi Aoki, Seiya Sato, Hiroaki Itamochi, Takayuki Enomoto
  • Organizer: 第69回日本産科婦人科学会学術講演会
• [Presentation] The efficacy and safety of radical trachelectomy for early stage cervival cancer during pregnancy (2017)
  • Author(s): Kosuke Yoshihara, Nobumichi Nishikawa, Makoto Chihara, Tatsuya Ishiguro, Sosuke Adachi, Masanori Isobe, Kazufumi Haino, Koji Nishino, Masayuki Yamaguchi, Masayuki Sekine, Katsunori Kashima, Takayuki Enomoto
  • Organizer: 第69回日本産科婦人科学会学術講演会
• [Presentation] 癌性腹膜炎が疑われた結核性腹膜炎の2症例 (2017)
  • Author(s): 安達 聡介, 上田 遥香, 工藤 梨沙, 茅原 誠, 石黒 竜也, 郷戸 千賀子, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之
  • Organizer: 第59回日本婦人科腫瘍学会学術講演会
• [Presentation] 胎盤内絨毛癌の管理 (2017)
  • Author(s): 石黒 竜也, 須田 一暁, 榎本 隆之
  • Organizer: 第59回日本婦人科腫瘍学会学術講演会
• [Presentation] 卵巣癌に対するベバシズマブ投与後の手術は安全に施行可能か? (2017)
  • Author(s): 西野 幸治, 上田 遥香, 茅原 誠, 石黒 竜也, 安達 聡介, 郷戸 千賀子, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西川 伸道, 関根 正幸, 榎本 隆之
  • Organizer: 第59回日本婦人科腫瘍学会学術講演会
• [Presentation] 進行卵巣癌に対する腹腔鏡生検の意義 (2017)
  • Author(s): 谷地田 希, 西野 幸治, 安達 聡介, 上田 遥香, 工藤 梨沙, 茅原 誠, 石黒 竜也, 郷戸 千賀子, 吉原 弘祐, 小林 暁子, 西川 伸道, 関根 正幸, 榎本 隆之
  • Organizer: 第59回日本婦人科腫瘍学会学術講演会
• [Presentation] 腹腔鏡下付属器手術後に境界悪性あるいは悪性卵巣腫瘍と診断された9例の検討 (2017)
  • Author(s): 小林 暁子, 茅原 誠, 石黒 竜也, 安達 聡介, 郷戸 千賀子, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之
  • Organizer: 第59回日本婦人科腫瘍学会学術講演会
• [Presentation] 高ALDH活性を有する子宮体癌幹細胞の特性 (2017)
  • Author(s): 森 裕太郎, 山脇 芳, 石黒 竜也, 吉原 弘祐, 榎本 隆之
  • Organizer: 第76回日本癌学会
• [Presentation] 子宮頸がんの動向 大阪府がん登録データを用いた子宮頸がんの疫学的解析 (2017)
  • Author(s): 八木 麻未, 上田 豊, 中江 瑠璃子, 角張 玲沙, 松崎 慎哉, 吉野 潔, 榎本 隆之, 伊藤 ゆり, 中山 富雄, 木村 正
  • Organizer: 第76回日本癌学会
• [Presentation] 卵巣明細胞癌における新規治療標的融合遺伝子の同定 (2017)
  • Author(s): 吉原 弘祐, 森 裕太郎, 山脇 芳, 石黒 竜也, 榎本 隆之
  • Organizer: 第76回日本癌学会
• [Presentation] SOX2は子宮体がんの細胞増殖と細胞周期制御において重要である (2017)
  • Author(s): 山脇 芳, 石黒 竜也, 森 裕太郎, 吉原 弘祐, 樋口 雅也, 藤井 雅寛, 岡本 康司, 榎本 隆之
  • Organizer: 第76回日本癌学会
• [Presentation] これからの卵巣癌の治療・予防とBRCA検査 (2017)
  • Author(s): 榎本隆之
  • Organizer: 第55回日本癌治療学会学術集会