| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
In the current study, we cannot find any correlated biological background between senescence-associated secretory phenotype (SASP), and cancerization and metastatic potential in both nasopharyngeal carcinoma (NPC) and oropharyngeal carcinoma (OPC). In both carcinomas, especially in NPC, mitochondrial DNA mutations were strongly correlated with metastatic potential of NPCs. We found many mitochondrial DNA mutations were due to the effect ofcytidine deaminases (CDAs) in NPC. On the other hands, the mutations were caused both by CDAs and reactive oxigen species in OPCs.
For the above-mentioned result, the existence of the phenomenon that metastasis was promoted by the mutatiions of the mitochondrial DNA was suggested. And an elucidation of the mechanisms to relate metastasis to mitochondrial DNA mutations is needed in the future study.
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