Molecular analyses of the mechanisms of severe pneumococcal pneumonia and search for control method using neutrophil immunity

• Project/Area Number: 17H04367
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Niigata University
• Principal Investigator: Terao Yutaka 新潟大学, 医歯学系, 教授 (50397717)
• Co-Investigator(Kenkyū-buntansha): 土門 久哲 新潟大学, 医歯学系, 准教授 (00594350) ; 前川 知樹 新潟大学, 医歯学系, 研究教授 (50625168)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
• Keywords: 好中球 / 肺炎球菌 / 肺炎 / 口腔細菌学 / 誤嚥性肺炎

Outline of Final Research Achievements

It has long been known that pneumococci perform autolysis. In addition, recent pathological diagnosis has revealed that a large amount of neutrophils infiltrate human pneumococcal infection sites. Furthermore, it has been reported that the infectious disease specialists in Japan and overseas can reduce the severity of pneumonia by administering an inhibitor of neutrophil endogenous protease. However, there was no research paper that integrated and elucidated them. Therefore, we carried out the mass spectrometric analysis on the molecular mechanism by which pneumonia becomes severe from two directions: the pneumococcal side and the human neutrophil side. Then, we integrated the elucidation data of the pneumococcal side and the human side, and identified a group of molecular candidates involved in the severity of pneumonia

Academic Significance and Societal Importance of the Research Achievements

誤嚥性肺炎を含めた肺炎は，耐性菌の出現と高齢社会を迎え増加・重症化している．2016年以降，日本政府および国連が，具体名を挙げて肺炎を人類の最脅威のひとつに定義している．WHOならびに国連の最新試算では，抗菌薬以外の対策を考案できなければ，2050年以降は毎年1000万人の死者が出ると予測されている．本研究の結果，肺炎球菌だけが好中球を敢えて周囲に集積させて好中球を傷害し，同細胞の内容物を利用して感染拡大を行うユニークな知見を掴んだ．今後は本研究成果に加え，好中球を利用する肺炎球菌の病原機構を詳細解析し，その制御法へと繋げることができる．

Research Products

• [Journal Article] Sulfated vizantin inhibits biofilm maturation by Streptococcus mutans. (2020)
  • Author(s): Oda M, Kurosawa M, Yamamoto H, Domon H, Takenaka S, Osumi T, Maekawa T, Yamasaki N, Terao Y
  • Journal Title: Microbiol. Immunol. Volume: in press
  • Peer Reviewed
• [Journal Article] Sulfated vizantin inhibits biofilm maturation by Streptococcus mutans. (2020)
  • Author(s): Oda M, Kurosawa M, Yamamoto H, Domon H, Takenaka S, Osumi T, Maekawa T, Yamasaki N, Terao Y
  • Journal Title: Microbiol Immunol Volume: in press
  • Peer Reviewed
• [Journal Article] Innate immune responses in serum and cerebrospinal fluid from neonates and infants infected with parechovirus-A3 or enteroviruses. (2020)
  • Author(s): Habuka R, Aizawa Y, Izumita R, Domon H, Terao Y, Takihara H, Okuda S, Saitoh A
  • Journal Title: J Infect Dis Volume: in press
  • Peer Reviewed
• [Journal Article] Effects of sub-minimum inhibitory concentration of chlorhexidine gluconate on development of in vitro multi-species biofilms. Biofouling. (2020)
  • Author(s): Suzuki Y, Ohsumi T, Isono T, Nagata R, Hasegawa T, Takenaka S, Terao Y, Noiri Y
  • Journal Title: Biofouling Volume: in press
  • Peer Reviewed
• [Journal Article] Animal model of periodontitis ― Analysis of experimental ligature-induced periodontitis model in mice ―. (2020)
  • Author(s): Tamura H, Maekawa T, Hiyoshi T, Terao Y:
  • Journal Title: Methods Mol Biol Volume: in press
  • Peer Reviewed
• [Journal Article] Protective effect of hinokitiol against periodontal bone loss in ligature induced experimental periodontitis in mice. (2020)
  • Author(s): Hiyoshi T, Domon H, Maekawa T, Yonezawa D, Kunitomo E, Tabeta K, Terao Y
  • Journal Title: Arch Oral Biol Volume: 112(4) Pages: 104679-104679
  • Peer Reviewed
• [Journal Article] Effect of a novel glass ionomer cement containing flour-zinc-silicate fillers on biofilm formation and dentin ion incorporation. (2020)
  • Author(s): Hasegawa T, Takenaka S, Ohsumi T, Ida T, Ohshima H, Terao Y, Traithawit N, Maeda T, Noiri Y
  • Journal Title: Clin Oral Investig Volume: 24(2) Pages: 963-970
  • Peer Reviewed
• [Journal Article] Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria predominant in the oral cavity and upper airways. (2020)
  • Author(s): Domon H, Hiyoshi T, Maekawa T, Yonezawa D, Tamura H, Kawabata S, Yanagihara K, Kimura O, Kunitomo E, Terao Y
  • Journal Title: Microbiol Immunol Volume: 63 Pages: 213-222
  • Peer Reviewed
• [Journal Article] Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA. (2019)
  • Author(s): Yamaguchi M, Hirose Y, Takemura M, Ono M, Sumitomo T, Nakata M, Terao Y, Kawabata S
  • Journal Title: Front Cell Infect Microbiol Volume: 9 Pages: 301-301
  • Peer Reviewed
• [Journal Article] A peptide derived from rice inhibits alveolar bone resorption via suppression of inflammatory cytokine production. (2019)
  • Author(s): Aoki-Nonaka Y, Tabeta K, Yokoji M, Matsugishi A, Matsuda Y, Takahashi N, Sulijaya B, Domon H, Terao Y, Taniguchi M, Yamazaki K
  • Journal Title: J Periodontol Volume: 90(10) Pages: 1160-1169
  • Peer Reviewed
• [Journal Article] A horizontal sequential cutting method to estimate the effectiveness of dentin disinfection by using confocal laser scanning microscopy. (2019)
  • Author(s): Hasegawa T, Takenaka S, Wakamatsu R, Ohsumi T, Domon H, Ohshima H, Terao Y, Noiri Y
  • Journal Title: J Endod Volume: 45
  • Peer Reviewed
• [Journal Article] Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis. (2019)
  • Author(s): Hiyoshi T, Domon H, Maekawa T, Nagai K, Tamura H, Takahashi N, Yonezawa D, Miyoshi T, Yoshida A, Tabeta, K, Terao Y
  • Journal Title: Microbiol Immunol Volume: 63 Pages: 100-110
  • NAID: 40021899825
  • Peer Reviewed
• [Journal Article] Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children with acute otitis media in Japan from 2014 to 2017. (2019)
  • Author(s): Nagai K, Kimura O, Domon H, Maekawa T, Yonezawa D, Terao Y
  • Journal Title: J Infect Chemother Volume: 25(3) Pages: 229-232
  • Peer Reviewed
• [Journal Article] Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis. (2019)
  • Author(s): Tamura H, Maekawa T, Domon H, Hiyoshi T, Yonezawa D, Nagai K, Ochiai A, Taniguchi M, Tabeta K, Maeda T, Terao Y
  • Journal Title: Arch Oral Biol Volume: 98 Pages: 132-139
  • Peer Reviewed
• [Journal Article] Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection. (2019)
  • Author(s): Nagai K, Domon H, Maekawa T, Hiyoshi T, Tamura H, Yonezawa D, Habuka R, Saitoh A, Terao Y
  • Journal Title: Vaccine Volume: 37 Pages: 160-168
  • Peer Reviewed
• [Journal Article] Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria predominant in the oral cavity and upper airways. (2019)
  • Author(s): Domon, H., Hiyoshi, T., Maekawa, T., Yonezawa, D., Tamura, H., Kawabata, S., Yanagihara, K., Kimura, O., Kunitomo, E., and Terao, Y.
  • Journal Title: Microbiol. Immunol. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis. (2019)
  • Author(s): Hiyoshi, T., Domon, H., Maekawa, T., Nagai, K., Tamura, H., Takahashi, N., Yonezawa, D., Miyoshi, T., Yoshida, A., Tabeta, K., and Terao, Y.
  • Journal Title: Microbiol. Immunol. Volume: 印刷中
  • NAID: 40021899825
  • Peer Reviewed
• [Journal Article] The AmyI-1-18 peptide derived from rice inhibits alveolar bone resorption via suppression of inflammatory cytokine production induced by lipopolysaccharide and interleukin-1beta. (2019)
  • Author(s): Aoki-Nonaka, Y., Tabeta, K., Yokoji, M., Matsugishi, A., Matsuda, Y., Takahashi, N., Sulijaya, B., Domon, H., Terao, Y., Taniguchi, M., and Yamazaki, K.
  • Journal Title: J. Periodontol. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children with acute otitis media in Japan from 2014 to 2017. (2019)
  • Author(s): Nagai, K., Kimura, O., Domon, H., Maekawa, T., Yonezawa, D., and Terao, Y.
  • Journal Title: J. Infect. Chemother. Volume: 25(3) Pages: 229-232
  • Peer Reviewed
• [Journal Article] Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis. (2019)
  • Author(s): Tamura, H., Maekawa, T., Domon, H., Hiyoshi, T., Yonezawa, D., Nagai, K., Ochiai, A., Taniguchi, M., Tabeta, K., Maeda, T., and Terao, Y.
  • Journal Title: Arch. Oral Biol. Volume: 98 Pages: 132-139
  • Peer Reviewed
• [Journal Article] Repeated human deciduous tooth-derived dental pulp cell reprogramming factor transfection yields multipotent intermediate cells with enhanced iPS cell formation capability. (2019)
  • Author(s): Soda, M., Saitoh, I., Murakami, T., Inada, E., Iwase, Y., Noguchi, H., Shibasaki, S., Kurosawa, M., Sawami, T., Terunuma, M., Kubota, N., Terao, Y., Ohshima, H., Hayasaki, H., and Sato, M.
  • Journal Title: Scientific Reports Volume: 9 Pages: 1490-1490
  • Peer Reviewed
• [Journal Article] Mechanism of macrolide-induced inhibition of pneumolysin release involves impairment of autolysin release in macrolide-resistant Streptococcus pneumoniae. (2018)
  • Author(s): Domon, H., Maekawa, T., Yonezawa, D., Nagai, K., Oda, M., Yanagihara, K., and Terao, Y.
  • Journal Title: Antimicrob. Agents Chemother. Volume: 62(11)
  • Peer Reviewed
• [Journal Article] Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells. (2018)
  • Author(s): Kurosawa, M., Oda, M., Domon, H., Isono, T., Nakamura, Y., Saitoh, I., Hayasaki, H., Yamaguchi, M., Kawabata, S., and Terao, Y.
  • Journal Title: Microbiol. Immunol. Volume: 62 Pages: 617-623
  • NAID: 40021702611
  • Peer Reviewed
• [Journal Article] Neutrophil elastase subverts the immune response by cleaving toll-like receptors and cytokines in pneumococcal pneumonia. (2018)
  • Author(s): Domon, H., Nagai, K., Maekawa, T., Oda, M., Yonezawa, D., Takeda, W., Hiyoshi, T., Tamura, H., Yamaguchi, M., Kawabata, S., and Terao, Y.
  • Journal Title: Front. Immunol. Volume: Vol. 9
  • Peer Reviewed
• [Journal Article] Sulfated vizantin induces the formation of macrophage extracellular traps. (2018)
  • Author(s): Oda, M., Kurosawa, M., Yamamoto, H., Domon, H., Kimura, T., Isono, T., Maekawa, T., Hayashi, N., Yamada, N., Furue, Y., Kai, D., and Terao, Y.
  • Journal Title: Microbiol. Immunol. Volume: 62 Pages: 310-316
  • NAID: 40021560445
  • Peer Reviewed
• [Journal Article] The effect of chlorhexidine on dental calculus formation: an in vitro study (2018)
  • Author(s): Sakaue, Y., Takenaka, S., Ohsumi, T., Domon, H., Terao, Y., and Noiri, Y.
  • Journal Title: BMC Oral Health Volume: 18 Pages: 52-52
  • Peer Reviewed
• [Journal Article] treptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection. (2018)
  • Author(s): Sumitomo, T., Mori, Y., Nakamura, Y., Honda-Ogawa, M., Nakagawa, S., Yamaguchi, M., Matsue, H., Terao, Y., Nakata, M., and Kawabata, S.
  • Journal Title: Front. Cell. Infect. Microbiol. Volume: Vol. 8
  • Peer Reviewed
• [Journal Article] Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4. (2018)
  • Author(s): Nagai, K., Domon, H., Maekawa, T., Oda, M., Hiyoshi, T., Tamura, H., Yonezawa, D., Arai, Y., Yokoji, M., Tabeta, K., Habuka, R., Saitoh, A., Yamaguchi, M., Kawabata, S., and Terao, Y.
  • Journal Title: Cell. Immunol. Volume: 325 Pages: 14-22
  • Peer Reviewed
• [Journal Article] treptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway. (2018)
  • Author(s): Kurosawa, M., Oda, M., Domon, H., Isono, T., Nakamura, Y., Saitoh, I., Hayasaki, H., Yamaguchi, M., Kawabata, S., and Terao, Y.
  • Journal Title: Microb. Infect. Volume: 20 Pages: 9-18
  • Peer Reviewed
• [Journal Article] Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-like Receptors and Cytokines in Pneumococcal Pneumonia. (2018)
  • Author(s): Domon H, Nagai K, Maekawa T, Oda M, Yonezawa D, Takeda W, Hiyoshi T, Tamura H, Yamaguchi M, Kawabata S, Terao Y
  • Journal Title: Front Immunol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Sulfated vizantin induces the formation of macrophage extracellular traps. (2018)
  • Author(s): Oda M, Kurosawa M, Yamamoto H, Domon H, Kimura T, Isono T, Maekawa T, Hayashi N, Yamada N, Furue Y, Kai D, Terao Y
  • Journal Title: Microbiol Immunol Volume: 印刷中
  • NAID: 40021560445
  • Peer Reviewed
• [Journal Article] The effect of chlorhexidine on dental calculus formation: an in vitro study. (2018)
  • Author(s): Sakaue Y, Takenaka S, Ohsumi T, Domon H, Terao Y, Noiri Y
  • Journal Title: BMC Oral Health Volume: 18(1) Pages: 52-52
  • Peer Reviewed
• [Journal Article] Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection. (2018)
  • Author(s): Sumitomo T, Mori Y, Nakamura Y, Honda-Ogawa M, Nakagawa S, Yamaguchi M, Matsue H, Terao Y, Nakata M, Kawabata S
  • Journal Title: Front Cell Infect Microbiol Volume: 8 Pages: 10-10
  • Peer Reviewed
• [Journal Article] Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4. (2018)
  • Author(s): Nagai K, Domon H., Maekawa T, Oda M, Hiyoshi T, Tamura H, Yonezawa D, Arai Y, Yokoji M, Tabeta K, Habuka R, Saitoh A, Yamaguchi M, Kawabata S, Terao Y
  • Journal Title: Cell Immunol Volume: 325 Pages: 14-22
  • Peer Reviewed
• [Journal Article] Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway. (2018)
  • Author(s): Kurosawa M, Oda M, Domon H, Isono T, Nakamura Y, Saitoh I, Hayasaki H, Yamaguchi M, Kawabata S, Terao Y
  • Journal Title: Microb Infect Volume: 20 Pages: 9-18
  • Peer Reviewed
• [Journal Article] Streptococcus pyogenes phospholipase A2 induces the expression of adhesion molecules on human umbilical vein endothelial cells and aorta of mice. (2017)
  • Author(s): Oda M, Domon H, Kurosawa M, Isono T, Maekawa T, Yamaguchi M, Kawabata S, Terao Y
  • Journal Title: Front Cell Infect Microbiol Volume: 7 Pages: 300-300
  • Peer Reviewed
• [Journal Article] Differential expression and roles of secreted frizzled-related protein 5 （Sfrp5）and the wingless homolog Wnt5a in periodontitis. (2017)
  • Author(s): Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Oda M, Terao Y, Maeda T, Hajishengallis G
  • Journal Title: J Dent Res Volume: 96 Pages: 571-577
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers. (2017)
  • Author(s): Murakami T, Saitoh I, Sato M, Inada E, Soda M, Oda M, Domon H, Iwase Y, Sawami T, Matsueda K, Terao Y, Ohshima H, Noguchi H, Hayasaki H
  • Journal Title: Arch Oral Biol Volume: 81 Pages: 110-120
  • Peer Reviewed
• [Presentation] 新規肺炎制御法開発への展開肺炎球菌の新規治療戦略 (2020)
  • Author(s): 土門久哲
  • Organizer: 第93回日本細菌学会総会
  • Invited
• [Presentation] Erythromycin suppresses inflammatory bone loss through reinduction of DEL-1 (2019)
  • Author(s): Tamura H, Maekawa T, Domon H, Hiyoshi T, Yonezawa D, Nagai K, Maeda T, Terao Y, Tabeata K
  • Organizer: The 98th General Session of the International Association for Dental Researc
  • Int'l Joint Research
• [Presentation] Aggregatibacter actinomycetemcomitans Leukotoxin Induce Periodontal Tissue Destruction Via Neutrophil Elastase, (2019)
  • Author(s): Hiyoshi T, Domon H, Maekawa T, Tamura H, Yonezawa D, Terao Y, Tabeta K
  • Organizer: The 98th General Session of the International Association for Dental Researc
  • Int'l Joint Research
• [Presentation] 新規肺炎制御法開発への展開 (2019)
  • Author(s): 土門久哲
  • Organizer: 第92回日本細菌学会総会
  • Invited
• [Presentation] 肺炎球菌性肺炎の重症化メカニズム解析―新たな肺炎制御法の開発を目指して― (2019)
  • Author(s): 土門久哲
  • Organizer: 第31回微生物シンポジウム
  • Invited
• [Presentation] Immunization with pneumococcal EF-Tu enhances serotype independent protection against S. pneumoniae (2019)
  • Author(s): 永井康介，土門久哲，前川知樹，日吉 巧，田村 光，寺尾 豊
  • Organizer: 第92回日本細菌学会総会
• [Presentation] Analysis of periodontal tissue destruction induced by A. actinomycetemcomitans leukotoxin (2019)
  • Author(s): 日吉 巧，土門久哲，前川知樹，永井康介，田村 光，寺尾 豊
  • Organizer: 第92回日本細菌学会総会
• [Presentation] エリスロマイシンのDel-1再誘導による炎症性骨吸収抑制効果の検証 (2019)
  • Author(s): 田村 光，前川知樹，土門久哲，日吉 巧，米澤大輔，永井康介，前田健康，寺尾 豊，多部田康一
  • Organizer: 第62回春季歯周病学会学術大会
• [Presentation] Aggregatibacter actinomycetemcomitansによる歯周炎重症化メカニズムの解析 (2019)
  • Author(s): 日吉 巧，土門久哲，前川知樹，永井康介，田村 光，高橋直紀，吉田明弘，寺尾 豊，多部田康一
  • Organizer: 第62回春季歯周病学会学術大会
• [Presentation] コメ由来ペプチドAmyI-1-18，アミノ酸置換体がPorphyromonas gingivalisバイオフィルムに及ぼす影響 (2019)
  • Author(s): 松岸 葵，野中由香莉，竹内麻衣，原 実生，土門久哲，山崎和久，多部田康一
  • Organizer: 第62回春季歯周病学会学術大会
• [Presentation] 米由来ペプチドによる炎症制御機構の検索と歯周病治療への応用研究 (2019)
  • Author(s): 田村 光，前川知樹，土門久哲，日吉 巧，米澤大輔，前田健康，多部田康一，寺尾 豊
  • Organizer: 新潟歯学会
• [Presentation] 宿主―細菌相互作用による肺炎重症化メカニズム解析 (2019)
  • Author(s): 土門久哲，永井康介，山口雅也，川端重忠，寺尾 豊
  • Organizer: 第13回細菌学若手コロッセウム
• [Presentation] エリスロマイシンのDel-1再誘導による炎症性骨吸収抑制効果の解析 (2019)
  • Author(s): 田村 光，前川知樹，土門久哲，米澤大輔，前田健康，多部田康一，寺尾 豊
  • Organizer: 第７回口腔微生物研究会
• [Presentation] Local regulator Del1 inhibits bone-resorption via suppression of Wnt5a-Ror2 signaling axis. (2018)
  • Author(s): Maekawa T, Domon H, Kobayashi K, Nagai K, Yonezawa D, Maeda T, Hajishengallis G, Terao Y.
  • Organizer: he ASBMR 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] 内因性抗炎症Del-1分子誘導による炎症性骨破壊の新規治療戦略 (2018)
  • Author(s): 前川知樹，土門久哲，田村 光，日吉 巧，寺尾 豊，前田健康
  • Organizer: 第61回秋季日本歯周病学会学術大会
• [Presentation] 腔および上気道の病原細菌に対するヒノキチオールの抗菌作用解析 (2018)
  • Author(s): 土門久哲，國友栄治，寺尾 豊
  • Organizer: 第60回歯科基礎医学会学術大会
• [Presentation] 炎症および骨吸収の制御作用を有する新規食物由来ペプチドの検索 (2018)
  • Author(s): 田村 光，前川知樹，土門久哲，永井康介，日吉 巧，前田健康，寺尾 豊
  • Organizer: 第60回歯科基礎医学会学術大会
• [Presentation] Local regulator Del1 inhibits bone-resorption via suppression of Wnt5a-Ror2 signaling axis. (2018)
  • Author(s): Maekawa T, Domon H, Kobayashi K, Nagai K, Yonezawa D, Terao Y, Maeda T, Hajishengallis G.
  • Organizer: 96th General Session & Exhibition of the IADR
  • Int'l Joint Research
• [Presentation] 内因性抗炎症分子Del-1分子誘導による炎症性骨破壊の新規治療戦略 (2018)
  • Author(s): 前川知樹，小林泰浩，土門久哲，田村 光，日吉 巧，永井康介，寺尾 豊，前田健康
  • Organizer: 第4回日本骨免疫学会
• [Presentation] 食物由来ペプチドを用いた炎症と骨吸収の制御法の検索 (2018)
  • Author(s): 田村 光，前川知樹，米沢大輔，土門久哲，永井康介，日吉 巧，多部田康一，前田健康，寺尾 豊，吉江弘正
  • Organizer: 第61回春季日本歯周病学会学術大会
• [Presentation] Aggregatibacter actinomycetemcomitansによる歯周組織破壊メカニズムの解析 (2018)
  • Author(s): 日吉 巧，土門久哲，永井康介，前川知樹，高橋直紀，米沢大輔，田村 光，吉田明弘，寺尾 豊，吉江弘正
  • Organizer: 第61回春季日本歯周病学会学術大会
• [Presentation] 肺炎球菌性肺炎の重症化メカニズムの解析－新規肺炎制御法への展開－ (2018)
  • Author(s): 土門久哲，永井康介，前川知樹，山口雅也，川端重忠，寺尾 豊
  • Organizer: 第6回五大学・口腔微生物研究会
• [Presentation] Aggregatibacter actinomycetemcomitansが産生するロイコトキシンによる歯周組織破壊メカニズムの解析 (2018)
  • Author(s): 日吉巧，土門久哲，永井康介，前川知樹，高橋直紀，米澤大輔，田村光，吉田明弘，寺尾 豊
  • Organizer: 第6回五大学・口腔微生物研究会
• [Presentation] 肺炎球菌とマクロライド：新潟市内の耐性菌分離率と病原性抑制作用の解析 (2018)
  • Author(s): 土門久哲，前川知樹，永井康介，栁原克紀，木村 征，寺尾 豊
  • Organizer: 第57回新潟化学療法研究会学術講演会
• [Presentation] マクロライド耐性肺炎球菌に対するマクロライド系抗菌薬の作用解析 (2018)
  • Author(s): 土門久哲，前川知樹，永井康介，栁原克紀，木村 征，寺尾 豊
  • Organizer: 第25回マクロライド新作用研究会
• [Presentation] 内因性抗炎症分子Del-1を介したマクロライド系抗菌薬の新作用機序 (2018)
  • Author(s): 前川知樹，土門久哲，寺尾 豊
  • Organizer: 第25回マクロライド新作用研究会
• [Presentation] 肺炎球菌性肺炎の重症化カスケード ―細菌由来病原因子と好中球由来防御因子のせめぎ合い― (2018)
  • Author(s): 土門久哲，寺尾 豊
  • Organizer: 第91回日本細菌学会総
  • Invited
• [Presentation] Pneumococcal DNA-binding proteins released by autolysis induce inflammatory cytokine production (2018)
  • Author(s): 永井康介，土門久哲，前川知樹，山口雅也，川端重忠，寺尾 豊
  • Organizer: 第91回日本細菌学会総会
• [Presentation] 口腔領域の病原細菌に対するヒノキチオールの抗菌作用解析 (2018)
  • Author(s): 土門久哲，國友栄治，寺尾 豊
  • Organizer: 第91回日本細菌学会総会
• [Presentation] Streptococcal cysteine protease-mediated cleavage of desmogleins contributes to development of cutaneous infections. (2017)
  • Author(s): Sumitomo T, Mori Y, Nakamura Y, Honda-Ogawa M, Yamaguchi M, Terao Y, Nakata M, Kawabata S
  • Organizer: IUMS 2017
  • Int'l Joint Research
• [Presentation] Differential Expression and Roles of Sfrp5 and Wnt5a in Periodontitis. (2017)
  • Author(s): Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Terao Y, Maeda T, Hajishengallis G
  • Organizer: 95th General Session & Exhibition of the IADR
  • Int'l Joint Research
• [Presentation] 抗炎症性分子 Del-1 は Wnt5a-Ror2 伝達経路を阻害し骨吸収を抑制する (2017)
  • Author(s): 前川知樹，小林泰浩，土門久哲，永井康介，寺尾 豊，前田健康
  • Organizer: 第59回歯科基礎医学会学術大会
• [Presentation] 自己溶菌に伴い放出される肺炎球菌の菌体内病原因子の同定と分子解析 (2017)
  • Author(s): 永井康介，土門久哲，前川知樹，山口雅也，川端重忠，寺尾 豊
  • Organizer: 第59回歯科基礎医学会学術大会
• [Presentation] 肺炎の重症化に伴い誘導される宿主由来エラスターゼの病原性解析 (2017)
  • Author(s): 土門久哲，前川知樹，永井康介，山口雅也，川端重忠，寺尾 豊
  • Organizer: 第59回歯科基礎医学会学術大会
• [Presentation] ヒト好中球を利用する肺炎球菌の感染メカニズム解析 (2017)
  • Author(s): 土門久哲，前川知樹，永井康介，寺尾 豊
  • Organizer: 第１回 オーラルサイエンス研究会
• [Presentation] 食物由来ペプチドを用いた炎症と骨吸収制御機構の検索 (2017)
  • Author(s): 田村 光, 前川知樹，米澤大輔，土門久哲，永井康介，日吉 巧，前田健康，寺尾 豊
  • Organizer: 第5回五大学・口腔微生物研究会
• [Presentation] Aggregatibacter actinomycetemcomitans leukotoxin およびcytolethal distending toxin 組換え体の宿主細胞に対する作用解析 (2017)
  • Author(s): 日吉 巧，土門久哲，永井康介，前川知樹，米澤大輔，田村 光，吉田明弘，寺尾 豊
  • Organizer: 第5回五大学・口腔微生物研究会
• [Presentation] 自己溶菌で漏出する肺炎球菌の菌体内病原因子の検索 (2017)
  • Author(s): 永井康介，土門久哲，前川知樹，横地麻衣，多部田康一，寺尾 豊
  • Organizer: 第49回レンサ球菌研究会
• [Presentation] 肺炎球菌が誘導する宿主由来エラスターゼによる自然免疫抑制メカニズム (2017)
  • Author(s): 土門久哲，前川知樹，永井康介，寺尾 豊
  • Organizer: 第49回レンサ球菌研究会
• [Presentation] Streptococcus pyogengesの咽頭上皮細胞株への付着・侵入におけるCAMP factorとPI3K/Akt経路との関係 (2017)
  • Author(s): 黒澤美絵，小田真隆，土門久哲，斎藤一誠，早﨑治明，寺尾 豊
  • Organizer: 第49回レンサ球菌研究会
• [Presentation] Streptococcus pyogenges PLA2による血管内皮細胞への単球付着メカニズム (2017)
  • Author(s): 磯野俊仁，小田真隆，土門久哲，前川知樹，黒澤美絵，寺尾 豊
  • Organizer: 第49回レンサ球菌研究会
• [Book] 新版 歯学生のための摂食嚥下リハビリテーション学 (2020)
  • Author(s): 寺尾 豊（分担執筆）
  • Total Pages: 291
  • Publisher: 医歯薬出版
• [Book] 口腔微生物学・免疫学 第４版第５刷 (2020)
  • Author(s): 寺尾 豊（分担執筆）
  • Total Pages: 303
  • Publisher: 医歯薬出版
• [Book] 歯科衛生士書き込み式学習ノート?@ 専門基礎科目編 第２版第２刷 (2020)
  • Author(s): 寺尾 豊（分担執筆）
  • Total Pages: 301
  • Publisher: 医歯薬出版
• [Book] パーフェクトマスター口腔微生物学・免疫学 改訂増刷版 (2020)
  • Author(s): 寺尾 豊
  • Total Pages: 93
  • Publisher: 医歯薬出版
• [Book] Update on the Immune Mechanisms Against Respiratory Pathogens (2019)
  • Author(s): Domon H, Nagai K, Maekawa T, Oda M, Yonezawa D, Takeda W, Hiyoshi T, Tamura H, Yamaguchi M, Kawabata S, Terao Y
  • Total Pages: 355
  • Publisher: Frontiers e-book
• [Book] 日本歯科評論：米ペプチドを用いた歯槽骨吸収の抑制 (2019)
  • Author(s): 寺尾 豊
  • Total Pages: 190
  • Publisher: ヒョーロン・パブリッシャーズ社
• [Book] 日本歯科評論：誤嚥性肺炎の分子制御に向けて (2019)
  • Author(s): 寺尾 豊
  • Total Pages: 182
  • Publisher: ヒョーロン・パブリッシャーズ社
• [Book] 日本歯科評論：歯周病における歯肉細胞損傷メカニズムとその制御研究 (2019)
  • Author(s): 寺尾 豊
  • Publisher: ヒョーロン・パブリッシャーズ社
• [Book] パーフェクトマスター口腔微生物学・免疫学 (2018)
  • Author(s): 寺尾 豊
  • Total Pages: 93
  • Publisher: 医歯薬出版
• [Book] 微生物学，歯科衛生士 歯科衛生士書き込み式学習ノート① (2018)
  • Author(s): 寺尾 豊
  • Total Pages: 298
  • Publisher: 医歯薬出版
• [Book] 微生物学，歯科衛生士書き込み式学習ノート① 専門基礎科目編 人体の構造と機能／歯・口腔の構造と機能／疾病の成り立ち及び回復過程の促進 (2018)
  • Author(s): 寺尾 豊
  • Total Pages: 294
  • Publisher: 医歯薬出版
• [Book] 口腔微生物学・免疫学 第４版第３刷改訂版 (2018)
  • Author(s): 川端重忠，小松澤 均，大原直也，寺尾 豊，浜田茂幸
  • Total Pages: 303
  • Publisher: 医歯薬出版
• [Remarks] 肺炎球菌の病原因子および細菌性肺炎重症化機構の解析
  • URL: https://nu-mid.net/study/index4.html