Research Project
Grant-in-Aid for Scientific Research (B)
It has long been known that pneumococci perform autolysis. In addition, recent pathological diagnosis has revealed that a large amount of neutrophils infiltrate human pneumococcal infection sites. Furthermore, it has been reported that the infectious disease specialists in Japan and overseas can reduce the severity of pneumonia by administering an inhibitor of neutrophil endogenous protease. However, there was no research paper that integrated and elucidated them. Therefore, we carried out the mass spectrometric analysis on the molecular mechanism by which pneumonia becomes severe from two directions: the pneumococcal side and the human neutrophil side. Then, we integrated the elucidation data of the pneumococcal side and the human side, and identified a group of molecular candidates involved in the severity of pneumonia
誤嚥性肺炎を含めた肺炎は,耐性菌の出現と高齢社会を迎え増加・重症化している.2016年以降,日本政府および国連が,具体名を挙げて肺炎を人類の最脅威のひとつに定義している.WHOならびに国連の最新試算では,抗菌薬以外の対策を考案できなければ,2050年以降は毎年1000万人の死者が出ると予測されている.本研究の結果,肺炎球菌だけが好中球を敢えて周囲に集積させて好中球を傷害し,同細胞の内容物を利用して感染拡大を行うユニークな知見を掴んだ.今後は本研究成果に加え,好中球を利用する肺炎球菌の病原機構を詳細解析し,その制御法へと繋げることができる.
All 2020 2019 2018 2017 Other
All Journal Article (38 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 38 results) Presentation (41 results) (of which Int'l Joint Research: 6 results, Invited: 4 results) Book (12 results) Remarks (1 results)
Microbiol. Immunol.
Volume: in press
Microbiol Immunol
J Infect Dis
Biofouling
Methods Mol Biol
Arch Oral Biol
Volume: 112(4) Pages: 104679-104679
Clin Oral Investig
Volume: 24(2) Pages: 963-970
Volume: 63 Pages: 213-222
Front Cell Infect Microbiol
Volume: 9 Pages: 301-301
J Periodontol
Volume: 90(10) Pages: 1160-1169
J Endod
Volume: 45
Volume: 63 Pages: 100-110
40021899825
J Infect Chemother
Volume: 25(3) Pages: 229-232
Volume: 98 Pages: 132-139
Vaccine
Volume: 37 Pages: 160-168
Volume: 印刷中
J. Periodontol.
J. Infect. Chemother.
Arch. Oral Biol.
Scientific Reports
Volume: 9 Pages: 1490-1490
Antimicrob. Agents Chemother.
Volume: 62(11)
Volume: 62 Pages: 617-623
40021702611
Front. Immunol.
Volume: Vol. 9
Volume: 62 Pages: 310-316
40021560445
BMC Oral Health
Volume: 18 Pages: 52-52
Front. Cell. Infect. Microbiol.
Volume: Vol. 8
Cell. Immunol.
Volume: 325 Pages: 14-22
Microb. Infect.
Volume: 20 Pages: 9-18
Front Immunol
Volume: 18(1) Pages: 52-52
Volume: 8 Pages: 10-10
Cell Immunol
Microb Infect
Volume: 7 Pages: 300-300
J Dent Res
Volume: 96 Pages: 571-577
Volume: 81 Pages: 110-120
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