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Induction of periodontal ligaments on titanium implants mimicking nanotopography of cementum

Research Project

Project/Area Number 17H04387
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionTohoku University

Principal Investigator

Masahiro Yamada  東北大学, 歯学研究科, 准教授 (90549982)

Co-Investigator(Kenkyū-buntansha) 江草 宏  東北大学, 歯学研究科, 教授 (30379078)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Keywords歯科補綴学 / 細胞・組織 / 再生医学
Outline of Final Research Achievements

The purpose of this study is to create the titanium nano-surface mimicking a cementitious surface and to induce cementum on the titanium implant through regulation of periodontal ligament cells. Cementum mimetic titanium nano-surface might reconstruct the periodontal tissue with cementum formation on the titanium implant in the presence of mesenchymal stem cells and periodontal ligament matrix.

Academic Significance and Societal Importance of the Research Achievements

本研究は,インプラント周囲組織の歯周組織化という困難な生体医工学的課題に対して,生体模倣概念を導入したインプラント表面改質による組織誘導というアプローチで解決を試みている点が斬新で独創性に富んでいる.本ナノ表面は簡便な方法で作製可能であること,また,歯根膜細胞は比較的採取しやすい細胞であることから,本研究が達成されれば,歯根膜を獲得したインプラント実現のための組織工学技術的および法規制的課題の多くを解決し,歯科補綴治療を革命的に進化させる可能性がある.さらに,歯科補綴学やインプラント学のみならず再生歯学や生体材料学,細胞生物学の学問的発展にも貢献し得る意義深い研究課題である.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (18 results)

All 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (11 results) (of which Int'l Joint Research: 4 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] UCLA School of Dentistry(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Cytoprotective Preconditioning of Osteoblast-Like Cells with N-Acetyl-L-Cysteine for Bone Regeneration in Cell Therapy.2019

    • Author(s)
      Yamada M, Watanabe J, Ueno T, Ogawa T, Egusa H.
    • Journal Title

      Int J Mol Sci.

      Volume: 20 Issue: 20 Pages: 5199-5199

    • DOI

      10.3390/ijms20205199

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preconditioning of bone marrow-derived mesenchymal stem cells with N-acetyl-L-cysteine enhances bone regeneration via reinforced resistance to oxidative stress2018

    • Author(s)
      Watanabe Jun、Yamada Masahiro、Niibe Kunimichi、Zhang Maolin、Kondo Takeru、Ishibashi Minoru、Egusa Hiroshi
    • Journal Title

      Biomaterials

      Volume: 185 Pages: 25-38

    • DOI

      10.1016/j.biomaterials.2018.08.055

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current bone substitutes for implant dentistry2018

    • Author(s)
      Yamada M, Egusa H
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 62 Issue: 2 Pages: 152-161

    • DOI

      10.1016/j.jpor.2017.08.010

    • NAID

      130006733089

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Biomimetic Titanium Nano-surfaces Promote Induction of Periodontal Ligaments.2019

    • Author(s)
      Yamada M, Kimura T, Nakamura N, Yoshioka H, Shinno H, Egusa H.
    • Organizer
      The 2019 IADR/AADR/CADR General Session & Exhibition
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体模倣ナノ表面改質を施したチタンインプラントによる歯周組織の誘導2019

    • Author(s)
      山田将博
    • Organizer
      第6回 MatriCell フォーラム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Replication methods of titanium surface topography2019

    • Author(s)
      Yamada M, Kimura T, Nakamura N, Egusa H.
    • Organizer
      The 4th International Symposium on Biomedical Engineering
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歯周組織を誘導する生体模倣チタンナノ表面インプラントの開発2019

    • Author(s)
      山田将博,吉岡勇人,新野秀憲,木村 剛,中村奈緒子,江草 宏
    • Organizer
      平成30年度生体医歯工学共同研究拠点成果報告会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Redox biology-based preconditioning of MSCs to assist bone regeneration.2018

    • Author(s)
      Watanabe J, Yamada M, Niibe K, Maolin T, Kondo H, Egusa H.
    • Organizer
      96th general session and exhibition of the IADR IADR Pan European regional congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] バイオミメティックインプラントによる軟組織付着獲得への挑戦2018

    • Author(s)
      山田将博
    • Organizer
      第48回日本口腔インプラント学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] N-acetyl-L-cysteine Reinforces Apoptosis Resistance of MSCs to Promote Bone Regeneration.2018

    • Author(s)
      Yamada M, Kimura T, Nakamura N, Egusa H.
    • Organizer
      The 3rd International Symposium on Biomedical Engineering
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歯根セメント質表面の微小硬度と表面形態の評価2018

    • Author(s)
      山田将博,吉岡勇人,新野秀憲,江草 宏
    • Organizer
      平成29年度生体医歯工学共同研究拠点成果報告
    • Related Report
      2017 Annual Research Report
  • [Presentation] Redox biology-based strategy in bone regeneration for efficient transplantation of osteoblastic cells.2017

    • Author(s)
      Watanabe J, Yamada M, Egusa H.
    • Organizer
      International meeting the 7th Temu Ilmiah Nasional and 4th Scientific Meeting in Dentistry
    • Related Report
      2017 Annual Research Report
  • [Presentation] インプラント表面性状の解釈とその骨結合能を推測する方法2017

    • Author(s)
      山田将博
    • Organizer
      平成29年度(公社)日本補綴歯科学会 東北・北海道支部学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] N-acetyl-L-cysteine Reinforces Apoptosis Resistance of MSCs to Promote Bone Regeneration.2017

    • Author(s)
      Watanabe J, Yamada M, Egusa H.
    • Organizer
      Hatton competition in Japanese Association for Dental Research 65th Annual Meeting
    • Related Report
      2017 Annual Research Report
  • [Book] The Fabric of the Modern Implantology 近代インプラント治療のテクニックとサイエンス2017

    • Author(s)
      船登彰芳,山田将博,吉松繁人
    • Total Pages
      240
    • Publisher
      医歯薬出版株式会社
    • ISBN
      9784263461358
    • Related Report
      2017 Annual Research Report
  • [Remarks] 東北大学大学院歯学研究科 分子・再生歯科補綴学分野ホームページ

    • URL

      http://crbr.dent.tohoku.ac.jp/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] ​東北大学 大学院歯学研究科 分子・再生歯科補綴学分野ホームページ

    • URL

      http://crbr.dent.tohoku.ac.jp/

    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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