Japan-U.S. joint Research for establishment of international disease concept and new diagnostic criteria of IgG4-related disease
| Project/Area Number |
17H04671
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 康晴 岡山大学, 保健学研究科, 教授 (00579831)
中村 誠司 九州大学, 歯学研究院, 教授 (60189040)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Keywords | IgG4関連疾患 / 日米国際共同研究 / 診断基準 / 国際共同研究 / 国際的疾患概念 / 日米共同研究 / ヘルパーT細胞 / 自然免疫 / 病態 |
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| Outline of Final Research Achievements |
We performed the exhaustive gene expression analysis using by the salivary glands from Japanese and American IgG4-related disease. MMP9 and CCL18 were extracted as differentially expressed genes. PCR validated significantly higher expression of CCL18. Immunohistochemical analysis confirmed that the expression pattern of CCL18 was similar to that of the M2 macrophage marker CD163.
CCL18 was identified as a disease-associated molecule in IgG4-RD by DNA microarray. Moreover, M2 macrophages might contribute to the initiation of IgG4-RD via CCL18
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| Academic Significance and Societal Importance of the Research Achievements |
IgG4関連疾患は新規疾患であることから、その研究拠点はきわめて限定的であり、さらに臨床所見および研究結果にも本邦と海外では差異がある。そこで本研究では、欧米の研究拠点である米国のRagon 研究所と共同で、人種間の臨床統計および免疫学的検討を行った。その結果、日米共通の疾患関連分子（CCL18）を同定しており、今後は再発の多いステロイド治療に代わる新しい分子標的治療の開発が期待される。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Activated M2 macrophage contributes to the pathogenesis of IgG4-related disease via TLR7/IL-33 signalin.2019
Author(s)
Ishiguro N, Moriyama M, Furusho K, Furukawa S, Shibata T, Murakami Y, Chinju A, Haque ASMR, Gion Y, Ohta M, Maehara T, Tanaka A, Yamauchi M, Sakamoto M, Mochizuki K, Ono Y, Hayashida JN, Sato Y, Kiyoshima T, Yamamoto H, Miyake K, Nakamura S
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Journal Title
Arthritis Rheumatol.
Volume: Jan;72(1)
Issue: 1
Pages: 166-178
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The expansion in lymphoid organs of IL-4+ BATF+ T follicular helper cells is linked to IgG4 class switching in vivo2018
Author(s)
Maehara T, Mattoo H, Mahajan VS , Murphy SJH , Yuen GJ, Ishiguro N, Ohta M, Moriyama M, Saeki T, Yamamoto H, Yamauchi M, Daccache J, Kiyoshima T, Nakamura S, Stone JH, Pillai S.
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Journal Title
Life Science Alliance
Volume: 印刷中
Issue: 1
Pages: e201800050-e201800050
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease.2017
Author(s)
Furukawa S, Moriyama M, Miyake K, Nakashima H, Tanaka A, Maehara T, Iizuka-Koga M, Tsuboi H, Hayashida JN, Ishiguro N, Yamauchi M, Sumida T, Nakamura S
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 42413-42413
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] IL-1 inducing inflammation by CD163+ M2 macrophages contributes to the fibrosis of IgG4-related disease via TLR7/IRAK4/NFkB signaling.2021
Author(s)
Akira Chinju, Masafumi Moriyama, Noriko Ishiguro, Miho Ohta, Takashi Maehara, Akihiko Tanaka, Mizuki Sakamoto, Haque A.S.M. Rafiul, Keita Mochizuki, Yuko Ono, Ryusuke Munemura, Jun-Nosuke Hayashida, Seiji Nakamura
Organizer
Oral Bioscience & OBT Research Center Joint International Symposium 2021
Related Report
Int'l Joint Research / Invited
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[Presentation] Usefulness of labial salivary gland biopsy for the diagnosis and estimation of disease activity of IgG4-related disease2018
Author(s)
Mizuki Sakamoto, Masafumi Moriyama, Noriko Ishiguro, Yurie Mikami, Akihiko Tanaka, Takashi Maehara, Sachiko Furukawa, Miho Ohta, Masaki Yamauchi, Haque A. S. M. Rafiul, Akira Chinju, Keita Mochizuki, Ryusuke Munemura, Jun-Nosuke Hayashida, and Seiji Nakamura
Organizer
14th International Sjogren's Symposium
Related Report
Int'l Joint Research
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