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Neural mechanisms underlying inhibition of habits

Research Project

Project/Area Number 17H04749
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Developmental mechanisms and the body works
Research InstitutionTohoku University (2022)
Okinawa Institute of Science and Technology Graduate University (2017-2019)

Principal Investigator

Aoki Sho  東北大学, 生命科学研究科, 助教 (80720672)

Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Keywords線条体 / アセチルコリン / 習慣的動作 / 大脳基底核 / 習慣 / 行動 / 動作 / イメージング / 手続き記憶 / マウス / 動作の癖 / 大脳皮質 / 上丘 / 手続き学習 / 前頭前野 / 習慣的行動 / 小脳 / 動物モデル / 神経活動操作 / 動きの癖
Outline of Final Research Achievements

I have investigated neural mechanisms underlying suppression of habitual motor behavior. First, I developed an operant conditioning paradigm in which rats need to inhibit or switch a habitual movement. To investigate its mechanism, I focused on striatal cholinergic interneurons and found its role in modifying habitual motor behavior. For further investigation of the neural mechanism, I decided to use mice as it enables to apply various approaches of molecular biology and genetics, and developed another version of the action sequencing task in mice. In summary, the outcome of this research contributes to our understanding of how animals suppress or modify a habitual movement, and provide a foundation to future studies to investigate its neural underpinnings.

Academic Significance and Societal Importance of the Research Achievements

動作の癖はどのようにすれば直すことが出来るのか。この問題は、スポーツ指導や学校教育現場において、競技者のみならず指導者が直面する難題である。本研究は、動物モデルを用いて動きの癖を抑制・改善する神経メカニズムの解明に挑んだ。その結果、大脳基底核・線条体で神経伝達物質アセチルコリンを放出するコリン作動性介在ニューロンが重要な役割を果たすことが明らかになった。これは習慣化した動作の抑制・切り替えを担う神経メカニズムの一端を明らかにした重要研究知見といえる。今後、より詳細なメカニズムを解明していくことで、動作の癖を直す神経機構の基本的理解が進むことが期待される。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (15 results)

All 2019 2018 2017 Other

All Int'l Joint Research (5 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (5 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Int'l Joint Research] Salk Institute for Biological Studies(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Erasmus Medical Center Rotterdam(オランダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Salk Institute for Biological Studies(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Erasmus Medical Center(オランダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Salk Insititute(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway2019

    • Author(s)
      Sho Aoki, Jared B. Smith, Hao Li, Xunyi Yan, Masakazu Igarashi, Patrice Coulon, Jeffery R. Wickens, Tom J.H. Ruigrok, Xin Jin
    • Journal Title

      eLife

      Volume: 8 Pages: 49995-49995

    • DOI

      10.7554/elife.49995

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cerebellar modules and their role as operational cerebellar processing units.2018

    • Author(s)
      Richard Apps, Richard Hawkes, Sho Aoki, Amanda M. Brown, Gang Chen, Timothy J. Ebner, Philippe Isope, Elizabeth P. Lackey, Charlotte Lawrenson, Bridget Lumb, Martijn Schonewille, Roy V. Sillitoe, Ludovic Spaeth, Izumi Sugihara, Antoine Valera, Jan Voogd, Douglas R. Wylie Tom J.H. Ruigrok
    • Journal Title

      The Cerebellum

      Volume: 17 Issue: 5 Pages: 654-682

    • DOI

      10.1007/s12311-018-0952-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cholinergic interneurons in the rat striatum modulate substitution of habits2018

    • Author(s)
      Sho Aoki, Andrew W. Liu, Yumiko Akamine, Aya Zucca, Stefano Zucca, Jeffery R. Wickens
    • Journal Title

      European Journal of Neuroscience

      Volume: 47 Issue: 10 Pages: 1194-1205

    • DOI

      10.1111/ejn.13820

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo2018

    • Author(s)
      Zucca Stefano、Zucca Aya、Nakano Takashi、Aoki Sho、Wickens Jeffery
    • Journal Title

      eLife

      Volume: 7

    • DOI

      10.7554/elife.32510

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multizonal Cerebellar Influence Over Sensorimotor Areas of the Rat Cerebral Cortex2017

    • Author(s)
      Aoki Sho、Coulon Patrice、Ruigrok Tom J H
    • Journal Title

      Cerebral Cortex

      Volume: in press Issue: 2 Pages: 598-614

    • DOI

      10.1093/cercor/bhx343

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Linking emotion to motion: an open cortico-basal ganglia loop allows limbic control over motor output2019

    • Author(s)
      Sho Aoki
    • Organizer
      Neuro2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Linking emotion to motion: novel interaction across “limbic” and “motor” cortico-basal ganglia loops.2019

    • Author(s)
      Sho Aoki
    • Organizer
      OIST workshop: Neural Circuits for Motor Behavior
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multiple viral tracings reveal an anatomical hierarchy in cortico-basal ganglia loops.2018

    • Author(s)
      Sho Aoki, Jared. B Smith, Masakazu Igarashi, Patrice Coulon, Jeffery R. Wickens, Xin Jin, Tom J.H. Ruigrok.
    • Organizer
      Society for Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anatomical evidence that multiple striatal regions influence motor cortex.2017

    • Author(s)
      Sho Aoki, Masakazu Igarashi, Patrice Coulon, Jeffery R. Wickens, Tom J.H. Ruigrok
    • Organizer
      Society for Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anatomical evidence that multiple striatal regions influence motor cortex in the rat.2017

    • Author(s)
      Sho Aoki, Masakazu Igarashi, Patrice Coulon, Jeffery R. Wickens, Tom J.H. Ruigrok
    • Organizer
      Procedural Learning Summer School
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2024-01-30  

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