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Nanowire/pore device for selective particle separation, stepwise particle desorption, and single particle detection

Research Project

Project/Area Number 17H04803
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Nanobioscience
Research InstitutionNagoya University

Principal Investigator

Yasui Takao  名古屋大学, 工学研究科, 准教授 (00630584)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Keywordsナノワイヤ / マイクロ/ナノポア / ナノ材料 / ナノ空間 / 1分子計測 / ポアデバイス / ナノ界面 / 1分子科学 / ナノバイオ / マイクロヒーター / ヒーターデバイス
Outline of Final Research Achievements

Since a number of extracellular micro/nanoparticles with various size distribution are hazardous to our health, a way to identify these hazardous particles is strongly desired. However, conventional methodologies could not satisfy the requirement to identify the hazardous micro/nanoparticles, and we still feel vaguely insecure about the particles. In this research, we proposed a methodology to demonstrate selective separation, stepwise desorption, and single molecule detection using a nanowire/pore device. And then, we had a goal to achieve detection of the hazardous particles from "real" samples with various contaminants. Finally, the proposed methodology allows us to detect extracellular particles in our surroundings.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的な特色・独創的な点は、本手法でしか成し得ない物質の選択的分離・段階的脱離・1分子検出法を、ナノワイヤ/ポアデバイスを集積化した1つのデバイスにより創出するとともに、多種多様な夾雑物が混在するサンプルから極微量有害・危険物質(PM2.5/細菌/ウイルス等)の同時検知を実現するシステムを開発するところにある。また、本研究成果の社会的意義は、身の回りに存在する多種多様な極微量有害・危険物質に対する漠然とした不安を取り除き、これまでの有害・危険物質に対する認識を根底から覆すといった波及効果である。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (57 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (5 results) Journal Article (14 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 14 results,  Open Access: 9 results) Presentation (17 results) (of which Int'l Joint Research: 3 results,  Invited: 17 results) Book (4 results) Patent(Industrial Property Rights) (17 results) (of which Overseas: 3 results)

  • [Int'l Joint Research] Stockholm University(スウェーデン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] KMITL/NanoTec(タイ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] King Mongkut's Institute of Technology/Ladkrabang(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] King Mongkut's Institute of Technology/Ladkrabang(タイ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] SciLifeLab(スウェーデン)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Mechanical Low-Pass Filtering of Cells for Detection of Circulating Tumor Cells in Whole Blood2020

    • Author(s)
      Suzuki Taiki、Kaji Noritada、Yasaki Hirotoshi、Yasui Takao、Baba Yoshinobu
    • Journal Title

      Analytical Chemistry

      Volume: 92 Issue: 3 Pages: 2483-2491

    • DOI

      10.1021/acs.analchem.9b03939

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Water?Organic Cosolvent Effect on Nucleation of Solution-Synthesized ZnO Nanowires2019

    • Author(s)
      Akihiro Yuya、Nagashima Kazuki、Hosomi Takuro、Kanai Masaki、Anzai Hiroshi、Takahashi Tsunaki、Zhang Guozhu、Yasui Takao、Baba Yoshinobu、Yanagida Takeshi
    • Journal Title

      ACS Omega

      Volume: 4 Issue: 5 Pages: 8299-8304

    • DOI

      10.1021/acsomega.9b00945

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Micro- and Nanopillar Chips for Continuous Separation of Extracellular Vesicles2019

    • Author(s)
      Hattori Yuya、Shimada Taisuke、Yasui Takao、Kaji Noritada、Baba Yoshinobu
    • Journal Title

      Analytical Chemistry

      Volume: 91 Issue: 10 Pages: 6514-6521

    • DOI

      10.1021/acs.analchem.8b05538

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Substantial Narrowing on the Width of “Concentration Window” of Hydrothermal ZnO Nanowires via Ammonia Addition2019

    • Author(s)
      Sakai Daiki、Nagashima Kazuki、Yoshida Hideto、Kanai Masaki、He Yong、Zhang Guozhu、Zhao Xixi、Takahashi Tsunaki、Yasui Takao、Hosomi Takuro、Uchida Yuki、Takeda Seiji、Baba Yoshinobu、Yanagida Takeshi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 14160-14160

    • DOI

      10.1038/s41598-019-50641-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microfluidic Mechanotyping of a Single Cell with Two Consecutive Constrictions of Different Sizes and an Electrical Detection System2019

    • Author(s)
      Sano Mamiko、Kaji Noritada、Rowat Amy C.、Yasaki Hirotoshi、Shao Long、Odaka Hidefumi、Yasui Takao、Higashiyama Tetsuya、Baba Yoshinobu
    • Journal Title

      Analytical Chemistry

      Volume: 91 Issue: 20 Pages: 12890-12899

    • DOI

      10.1021/acs.analchem.9b02818

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rational Method of Monitoring Molecular Transformations on Metal-Oxide Nanowire Surfaces2019

    • Author(s)
      C. Wang, T. Hosomi, K. Nagashima, T. Takahashi, G. Zhang, M. Kanai, H. Zeng, W. Mizukami, N. Shioya, T. Shimoaka, Y. Aoki, J. Terao, T. Hasegawa and T. Yanagida
    • Journal Title

      Nano Lett.

      Volume: 19 Issue: 4 Pages: 2443-2449

    • DOI

      10.1021/acs.nanolett.8b05180

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis of Monodispersedly Sized ZnO Nanowires from Randomly Sized Seeds2019

    • Author(s)
      Zhao Xixi、Nagashima Kazuki、Zhang Guozhu、Hosomi Takuro、Yoshida Hideto、Akihiro Yuya、Kanai Masaki、Mizukami Wataru、Zhu Zetao、Takahashi Tsunaki、Suzuki Masaru、Samransuksamer Benjarong、Meng Gang、Yasui Takao、Aoki Yuriko、Baba Yoshinobu、Yanagida Takeshi
    • Journal Title

      Nano Letters

      Volume: 20 Issue: 1 Pages: 599-605

    • DOI

      10.1021/acs.nanolett.9b04367

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Engineering Nanowire-Mediated Cell Lysis for Microbial Cell Identification2019

    • Author(s)
      Yasui Takao、Yanagida Takeshi、Shimada Taisuke、Otsuka Kohei、Takeuchi Masaki、Nagashima Kazuki、Rahong Sakon、Naito Toyohiro、Takeshita Daiki、Yonese Akihiro、Magofuku Ryo、Zhu Zetao、Kaji Noritada、Kanai Masaki、Kawai Tomoji、Baba Yoshinobu
    • Journal Title

      ACS Nano

      Volume: 13 Pages: 2262-2273

    • DOI

      10.1021/acsnano.8b08959

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PM<sub>2.5</sub> Particle Detection in a Microfluidic Device by Using Ionic Current Sensing2018

    • Author(s)
      SHIMADA Taisuke、YASAKI Hirotoshi、YASUI Takao、YANAGIDA Takeshi、KAJI Noritada、KANAI Masaki、NAGASHIMA Kazuki、KAWAI Tomoji、BABA Yoshinobu
    • Journal Title

      Analytical Sciences

      Volume: 34 Issue: 12 Pages: 1347-1349

    • DOI

      10.2116/analsci.18C018

    • NAID

      130007528641

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2018-12-10
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A real-time simultaneous measurement on a microfluidic device for individual bacteria discrimination2018

    • Author(s)
      H. Yasaki, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai and Y. Baba
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 260 Pages: 746-752

    • DOI

      10.1016/j.snb.2018.01.079

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biomolecular recognition on nanowire surfaces modified by the self-assembled monolayer2018

    • Author(s)
      Shimada Taisuke、Yasui Takao、Yokoyama Asami、Goda Tatsuro、Hara Mitsuo、Yanagida Takeshi、Kaji Noritada、Kanai Masaki、Nagashima Kazuki、Miyahara Yuji、Kawai Tomoji、Baba Yoshinobu
    • Journal Title

      Lab on a Chip

      Volume: 18 Issue: 21 Pages: 3225-3229

    • DOI

      10.1039/c8lc00438b

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Robust Ionic Current Sensor for Bacterial Cell Size Detection2018

    • Author(s)
      H. Yasaki, T. Shimada, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai and Y. Baba
    • Journal Title

      ACS Sensors

      Volume: 3 Issue: 3 Pages: 574-579

    • DOI

      10.1021/acssensors.8b00045

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Channel Geometry on Ionic Current Signal of Bridge Circuit Based Microfluidic Channel2018

    • Author(s)
      H. Yasaki, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai and Y. Baba
    • Journal Title

      Chemistry Letters

      Volume: 47 Issue: 3 Pages: 350-353

    • DOI

      10.1246/cl.171139

    • NAID

      130006434191

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Substantial Expansion of Detectable Size Range in Ionic Current Sensing through Pores by Using a Microfluidic Bridge Circuit2017

    • Author(s)
      Yasaki Hirotoshi、Yasui Takao、Yanagida Takeshi、Kaji Noritada、Kanai Masaki、Nagashima Kazuki、Kawai Tomoji、Baba Yoshinobu
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 139 Issue: 40 Pages: 14137-14142

    • DOI

      10.1021/jacs.7b06440

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Urinary microRNA ensemble biomarkers for medical checkups2020

    • Author(s)
      Takao Yasui
    • Organizer
      The 23rd SANKEN International Symposium -The 18th SANKEN Nanotechnology International Symposium- “Scientific and Industrial Research for Space Age”
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 尿中microRNAのアンサンブルマーカーによる疾病検出2020

    • Author(s)
      安井隆雄
    • Organizer
      第67回応用物理学会春季学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Nanowires meet microarray and AI for urine liquid biopsy2019

    • Author(s)
      Takao Yasui
    • Organizer
      Nanowire week 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノワイヤチップによる尿中microRNAの抽出と機械学習解析によるがん診断2019

    • Author(s)
      安井隆雄
    • Organizer
      JASIS PAI-NET マーケットトレンドセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 尿中microRNA解析によるがん診断2019

    • Author(s)
      安井隆雄
    • Organizer
      大阪大学ナノ理工学人材育成産学コンソーシアム 令和元年度 第2回ナノ理工学情報交流会 「人生100年時代に求められるヘルステック」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ナノ空間制御と尿中microRNAの網羅的解析2019

    • Author(s)
      安井隆雄
    • Organizer
      2019年度第2回バイオ単分子研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] pMAIRS 法による生体関連物質吸着の配向/無配向分析とその応用2019

    • Author(s)
      安井隆雄
    • Organizer
      第4回MAIRSワークショップ
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ナノデバイスとリキッドバイオプシー2019

    • Author(s)
      安井隆雄
    • Organizer
      KISTEC教育講座
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 尿中マイクロRNAの機械学習解析によるがん診断2019

    • Author(s)
      安井隆雄
    • Organizer
      PMEワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ナノ空間制御による生体分子解析2018

    • Author(s)
      安井隆雄
    • Organizer
      SCE2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ナノ空間制御による尿を使った肺がん診断法の創出2018

    • Author(s)
      安井隆雄
    • Organizer
      第4回四国オープンイノベーションワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 医療応用を志向したナノデバイスの創製2018

    • Author(s)
      安井隆雄
    • Organizer
      東北大学セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ナノデバイスによる尿中の細胞外小胞体の分離手法開発とmicroRNA解析2018

    • Author(s)
      安井隆雄
    • Organizer
      「体液中マイクロRNA測定技術基盤開発」第7回ユーザーフォーラム報告会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ナノワイヤのバイオ・医療応用2018

    • Author(s)
      安井隆雄
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ナノ空間制御とバイオ分析法2017

    • Author(s)
      安井隆雄
    • Organizer
      SCE2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ナノ構造特有の新規分離・検出原理発見と高性能生体分子解析2017

    • Author(s)
      安井隆雄
    • Organizer
      日本分析化学会第66年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Oxide nanowires for bio-applications from molecular to cellular levels2017

    • Author(s)
      T. Yasui
    • Organizer
      ICAPMA2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 尿中マイクロRNAから「がん」を特定2018

    • Author(s)
      安井隆雄,馬場嘉信
    • Total Pages
      5
    • Publisher
      株式会社蕗書房
    • Related Report
      2018 Annual Research Report
  • [Book] 酸化物ナノワイヤを用いた非侵襲がん診断技術の創製2018

    • Author(s)
      安井隆雄
    • Total Pages
      2
    • Publisher
      新東工業株式会社
    • Related Report
      2018 Annual Research Report
  • [Book] 尿1mL中のマイクロRNAから、がんの有無特定2018

    • Author(s)
      安井隆雄
    • Total Pages
      5
    • Publisher
      加工技術研究会
    • Related Report
      2018 Annual Research Report
  • [Book] Using zinc oxide nanowires to identify cancer from microRNA found in 1 mL of urine2018

    • Author(s)
      Takao Yasui
    • Total Pages
      6
    • Publisher
      Converting Technical Institute
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞の機能を変化させる方法2020

    • Inventor(s)
      安井隆雄, 馬場嘉信, 夏目敦至
    • Industrial Property Rights Holder
      安井隆雄, 馬場嘉信, 夏目敦至
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-036925
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体分子を分離するための流体デバイス及び方法2019

    • Inventor(s)
      安井隆雄, 馬場嘉信
    • Industrial Property Rights Holder
      安井隆雄, 馬場嘉信
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-125884
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] マイクロRNAを含む体液抽出物2019

    • Inventor(s)
      安井隆雄, 馬場嘉信, 市川裕樹
    • Industrial Property Rights Holder
      安井隆雄, 馬場嘉信, 市川裕樹
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-193847
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞外小胞体分離用デバイス、およびその作動方法2019

    • Inventor(s)
      安井隆雄, 馬場嘉信
    • Industrial Property Rights Holder
      安井隆雄, 馬場嘉信
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 脳腫瘍を検査する方法2019

    • Inventor(s)
      安井隆雄, 馬場嘉信, 夏目敦至
    • Industrial Property Rights Holder
      安井隆雄, 馬場嘉信, 夏目敦至
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-177615
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] miRNAの抽出方法、および、miRNAの解析方法2019

    • Inventor(s)
      安井隆雄, 馬場嘉信
    • Industrial Property Rights Holder
      安井隆雄, 馬場嘉信
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 細胞外小胞を捕捉するために用いられるデバイス、細胞外小胞の保存方法および移送方法2019

    • Inventor(s)
      安井隆雄, 馬場嘉信, 古賀大尚
    • Industrial Property Rights Holder
      安井隆雄, 馬場嘉信, 古賀大尚
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] サンプル分離方法およびサンプル分離用デバイス2019

    • Inventor(s)
      加地範匡, 安井隆雄, 馬場嘉信
    • Industrial Property Rights Holder
      加地範匡, 安井隆雄, 馬場嘉信
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-239849
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 分析用デバイス2019

    • Inventor(s)
      安井隆雄, 馬場嘉信
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-049067
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] デバイスの製造方法、および、デバイス2019

    • Inventor(s)
      安井隆雄, 馬場嘉信, 池田宗和, 新井正雄
    • Industrial Property Rights Holder
      名古屋大学, 東レエンジニアリング株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-048933
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞外小胞体を捕捉するために用いられるデバイス2019

    • Inventor(s)
      安井隆雄, 馬場嘉信, 古賀大尚
    • Industrial Property Rights Holder
      名古屋大学, 大阪大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-036490
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 分析用デバイスの製造方法、分析方法、および、分析用デバイス2019

    • Inventor(s)
      安井隆雄, 馬場嘉信
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-036489
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] マイクロRNAを含む体液抽出物2018

    • Inventor(s)
      安井隆雄, 馬場嘉信, 竹下大貴
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-248924
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] サンプル中の元素の質量分析方法、該質量分析方法に用いる分析用デバイス、および、サンプル捕捉用キット2018

    • Inventor(s)
      安井隆雄, 馬場嘉信, 青木元秀, 梅村知也
    • Industrial Property Rights Holder
      名古屋大学, 東京薬科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-210123
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] miRNAの抽出方法、および、miRNAの解析方法2018

    • Inventor(s)
      安井隆雄, 馬場嘉信
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-203527
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞外小胞体分離用デバイス、および、細胞外小胞体分離用デバイスの作動方法2018

    • Inventor(s)
      安井隆雄, 馬場嘉信
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-169369
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体分子抽出用チップ、及び生体分子抽出用チップの製造方法2017

    • Inventor(s)
      安井隆雄, 柳田剛, 加地範匡, 川合知二, 馬場嘉信
    • Industrial Property Rights Holder
      安井隆雄, 柳田剛, 加地範匡, 川合知二, 馬場嘉信
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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