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Construction of human neuron-muscle actuator to evaluate contractility

Research Project

Project/Area Number 17H04805
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Nano/Microsystems
Research InstitutionThe University of Tokyo

Principal Investigator

Morimoto Yuya  東京大学, 大学院情報理工学系研究科, 准教授 (60739233)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2017: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywordsバイオロボティクス / マイクロ加工 / BioMEMS / 組織工学 / バイオエンジニアリング / マイクロ工学 / 創薬モデル
Outline of Final Research Achievements

In this study, we showed that motor neurons and skeletal muscle fibers were connected by culturing the motor neurons on a human skeletal muscle tissue, and the muscle tissue was contractible according to transmitted signals from the motor neurons. In addition, we succeeded in formation of a skeletal muscle tissue actuator capable of muscle contractions with large contraction amount by arranging a pair of skeletal muscle tissues via a joint. This actuator with skeletal muscle tissues can control rotation of the joint according to contractions of each skeletal muscle tissue, and can manipulate objects by moving an arm attached to the joint with the muscle contraction.

Academic Significance and Societal Importance of the Research Achievements

本研究で生みだした技術は、骨格筋組織の収縮運動の体外での再現に有用であり、生物学分野や医学分野での骨格筋組織の理解に貢献可能である。さらに、生体を模擬した運動を体外で実現できるため、運動学やロボティクスの分野でも大きく貢献可能であり、培養組織の新たな応用先を開拓可能な技術であると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (22 results)

All 2020 2019 2018 2017

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (13 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results) Book (3 results)

  • [Journal Article] Biohybrid robot with skeletal muscle tissue covered with a collagen structure for moving in air2020

    • Author(s)
      Yuya Morimoto、Hiroaki Onoe、Shoji Takeuchi
    • Journal Title

      APL Bioengineering

      Volume: 4 Issue: 2 Pages: 026101-026101

    • DOI

      10.1063/1.5127204

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biohybrid device with antagonistic skeletal muscle tissue for measurement of contractile force2019

    • Author(s)
      Morimoto Yuya、Onoe Hiroaki、Takeuchi Shoji
    • Journal Title

      Advanced Robotics

      Volume: 33 Issue: 5 Pages: 208-218

    • DOI

      10.1080/01691864.2019.1567382

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biohybrid robot powered by an antagonistic pair of skeletal muscle tissues2018

    • Author(s)
      Morimoto Yuya、Onoe Hiroaki、Takeuchi Shoji
    • Journal Title

      Science Robotics

      Volume: 3 Issue: 18

    • DOI

      10.1126/scirobotics.aat4440

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional contractile muscle tissue consisting of human skeletal myocyte cell line2018

    • Author(s)
      Shima Ai、Morimoto Yuya、Sweeney H. Lee、Takeuchi Shoji
    • Journal Title

      Experimental Cell Research

      Volume: 370 Issue: 1 Pages: 168-173

    • DOI

      10.1016/j.yexcr.2018.06.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Perfusable and stretchable 3D culture system for skin-equivalent2018

    • Author(s)
      Nobuhito Mori 、Yuya Morimoto 、Shoji Takeuchi
    • Journal Title

      Biofabrication

      Volume: 11 Issue: 1 Pages: 011001-011001

    • DOI

      10.1088/1758-5090/aaed12

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction and Application of Three-Dimensional Cellular Tissues Assembled by Point-, Line-, and Plane-Shaped Cellular Building Blocks2017

    • Author(s)
      森本 雄矢, 竹内 昌治
    • Journal Title

      IEEJ Transactions on Sensors and Micromachines

      Volume: 137 Issue: 10 Pages: 322-327

    • DOI

      10.1541/ieejsmas.137.322

    • NAID

      130006110316

    • ISSN
      1341-8939, 1347-5525
    • Related Report
      2017 Annual Research Report
  • [Presentation] 培養筋組織とデバイスの融合によるバイオマシンの構築2020

    • Author(s)
      森本雄矢
    • Organizer
      令和2年電気学会全国大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 3次元骨格筋-腱組織の構築2019

    • Author(s)
      森本雄矢, 三浦重徳,竹内昌治
    • Organizer
      日本筋学会 第5回学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 次元筋組織とデバイスの融合による筋組織の工学分野への応用2019

    • Author(s)
      森本雄矢、竹内昌治
    • Organizer
      第2回 筋スマート社会実現コンソーシアム 講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] In situ glucose monitoring in 3D-cultured skeletal muscle tissue2019

    • Author(s)
      Yuya Morimoto, Jun Sawayama, Shoji Takeuchi
    • Organizer
      the 32nd MEMS conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 伸展及び灌流可能な3次元皮膚モデル用培養システム2019

    • Author(s)
      森宣人, 森本雄矢, 竹内昌治
    • Organizer
      化学とマイクロ・ナノシステム学会 第37回研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロ流体デバイス技術を応用した機能的な3次元組織構築技術の開発2019

    • Author(s)
      森本雄矢
    • Organizer
      化学とマイクロ・ナノシステム学会 第37回研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Biohybrid device composed of cultured tissue and artificial device2018

    • Author(s)
      Yuya Morimoto
    • Organizer
      24th iCeMS international symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 拮抗筋構造を有するバイオハイブリッドロボットの構築2018

    • Author(s)
      森本雄矢, 尾上弘晃, 竹内昌治
    • Organizer
      第9回 マイクロ・ナノ工学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 関節駆動可能な骨格筋バイオロボットの構築2018

    • Author(s)
      森本雄矢, 尾上弘晃,竹内昌治
    • Organizer
      バイオマイクロシステム研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Transendothelial Electrical Resistance (TEER) Measurement System of 3D Tubular Vascular Channel2018

    • Author(s)
      Nobuhito Mori, Yuya Morimoto, Shoji Takeuchi
    • Organizer
      The 31st IEEE International Conference on Micro Electro Mechanical Systems
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] COLLAGEN SPONGE-LIKE SCAFFOLD FOR A 3D PERFUSABLE VASCULARIZED TISSUE2017

    • Author(s)
      Nobuhito Mori, Yuya Morimoto, and Shoji Takeuchi
    • Organizer
      The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IN VITRO 3D MICROVESSEL CONSTRUCTION BY GROOVED COLLAGEN-GEL SANDWICH2017

    • Author(s)
      Ai Shima, Yuya Morimoto, and Shoji Takeuchi
    • Organizer
      The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 三次元的に培養したヒト骨格筋細胞は自発的な収縮を示す2017

    • Author(s)
      島亜衣, 森本雄矢, 竹内昌治
    • Organizer
      第3回 日本筋学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Book] Chapter 16, Biohybrid Robot Powered by Muscle Tissues (書名: Mechanically Responsive Materials for Soft Robotics)2020

    • Author(s)
      Yuya Morimoto, Shoji Takeuchi
    • Total Pages
      22
    • Publisher
      Wiley
    • ISBN
      3527346201
    • Related Report
      2019 Annual Research Report
  • [Book] 第5章7 身体運動を再現するバイオハイブリッドロボット (書名:骨格筋研究を核とした筋スマート社会)2019

    • Author(s)
      森本雄矢、竹内昌治
    • Total Pages
      8
    • Publisher
      CMCリサーチ
    • ISBN
      9784904482629
    • Related Report
      2019 Annual Research Report
  • [Book] In vitro tissue construction for organ-on-a-chip application (書名: Applications of Microfluidic Systems in Biology and Medicine)2019

    • Author(s)
      Yuya Morimoto, Nobuhito Mori, Shoji Takeuchi
    • Total Pages
      28
    • Publisher
      Springer
    • ISBN
      9811362289
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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