Sensorless measurement of biometric information for enhancing QOL in magnetically levitated ventricular assist device

• Project/Area Number: 17H04909
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Dynamics/Control
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Hijikata Wataru 東京工業大学, 工学院, 准教授 (30618947)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000); Fiscal Year 2019: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000); Fiscal Year 2018: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2017: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: 磁気浮上型補助人工心臓 / 血栓検出 / 心拍同期制御 / 外乱オブザーバ / 補助人工心臓 / 磁気浮上 / センサレス計測 / 生体情報 / 流量制御 / 協調制御 / 人工心臓 / 磁気浮上システム / 血栓 / 血液粘度

Outline of Final Research Achievements

In the field of ventricular assist devices, pump thrombus and control of appropriate flow rate have been issues to be solved. In this study, we have developed a method for detecting the pump thrombus from the phase difference between the current and displacement. Furthermore, we have also developed motor speed control system which can synchronize with the pulsatile of failure heart by using disturbance observer built in the magnetically levitated system.

Academic Significance and Societal Importance of the Research Achievements

本研究は，人工心臓装着患者の生存率向上および生活の質（QOL）向上に繋がる．特に，追加のセンサを用いずに制御系の変更のみで実装可能な点で，既存の磁気浮上型補助人工心臓にも適用可能であり，汎用性が高い．更に，磁気浮上システムを用いた生体信号のさんサレス計測という，新しい応用分野の発展にもつながる点で，学術的意義が大きい．

Research Products

• [Journal Article] Detection of thrombosis in a magnetically levitated blood pump by vibrational excitation of the impeller (2020)
  • Author(s): Hijikata Wataru、Maruyama Takuro、Murashige Tomotaka、Sakota Daisuke、Maruyama Osamu
  • Journal Title: Artificial Organs Volume: - Issue: 6 Pages: 594-603
  • DOI: 10.1111/aor.13632
  • Peer Reviewed
• [Journal Article] Mechanical antithrombogenic properties by vibrational excitation of the impeller in a magnetically levitated centrifugal blood pump (2019)
  • Author(s): Murashige Tomotaka、Hijikata Wataru
  • Journal Title: Artificial Organs Volume: 43 Issue: 9 Pages: 849-859
  • DOI: 10.1111/aor.13541
  • Peer Reviewed
• [Journal Article] Sensorless measurement of biological information in a magnetically levitated artificial heart and its application to QOL improvement technology (2019)
  • Author(s): Hijikata Wataru
  • Journal Title: Impact Volume: 2019 Issue: 10 Pages: 70-72
  • DOI: 10.21820/23987073.2019.10.70
  • Open Access
• [Journal Article] Measuring real-time blood viscosity with a ventricular assist device (2019)
  • Author(s): Hijikata Wataru、Maruyama Takuro、Suzumori Yuki、Shinshi Tadahiko
  • Journal Title: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine Volume: 233 Issue: 5 Pages: 562-569
  • DOI: 10.1177/0954411919838738
  • Peer Reviewed / Open Access
• [Presentation] 磁気浮上型遠心ポンプの血栓検出手法の急性動物実験による検証 (2020)
  • Author(s): 藤原立樹, 土方亘, 村重智崇, 関晴永, 田原禎生, 横田幸恵, 尾形麻斗, 大内克洋, 荒井裕国
  • Organizer: 第４８回人工心臓と補助循環懇話会学術集会
• [Presentation] 遠心ポンプ内の意図した箇所に血栓形成を誘発させるフィブリノゲンコーティング法の開発 (2020)
  • Author(s): 関晴永, 藤原立樹, 土方亘, 村重智崇, 横田幸恵, 尾形麻斗, 大内克洋, 荒井祐国
  • Organizer: 第４８回人工心臓と補助循環懇話会学術集会
• [Presentation] 磁気浮上インペラの微小加振によって血栓を予防するインテリジェント人工心臓の開発 (2020)
  • Author(s): 土方亘, 村重智崇
  • Organizer: 第４８回人工心臓と補助循環懇話会学術集会
• [Presentation] Evaluating Plasma Skimming with Whole Blood in Small Gap Region Imitating Clearance of Blood Pumps (2019)
  • Author(s): Ming Jiang, Tomotaka Murashige, Daisuke Sakota, Wataru Hijikata
  • Organizer: IEEE EMBC 2019
• [Presentation] 磁気浮上型遠心ポンプの血栓検出に関する研究 (2019)
  • Author(s): 藤原立樹, 土方亘, 大内克洋, 村重智崇, 関春永, 田原禎生, 横田幸恵, 尾形麻斗, 荒井裕国
  • Organizer: 第47回人工心臓と補助循環懇話会学術集会
• [Presentation] 急性動物実験において血液ポンプ内の意図した部位に血栓形成を誘発させる手法の開発 (2019)
  • Author(s): 尾形麻斗, 藤原立樹, 大内 克洋, 土方 亘, 村重 智崇, 佐藤翔太, 関晴永, 荒井裕国
  • Organizer: 第47回人工心臓と補助循環懇話会学術集会
• [Presentation] 知能化磁気浮上システムの開発と医療応用 (2019)
  • Author(s): 土方亘, 村重智崇, 丸山拓朗, 藤原立樹, 大内克洋, 荒井裕国
  • Organizer: 第16回「運動と振動の制御」シンポジウム (MoViC2019)
• [Presentation] Development of an intelligent blood pump with a self-detecting function of thrombus (2018)
  • Author(s): Wataru Hijikata, Tomotaka Murashige, Takuro Maruyama, Asato Ogata, Tatsuki Fujiwara, Katsuhiro Ohuchi, Hirokuni Arai
  • Organizer: 26th Annual Meeting for the International Society for Mechanical Circulatory Support (ISMCS2018)
  • Int'l Joint Research
• [Presentation] Design of an axial blood pump with a large-gap passive levitation technology utilizing a combination of magnetic force and thrust force (2018)
  • Author(s): Kazuma Shoji, Tomotaka Murashige, Wataru Hijikata
  • Organizer: 26th Annual Meeting for the International Society for Mechanical Circulatory Support (ISMCS2018)
  • Int'l Joint Research
• [Presentation] Reduction of von Willebrand factor in response to shear stress loading and evaluation of bleeding risk prior to LVAD implantation (2018)
  • Author(s): Ko Sakatsume, Masatoshi Akiyama, Yunan Zuo, Daisuke Sakota, Wataru Hijikata, Hisanori Horiuchi, Osamu Maruyama, Yoshikatsu Saiki
  • Organizer: 26th Annual Meeting for the International Society for Mechanical Circulatory Support (ISMCS2018)
  • Int'l Joint Research
• [Presentation] Prevention of thrombus formation inside a magnetically levitated centrifugal blood pump using impeller vibration excitation (2018)
  • Author(s): Tomotaka Murashige, Ming Jiang, Wataru Hijikata
  • Organizer: 26th Annual Meeting for the International Society for Mechanical Circulatory Support (ISMCS2018)
  • Int'l Joint Research
• [Presentation] Effect of impeller vibrational excitation on enhancing antithrombogenic properties of a centrifugal blood pump with a magnetic bearing (2018)
  • Author(s): Tomotaka Murashige, Wataru Hijikata
  • Organizer: 45th Annual European Society for Artificial Organs,The International Journal of Artificial Organs
  • Int'l Joint Research
• [Presentation] Development of an intelligent ventricular assist device with a function of sensorless thrombus detection (2018)
  • Author(s): Takuro Maruyama, Tomotaka Murashige, Daisuke Sakota, Osamu Maruyama, Wataru Hijikata
  • Organizer: Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2018
  • Int'l Joint Research
• [Presentation] 均一なshear stress負荷によるvon Willebrand因子高分子多量体の減少と出欠リスクの評価 (2018)
  • Author(s): 坂爪公, 秋山正年, 左雨南, 迫田大輔, 土方亘, 堀内久徳, 丸山修, 齊木佳克
  • Organizer: 第５６回日本人工臓器学会大会
• [Presentation] センサレス血栓検知機能を備えたインテリジェント人工心臓の開発 (2018)
  • Author(s): 丸山拓朗, 村重智崇, 土方亘
  • Organizer: 生活生命支援医療福祉工学系連合大会(LIFE2018)
• [Presentation] ポンプ内血栓を自己検知するインテリジェント人工心臓の開発 (2018)
  • Author(s): 村重智崇, 丸山拓朗, 迫田大輔, 丸山修, 土方亘
  • Organizer: 第４６回人工心臓と補助循環懇話会学術集会
• [Presentation] Sensorless Detection of Thrombus Using Real-Time Viscosity Measurement in a Magnetically-Levitated Rotary Blood Pump (2017)
  • Author(s): Takuro Maruyama, Tomotaka Murashige, Daisuke Sakota, Osamu Maruyama, Wataru Hijikata
  • Organizer: International Society for Mechanical Circulatory Support 2017
  • Int'l Joint Research
• [Presentation] 人工心臓用磁気軸受を用いたセンサレス血栓検出の研究 (2017)
  • Author(s): 丸山拓朗, 迫田大輔, 丸山修, 土方亘
  • Organizer: 第２９回「電磁力関連のダイナミクス」シンポジウム
• [Presentation] 磁気浮上式人工心臓におけるセンサレス粘度推定とその応用 (2017)
  • Author(s): 丸山 拓朗, 土方 亘, 進士 忠彦
  • Organizer: 日本機械学会関東学生会第56回学生員卒業研究発表講演会
• [Remarks] 東京工業大学リサーチリポジトリ
  • URL: http://t2r2.star.titech.ac.jp/cgi-bin/researcherpublicationlist.cgi?q_researcher_content_number=CTT100514739&alldisp=1&tab_yf=2019
• [Remarks] T2R2 Tokyo Tech Research Repository
  • URL: http://t2r2.star.titech.ac.jp/cgi-bin/researcherpublicationlist.cgi?q_researcher_content_number=CTT100514739
• [Remarks] 東京工業大学 岡田土方研究室 土方グループ 研究内容
  • URL: http://www.hcds.esd.titech.ac.jp/htmls/hijikata-group/research.html