Development of microdosimetric imaging technology for targeted radionuclide therapy

• Project/Area Number: 17H05093
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Kodaira Satoshi 国立研究開発法人量子科学技術研究開発機構, 高度被ばく医療センター 計測・線量評価部, 研究統括(定常) (00434324)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000); Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 標的アイソトープ治療 / アルファ線 / オージェ電子 / 固体飛跡検出器 / 線量評価 / 線量分布 / イメージング / マイクロドシメトリ / 線量計測 / アスタチン / α線 / 線量分布イメージング

Outline of Final Research Achievements

The targeted radionuclide therapy (TRT) with α-particle and auger electron emitters is expected as the efficient treatments for metastatic cancer because the former provides a high linear energy transfer (LET) to induce enough damage to break double-stranded DNA and it has a short range in tissue to target only cancer cells without additional damage to surrounding normal cells. The physical aspects related to dosimetry should be addressed for characterizing the treatment effectiveness by α-particles and auger electrons and for optimizing the treatment conditions such as injection amount and concentration. We have established microdosimetric imaging technology of local dose distribution in the targeted cells and tissues for the advances in TRT.

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた成果は、標的アイソトープ治療において現状では評価できていない単一細胞レベルでの線量評価が可能な唯一の計測技術である。治療効果の検証や放射性薬剤の品質評価だけでなく、副作用の要因となる正常組織における被ばく影響の両面において、定量的な線量評価が可能となる。臨床に向けた治療計画や放射線防護の観点から、投与線量の不均一性を考慮した線量評価の必要性を初めて提示することができた。標的アイソトープ治療は計画的内部被ばくの側面があり、医療被ばく防護に資する研究も重要である。本研究成果を通じて、安心・安全で効果的な標的アイソトープ治療の進展に貢献できると考えている。

Research Products

• [Int'l Joint Research] Landauer Inc.(米国)
• [Int'l Joint Research] Landauer Inc.(米国)
• [Journal Article] Utility of 211At-trastuzumab for the Treatment of Metastatic Gastric Cancer in the Liver: Evaluation of a Preclinical α-Radioimmunotherapy Approach in a Clinically-relevant Mouse Model (2021)
  • Author(s): Li Huizi Keiko、Morokoshi Yukie、Kodaira Satoshi、Kusumoto Tamon、Minegishi Katsuyuki、Kanda Hiroaki、Nagatsu Kotaro、HASEGAWA SUMITAKA
  • Journal Title: Journal of Nuclear Medicine Volume: in press Issue: 10 Pages: 1468-1474
  • DOI: 10.2967/jnumed.120.249300
  • Peer Reviewed
• [Journal Article] 放射線の蛍光飛跡検出技術と応用研究 (2021)
  • Author(s): 小平聡, 楠本多聞
  • Journal Title: 日本写真学会誌 Volume: 84 Pages: 22-27
  • Peer Reviewed
• [Journal Article] Characteristics of fluorescent nuclear track detection with Ag+-activated phosphate glass (2020)
  • Author(s): Kodaira Satoshi、Kusumoto Tamon、Kitamura Hisashi、Yanagida Yuka、Koguchi Yasuhiro
  • Journal Title: Radiation Measurements Volume: 132 Pages: 106252-106252
  • DOI: 10.1016/j.radmeas.2020.106252
  • Peer Reviewed
• [Journal Article] Verification of dose estimation of Auger electrons emitted from Cu-64 using a combination of FNTD measurements and Monte Carlo simulations (2020)
  • Author(s): Kusumoto Tamon、Matsuya Yusuke、Baba Kentaro、Ogawara Ryo、Akselrod Mark S.、Harrison Jonathan、Fomenko Vasiliy、Kai Takeshi、Ishikawa Masayori、Hasegawa Sumitaka、Kodaira Satoshi
  • Journal Title: Radiation Measurements Volume: 132 Pages: 106256-106256
  • DOI: 10.1016/j.radmeas.2020.106256
  • Peer Reviewed
• [Journal Article] Evidence of Local Concentration of α-Particles from 211At-Labeled Antibodies in Liver Metastasis Tissue (2018)
  • Author(s): Kodaira Satoshi、Morokoshi Yukie、Li Huizi Keiko、Konishi Teruaki、Kurano Mieko、Hasegawa Sumitaka
  • Journal Title: Journal of Nuclear Medicine Volume: 60 Issue: 4 Pages: 497-501
  • DOI: 10.2967/jnumed.118.216853
  • Peer Reviewed / Open Access
• [Presentation] Single cellular dosimetry with ion track detection technology (2020)
  • Author(s): S. Kodaira, T. Kusumoto, T. Konishi
  • Organizer: IAEA Technical Meeting on Imaging Using Ionizing Radiation to Address Biological Challenges, Nov. 30-Dec. 3, 2020 (Online meeting)
  • Int'l Joint Research
• [Presentation] Characteristics of fluorescence nuclear track detection with Ag+-activated phosphate glass (2019)
  • Author(s): Satoshi Kodaira, Tamon Kusumoto, Hisashi Kitamura, Yuka Yanagida, Yasuhiro Koguchi
  • Organizer: 19th International Conference on Solid State Dosimetry
  • Int'l Joint Research
• [Presentation] 固体飛跡検出器を用いた標的アイソトープ治療に資する局所線量分布イメージング (2019)
  • Author(s): 小平 聡, 楠本 多聞, 蔵野 美恵子, 北村 尚, 小西 輝昭, 諸越 幸恵, 李 惠子, 長谷川 純崇
  • Organizer: 第33回固体飛跡検出器研究会
• [Presentation] 64Cu-ATSMを用いた内用療法に資するFNTDを用いた線量評価法の確立 (2019)
  • Author(s): 楠本 多聞, 長谷川 純崇, 小西 輝昭, 小川原 亮, 蔵野 美恵子, 北村 尚, 小平 聡
  • Organizer: 第33回固体飛跡検出器研究会
• [Presentation] イオントラックを用いた線量計測技術とその応用 (2017)
  • Author(s): 小平聡
  • Organizer: 第60回放射線化学討論会
  • Invited
• [Presentation] Radiation dosimetry of α-particle emission from 211At-labeled antibodies in single cells for cancer radioimmunotherapy using CR-39 plastic nuclear track detectors (2017)
  • Author(s): Satoshi Kodaira, Huizi Keiko Li, Teruaki Konishi, Hisashi Kitamura, Mieko Kurano, Sumitaka Hasegawa
  • Organizer: 27th International Conference on Nuclear Tracks and Radiation Measurements
  • Int'l Joint Research