Challenges for neutron imaging toward low-dose particle therapy
Project/Area Number |
17H06298
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Research Category |
Grant-in-Aid for Challenging Research (Pioneering)
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Allocation Type | Single-year Grants |
Research Field |
Biomedical engineering and related fields
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Research Institution | Waseda University |
Principal Investigator |
Kataoka Jun 早稲田大学, 理工学術院, 教授 (90334507)
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Project Period (FY) |
2017-06-30 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2017: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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Keywords | 中性子イメージング / 粒子線治療 / 2次被ばく / TOF弁別 / PSD弁別 / Time-of-Flight / Time of Flight |
Outline of Final Research Achievements |
The problem of "secondary exposure" is becoming more serious in proton beam therapy for cancer treatment. The proton beam reacts with the metal collimator when it is focused, and it also produces a large amount of fast neutrons in the patient's body. These incidental doses cannot be accurately evaluated by the current treatment system and cannot be reflected in the treatment plan. In this research, we developed an innovative imaging method for fast neutrons, and succeeded in imaging with a proton beam that mimic the actual treatment site. Specifically, we fabricated an array type detector consisting of two layers of waveform discrimination type plastic scintillator, and estimated the neutron arrival direction from the kinematics of elastic scattering. We tried to estimate the dose equivalent using the G(E) function method from the acquired neutron images. We conclude that about 1/100 of the the primary proton dose is given by fast neutrons during the proton therapy.
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Academic Significance and Societal Importance of the Research Achievements |
陽子線治療は先進医療の代表であり、抗がん剤や手術よりQOL(Quality of Life)が高く社会復帰の早い治療法として近年ますます需要が高まっている。一方で、放射線治療はその性質上、正確な線量評価が不可欠である。本研究で開発した中性子可視化技術は「2次被ばく」の評価を初めて可能にし、今後の高精度治療へ向けた大きな足掛かりとなる。さらに、次世代治療として注目を集めるホウ素中性子捕獲療法(BNCT)、原発内部のエリアモニタやテロ対策に至るまで、多くの分野で迅速に中性子場を可視化するカメラの開発が切望されており、本研究の技術が確実に生かされると期待される。
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Development of novel neutron camera to estimate secondary particle dose for safe proton therapy2019
Author(s)
Tagawa,L.; Kataoka,J. Sueoka,K., Fujieda.K.; Kurihara,T., Arimoto,M.; Mochizuki,S.; Maruhashi,T.; Toshito,T., Kimura,M., Inaniwa.T.
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Journal Title
Nuclear Inst. and Methods in Physics Research, A
Volume: 936
Pages: 31-33
DOI
Related Report
Peer Reviewed
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[Journal Article] Development of novel neutron camera to estimate secondary particle dose for safe proton therapy2019
Author(s)
Tagawa,L.; Kataoka,J.; Sueoka,K.; Fujieda,K.; Kurihara,T.; Arimoto,M.; Mochizuki,S.; Maruhashi,T.; Toshito,T.; Kimura,M.; Inaniwa,T.
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Journal Title
Nuclear Inst. and Meth. Section A
Volume: 未定
Pages: 31-33
DOI
Related Report
Peer Reviewed
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[Presentation] Development of novel neutron camera to estimate secondary particle dose for safe proton therapy2018
Author(s)
Tagawa,L.; Kataoka,J.; Sueoka,K.; Fujieda,K.; Kurihara,T.; Arimoto,M.; Mochizuki,S.; Maruhashi,T.; Toshito,T.; Kimura,M.; Inaniwa,T.
Organizer
IEEE MIC/NSS
Related Report
Int'l Joint Research
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[Presentation] Development of new compact neutron camera for safe proton therapy2018
Author(s)
Tagawa,L.; Kataoka,J.; Sueoka,K.; Fujieda,K.; Kurihara,T.; Arimoto,M.; Mochizuki,S.; Maruhashi,T.; Toshito,T.; Kimura,M.; Inaniwa,T.
Organizer
14th PISA meeting
Related Report
Int'l Joint Research
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[Presentation] 粒子線治療下でのイメージングに向けた中性子カメラの開発2018
Author(s)
田川怜央, 片岡淳, 末岡晃紀, 藤枝和也 , 栗原拓也 , 有元誠, 望月早駆, 丸橋拓也, 歳藤利行, 木村充宏, 稲庭拓
Organizer
第 65 回応用物理学会春季学術講演会
Related Report
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