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Challenges for neutron imaging toward low-dose particle therapy

Research Project

Project/Area Number 17H06298
Research Category

Grant-in-Aid for Challenging Research (Pioneering)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering and related fields
Research InstitutionWaseda University

Principal Investigator

Kataoka Jun  早稲田大学, 理工学術院, 教授 (90334507)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2017: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Keywords中性子イメージング / 粒子線治療 / 2次被ばく / TOF弁別 / PSD弁別 / Time-of-Flight / Time of Flight
Outline of Final Research Achievements

The problem of "secondary exposure" is becoming more serious in proton beam therapy for cancer treatment. The proton beam reacts with the metal collimator when it is focused, and it also produces a large amount of fast neutrons in the patient's body. These incidental doses cannot be accurately evaluated by the current treatment system and cannot be reflected in the treatment plan. In this research, we developed an innovative imaging method for fast neutrons, and succeeded in imaging with a proton beam that mimic the actual treatment site. Specifically, we fabricated an array type detector consisting of two layers of waveform discrimination type plastic scintillator, and estimated the neutron arrival direction from the kinematics of elastic scattering. We tried to estimate the dose equivalent using the G(E) function method from the acquired neutron images. We conclude that about 1/100 of the the primary proton dose is given by fast neutrons during the proton therapy.

Academic Significance and Societal Importance of the Research Achievements

陽子線治療は先進医療の代表であり、抗がん剤や手術よりQOL(Quality of Life)が高く社会復帰の早い治療法として近年ますます需要が高まっている。一方で、放射線治療はその性質上、正確な線量評価が不可欠である。本研究で開発した中性子可視化技術は「2次被ばく」の評価を初めて可能にし、今後の高精度治療へ向けた大きな足掛かりとなる。さらに、次世代治療として注目を集めるホウ素中性子捕獲療法(BNCT)、原発内部のエリアモニタやテロ対策に至るまで、多くの分野で迅速に中性子場を可視化するカメラの開発が切望されており、本研究の技術が確実に生かされると期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (11 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Development of a neutron camera to visualize direction and dose of secondary neutrons in real-time for proton therapy2020

    • Author(s)
      Tanaka,R.; Kataoka,J.; Tagawa,L.; Fujieda,K.; Sato,S.; Nishi,F.; Inaniwa.T.
    • Journal Title

      IEEE MIC/NSS 2020 conf. series

      Volume: ―

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Development of novel neutron camera to estimate secondary particle dose for safe proton therapy2019

    • Author(s)
      Tagawa,L.; Kataoka,J. Sueoka,K., Fujieda.K.; Kurihara,T., Arimoto,M.; Mochizuki,S.; Maruhashi,T.; Toshito,T., Kimura,M., Inaniwa.T.
    • Journal Title

      Nuclear Inst. and Methods in Physics Research, A

      Volume: 936 Pages: 31-33

    • DOI

      10.1016/j.nima.2018.11.090

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of novel neutron camera to estimate secondary particle dose for safe proton therapy2019

    • Author(s)
      Tagawa,L.; Kataoka,J.; Sueoka,K.; Fujieda,K.; Kurihara,T.; Arimoto,M.; Mochizuki,S.; Maruhashi,T.; Toshito,T.; Kimura,M.; Inaniwa,T.
    • Journal Title

      Nuclear Inst. and Meth. Section A

      Volume: 未定 Pages: 31-33

    • DOI

      10.1016/j.nima.2018.10.090

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 即発ガンマ線を用いた12C-p核反応測定法の提案と実証2020

    • Author(s)
      西 郁也、片岡 淳、田中 稜、細淵 真那、細越 裕希、稲庭 拓
    • Organizer
      第67回応用物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 陽子線治療における二次中性子イメージングカメラの開発2019

    • Author(s)
      田中 稜、片岡 淳、藤枝 和也、佐藤 将吾、西 郁也
    • Organizer
      第80回応用物理学会秋季学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] MeVガンマ線コンプトンカメラの最適化および性能評価2019

    • Author(s)
      細越 裕希、片岡 淳、望月 早駆、米山 昌樹、棚田 和玖、藤枝 和也、伊藤 颯一郎、木地 浩章、西 郁也、宮本 修治
    • Organizer
      第66回応用物理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] チェレンコフ光検出型MeVガンマ線偏光計の提案と実証2019

    • Author(s)
      米山 昌樹、片岡 淳、望月 早駆、伊藤 颯一郎、木地 浩章、西 郁也、細越 裕希、 宮本 修治
    • Organizer
      第66回応用物理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of novel neutron camera to estimate secondary particle dose for safe proton therapy2018

    • Author(s)
      Tagawa,L.; Kataoka,J.; Sueoka,K.; Fujieda,K.; Kurihara,T.; Arimoto,M.; Mochizuki,S.; Maruhashi,T.; Toshito,T.; Kimura,M.; Inaniwa,T.
    • Organizer
      IEEE MIC/NSS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of new compact neutron camera for safe proton therapy2018

    • Author(s)
      Tagawa,L.; Kataoka,J.; Sueoka,K.; Fujieda,K.; Kurihara,T.; Arimoto,M.; Mochizuki,S.; Maruhashi,T.; Toshito,T.; Kimura,M.; Inaniwa,T.
    • Organizer
      14th PISA meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 粒子線治療下でのイメージングに向けた中性子カメラの開発2018

    • Author(s)
      田川怜央, 片岡淳, 末岡晃紀, 藤枝和也 , 栗原拓也 , 有元誠, 望月早駆, 丸橋拓也, 歳藤利行, 木村充宏, 稲庭拓
    • Organizer
      第 65 回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 宇宙から医療まで:放射線イメージングの最前線2018

    • Author(s)
      片岡淳
    • Organizer
      第 65 回応用物理学会春季学術講演会・特別シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited

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Published: 2017-07-21   Modified: 2021-02-19  

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