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Impact of microRNAs in the exosomes secreted from adipocytes on diet-induced prostate cancer development

Research Project

Project/Area Number 17H06535
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionAkita University

Principal Investigator

Nara Taketoshi  秋田大学, 医学部附属病院, 助教 (00801888)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords前立腺癌 / 高脂肪食 / エクソソーム / microRNA
Outline of Final Research Achievements

Here we assessed the impact of microRNAs in the exosomes secreted from adipocytes on diet-induced prostate cancer initiation and development using in vitro model, in vivo model, and human tissues. Our previous models have several limitations such as immune deficient mice, different diet sources, and ectopic models. In this study, we successfully developed two different immunocompetent mouse models of lard diet-induced prostate cancer progression. Moreover, we extracted exosomes from 22Rv-1 prostate cancer cells and human adipose tissues from surgical specimens in cancer patients and confirmed size, concentration and marker expression of these exosomes.

Academic Significance and Societal Importance of the Research Achievements

高脂肪食や肥満は前立腺癌の危険因子といわれている。また、脂肪細胞は過剰に摂取したエネルギー貯蔵庫としての機能だけでなく、エクソソームなどを分泌する内分泌細胞としての機能を有することが明らかとなっている。さらにエクソソーム内のmicroRNAと癌化の関連が様々な癌種で報告されている。本研究では、高脂肪食摂取および肥満下の前立腺癌発症・進展と脂肪組織、エクソソーム、microRNAの関与を検討した。

Report

(3 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (5 results)

All 2020 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Impact of Nuclear YAP1 Expression in Residual Cancer After Neoadjuvant Chemohormonal Therapy With Docetaxel for High-Risk Localized Prostate Cancer2020

    • Author(s)
      Yoshinori Matsuda, Shintaro Narita, Taketoshi Nara, Huang Mingguo, Hiromi Sato, Atsushi Koizumi, Sohei Kanda, Kazuyuki Numakura, Mitsuru Saito, Takamitsu Inoue, Yuko Hiroshima, Hiroshi Nanji, Shigeru Satoh, Norihiko Tsuchiya, Tomonori Habuchi
    • Journal Title

      BMC Cancer

      Volume: 20 Issue: 1 Pages: 2034-2034

    • DOI

      10.1186/s12885-020-06844-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Research Evidence on High-Fat Diet-Induced Prostate Cancer Development and Progression2019

    • Author(s)
      Narita S, Nara T, Sato H, et al.
    • Journal Title

      J Clin Med.

      Volume: 8 Issue: 5 Pages: 597-597

    • DOI

      10.3390/jcm8050597

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] The impact of specific fat diets and obesity on prostate cancer initiation and progression using two differen t immunocompetent mouse models2020

    • Author(s)
      Hiromi Sato , Shintaro Narita , Ryohei Yamamoto , Atsushi Koizumi , Taketoshi Nara , Sohei Kanda , Kazuyuki Numakura Mitsuru Saito , Takamitsu Inoue , Shigeru Satoh , Toshiaki Yosh ioka , Tomonori Habuchi .
    • Organizer
      EAU 2020, vertual.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HFD leads to metabolic modification of prostate cancer promoting stroma by the upregulation of MIC-12019

    • Author(s)
      Huang, M., Narita, S., Koizumi, A., Nara, T., Numakura, K., Satoh, S., Nanjo, H., Habuchi, T.
    • Organizer
      第 78 回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Macrophage inhibitory cytokine-1 stimulates stromal cytokine production in high-fat diet-induced prostate cancer progression.2018

    • Author(s)
      Huang, M., Narita, S., Koizumi, A., Nara, T. ,Kanda, S., Numakura, K., Tsuruta, H., Saito, M.,Inoue, T. and Habuchi, T.
    • Organizer
      The 113th Annual Meeting of the American Urological Association
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2017-08-25   Modified: 2021-02-19  

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