Investigation on vein graft restenosis after lower extremity bypass surgery

• Project/Area Number: 17H06635
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cardiovascular surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Takayama Toshio 東京大学, 医学部附属病院, 講師 (80802694)
• Project Period (FY): 2017-08-25 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 静脈グラフト / 内膜肥厚 / 再狭窄

Outline of Final Research Achievements

Vein graft restenosis is a common problem after lower extremity bypass surgery. Intimal hyperplasia caused by pathological proliferation of arterial smooth muscle cell is supposed to be a major etiology of this problem; however, the actual mechanism of the smooth muscle cell hyperproliferation is still unknown. We planned to investigate on this question by analyzing rat femoral artery bypass model using autovein graft. Although this model requires a high technical skill, we have successfully stabilized the surgical skill at the end of the research term.

Academic Significance and Societal Importance of the Research Achievements

ラット大腿静脈グラフトを用いた大腿動脈バイパスモデルは、静脈グラフトの内膜肥厚を研究するために適した動物実験モデルであるが、微小な血管どうしを顕微鏡下に吻合するという操作を必要とし、その技術的難易度は非常に高い。我々は研究期間終了時までにモデル作成手技の安定化に成功し、次なる段階としての静脈グラフト内膜肥厚機構解明に向けた実験の準備段階を終えることができた。