| Project/Area Number |
17H06660
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IWASAKI Yuko 東京医科歯科大学, 大学院医歯学総合研究科, プロジェクト助教 (10801516)
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| Research Collaborator |
KAWAGISHI Masahiko
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| Project Period (FY) |
2017-08-25 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 悪性リンパ腫 / 炎症 / ラマン散乱光 / 眼科 / 癌 / 診断 / 細胞-組織 / 臨床 |
|---|
| Outline of Final Research Achievements |
We evaluated how effective Raman spectrum analysis at single cell resolution is for distinguishing malignant lymphoma from lymphocyte. The analysis distinguished malignant lymphoma cell from B lymphocyte with mean sensitivity of 94.2% (92.3%～95.1%) and mean specificity of 95.5% (92.3%～96.1%). Furthermore, the analysis distinguished lymphoma cell from activated T lymphocyte with mean sensitivity of 93.8% (91.6%～95.3%) and mean specificity of 73.7% (69.0%～76.9%). Raman spectroscopy at a single cell resolution was effective to diagnose malignant lymphoma cell from lymphocyte.
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| Academic Significance and Societal Importance of the Research Achievements |
ラマン散乱光解析は１細胞レベルの測定で悪性リンパ腫と正常リンパ球を鑑別できることが、初めて示された。このことから、将来、眼内に浸潤した細胞を眼内にあるままで撮影できるようになれば、悪性リンパ腫の診断に有用であることが期待される。本研究により、ラマン散乱光解析の新しい臨床応用方法が提案された。
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