Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Outline of Final Research Achievements |
Primary aldosteronism, which is a the most common form of secondary hypertension, leads to cardiovascular disease and renal dysfunction by excess aldosterone secretion. This study revealed that ER chaperone calmegin (CLGN) was up-regulated in aldosterone producing adenoma and CLGN up-regulated aldosterone synthesis (CYP11B2) by translational regulation. These findings could be useful for the development of agents of targeting aldosterone production.
|