| Project/Area Number |
17H07035
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2017-08-25 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 甲状腺未分化癌 / PD-L1 / 免疫チェックポイント / 免疫治療 / 分子標的治療 / 甲状腺癌 / 未分化 |
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| Outline of Final Research Achievements |
We have investigated the expression of PD-L1 in human anaplastic thyroid cancer (ATC) by immuno-histochemicaly (IHC). The PD-L1 expression ratio in human ATC was higher than that of papillary thyroid cancer, follicular thyroid cancer, and adenomatous goiter.
Second, we evaluate the expression of PD-L1 in ATC human cell lines. Western blotting and IHC showed the over-expression of PD-L1 in ATC human cell lines. Then we have made the xenograft ATC model using these cells. The tissue from xenograft ATC model also showed PD-L1 over-expression.
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| Academic Significance and Societal Importance of the Research Achievements |
甲状腺未分化癌は非常に進行が早く（１年生存率３０％以下）、治療方法が限られた癌種である。我々は本研究を通して甲状腺未分化癌においてPD-L1の過剰発現が見られることを見出した。このPD-L1過剰発現した腫瘍は、PD-1抗体（Nibormabなど）を用いた治療が可能となる可能性がある。甲状腺癌を対象としたPD-1抗体の臨床試験を行う前に、モデルマウスでも効果が見られるかを検証する必要があり、本研究はその前段階のモデルマウスを作成し、PD-L1の過剰発現を確かめた。
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