| Project/Area Number |
17H07091
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
Sano Kokoro 慶應義塾大学, 医学部(信濃町), 特任助教 (40804597)
|
|---|
| Project Period (FY) |
2017-08-25 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 涙液分泌 / 腸内細菌 / 環境 / 動物 / ストレス |
|---|
| Outline of Final Research Achievements |
I considered the association between tear secretion and intestinal bacteria for a new approach to dry-eye disease. I prepared 3 housing environments, normal environment, enriched environment, stress environment, and I gave C57BL/6 mice each environment for observing the change of intestinal bacteria. Moreover I administered antibiotics to mice for observing the change of intestinal bacteria and tear secretion. The difference of environment led to the change of structure of intestinal bacteria. Mice administered antibiotics showed lower tear secretion compared with normal mice.These results showed the difference of housing environment brought the change of structure of intestinal bacteria and suggested the relationship between tear secretion and structure of intestinal bacteria.
|
