Regulation of tissue morphogenesis by mechanosensor channel Piezo1
| Project/Area Number |
17H07332
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
Tanaka Keiko 基礎生物学研究所, 初期発生研究部門, 助教 (70799246)
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| Research Collaborator |
Patapoutian Ardem スクリプス研究所, ドリス神経科学センター, 教授
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| Project Period (FY) |
2017-08-25 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Piezo / 機械的な力 / 組織形態形成 / メカノセンシング / Piezo チャネル |
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| Outline of Final Research Achievements |
It remains obscure how mechanical forces affect phenomena in vivo. I have been focusing on Piezo channels, which were identified as mechanosensor proteins several years ago. I have found that Piezo is required for proper tissue morphogenesis. In this research project, in order to clarify the relationship between Piezo protein and tissue morphology consisting of many cells, I have looked for changes induced by Piezo activation in these cells by immunostaining. I observed changes in the amount and/or localization of proteins for cytoskeleton and cellular adhesion. In addition, I have been setting up systems to detect Piezo activity in vivo and in vitro.
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Report
(2 results)
Research Products
(2 results)
