Simulation study of protein related to myopathy
| Project/Area Number |
17K00418
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
Takasu Masako 東京薬科大学, 生命科学部, 教授 (50202148)
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| Co-Investigator(Kenkyū-buntansha) |
森河 良太 東京薬科大学, 生命科学部, 准教授 (70266899)
宮川 毅 東京薬科大学, 生命科学部, 助教 (40287462)
野口 瑶 東京薬科大学, 生命科学部, 助教 (60848836)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | シミュレーション / タンパク質 / 筋疾患 / FHL1 / 分子動力学法 / アミノ酸 / 分子動力学シミュレーション |
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| Outline of Final Research Achievements |
FHL1 proteins are important for the function and growth of muscle. In our study, with wild type and mutant types (C104Y, H123Y, C150Y, C153Y) of FHL1, we have performed molecular dynamics simulation for the models of LIM2 domain. In the non-bonding model of C104Y and bonding model of C150Y, we found a large structural changes of zinc fingers. Moreover, in the non-bonding model of C150Y, the RMSD of zinc fingers becomes large and the model shows the relative positions of zinc fingers.
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| Academic Significance and Societal Importance of the Research Achievements |
筋疾患はタンパク質のアミノ酸変異と関係しており、特にFHL1遺伝子に変異が見られる場合がある。そのように重要なFHL1に関して、実際に症例が報告されている変異型のタンパク質に関して基礎的なシミュレーションを行うことは意義がある。本計算の結果により、実験研究者や医学の研究者に役立つ可能性がある。またFHL1はzinc fingerを持っており、他の同種のタンパク質の物性研究に役立つ可能性がある。
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Report
(6 results)
Research Products
(17 results)
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[Presentation] Molecular Dynamics Simulation of Proteins Related to Myopathy2021
Author(s)
Motokuni Nakajima, Yoh Noguchi, Hironao Yamada, Ryota Morikawa, Masako Takasu (presenter), Yukiko K. Hayashi
Organizer
Quantum Science Symposium, ICCMSE 2021, 2021.9, Crete, Greece, online.
Related Report
Int'l Joint Research / Invited
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[Presentation] Simulation Study for wild-type and C101F mutant of LIM2 domain in FHL12018
Author(s)
Takeuchi, H., Okajima, H., Yamada, H., Miyakawa, T., Morikawa, R., Takasu, M., Hayashi, K. Y.
Organizer
8th International Conference of Bioscience, Biochemistry and Bioinformatics
Related Report
Int'l Joint Research
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