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Trial to analysis of transgenerational effect for the large Japanese field mice after the Fukushima Daiichi nuclear power plant accident.

Research Project

Project/Area Number 17K00587
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental impact assessment
Research InstitutionHokkaido University of Science (2018-2019)
Hokkaido Pharmaceutical University School of Pharmacy (2017)

Principal Investigator

Nakata Akifumi  北海道科学大学, 薬学部, 准教授 (70415420)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords放射線 / 生殖腺 / 生物影響 / 減数分裂 / 遺伝子発現 / 野生動物 / 生殖細胞 / 染色体 / 環境
Outline of Final Research Achievements

To analyze the effects of radiation on the gonads, we assessed the gonads of the large Japanese field mice with different chromosome numbers considering chromosomal abnormalities (2n=48 type, 2n=46 type, and hybrid (2n=47 type)) and 2n=48 type mice inhabiting radiation in contaminated areas. The reproductive cycle was clarified from the analysis of histological and morphological changes in the testis and ovary of the large Japanese field mice, but it is unclear whether the reproductive cycle is affected by radiation. On the other hand, we applied gene expression analysis using microarrays to the evaluation of the gonads of laboratory mice exposed to acute and chronic low-dose γ-ray irradiation. Gene expression profiling showed that genes associated with fertilization are changed.

Academic Significance and Societal Importance of the Research Achievements

放射性物質汚染地域に生息するアカネズミは慢性的な被ばくを受けているため、継世代的影響を考える上で有用なモデルである。しかしながら、アカネズミの生殖機能に関するする知見はほぼ蓄積されていないため、放射線影響評価が困難となっている。実験動物における生殖技術を基盤とした手法をアカネズミに適用し、ラボマウスと比較することで、ラボとフィールドの違いを検証が可能となると考えている。野生動物における放射線の影響評価系の構築が可能となった場合、生態系に対する影響、環境保全の手助けとなり、被災住民の帰還の判断材料となることが期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (11 results)

All 2020 2019 2018 2017

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Seasonal changes in the spermatogenesis of the large Japanese field mice (Apodemus speciosus) controlled by proliferation and apoptosis of germ cells2020

    • Author(s)
      Ito Jun、Meguro Kanna、Komatsu Kazuki、Ohdaira Takuya、Shoji Rina、Yamada Takahisa、Sugimura Satoshi、Fujishima Yohei、Nakata Akifumi、Fukumoto Manabu、Miura Tomisato、Yamashiro Hideaki
    • Journal Title

      Animal Reproduction Science

      Volume: 214 Pages: 106288-106288

    • DOI

      10.1016/j.anireprosci.2020.106288

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Radioactive Elements in Testes of Large Japanese Field Mice Using an Electron Probe Micro-Analyser after the Fukushima Accident2020

    • Author(s)
      Ohdaira T、Meguro K、Komatsu K、Syoji R、Fujishima Y、Swee Ting Goh V、Kasai K、Ariyoshi K、Nakata A、Urushihara Y、Koarai K、Kino Y、Sekine T、Suzuki M、Takahasi A、Shimizu Y、Shinoda H、Yoshida MA、Fukumoto M、Yamashiro H、Miura T
    • Journal Title

      IntechOpen

      Volume: - Pages: 1-9

    • DOI

      10.5772/intechopen.84634

    • ISBN
      9781789841411, 9781789841428
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of superovulation using inhibin antiserum and competence of embryo development in wild large Japanese field mice ( Apodemus speciosus )2019

    • Author(s)
      Meguro Kanna、Komatsu Kazuki、Ohdaira Takuya、Nakagata Naomi、Nakata Akifumi、Fukumoto Manabu、Miura Tomisato、Yamashiro Hideaki
    • Journal Title

      Reproduction in Domestic Animals

      Volume: 54 Issue: 12 Pages: 1637-1642

    • DOI

      10.1111/rda.13573

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation-induced bystander effect in large Japanese field mouse (Apodemus speciosus) embryonic cells2018

    • Author(s)
      Ariyoshi Kentaro、Miura Tomisato、Kasai Kosuke、Akifumi Nakata、Fujishima Yohei、Yoshida Mitsuaki A.
    • Journal Title

      Radiation and Environmental Biophysics

      Volume: 57 Issue: 3 Pages: 223-231

    • DOI

      10.1007/s00411-018-0743-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Attempts of radiation dose measurement in the teeth of mice living around the nuclear power plant in Fukushima using electron spin resonance spectroscopy.2017

    • Author(s)
      4.Kitaya T, Maeda T, Yasui H, Mizukawa H, Inanami O, Nakata A, Miura T, Hosokawa Y, Kuwabara M
    • Journal Title

      Radiation Environment and Medicine

      Volume: 6 Pages: 1-5

    • NAID

      40021121861

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 野生アカネズミのIVFC技術を用いた染色体数の異なる生殖能の評価2019

    • Author(s)
      目黒栞奈、小松一樹、近能真優、坂美幸、藤嶋洋平、中潟直己、中田章史、三浦富智、山城秀昭
    • Organizer
      第60回日本卵子学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Radiation-induced bystander effect in large Japanese field mouse (Apodemus speciosus) embryonic cells.2018

    • Author(s)
      有吉健太郎,三浦富智,葛西宏介,中田章史,藤嶋洋平,Goh VST,吉田光明
    • Organizer
      日本放射線影響学会第61回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 野生雌アカネズミの繁殖周期に伴うカレンダー遺伝子の発現動態2018

    • Author(s)
      小松一樹、目黒栞奈、近能真優、坂美幸、中田章史、三浦富智、山城秀昭
    • Organizer
      第67回北信越畜産学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Distribution of radioactive-caesium and cytogenetic analysis of raccoon (Procyon lotor) in Namie town, Fukushima2017

    • Author(s)
      Fujishima Y, Miura T, Ariyoshi K, Nakata A, Tazoe H, Kasai K, Valerie GST, Toyoda T, Yamada M, Yoshida MA
    • Organizer
      4th. Educational Symposium on Radiation and Health by young scientists.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 放射性物質汚染地域に生息するアカネズミ骨髄前駆細胞への放射線影響解析2017

    • Author(s)
      有吉健太郎、三浦富智、中田章史、葛西宏介、藤嶋洋平、鈴木享純、吉田光明
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 放射線汚染地域に生息するアライグマにおける放射性セシウムの臓器分布と細胞遺伝学的解析2017

    • Author(s)
      藤嶋洋平、三浦富智、有吉健太郎、中田章史、田副博文、葛西宏介、Valerie Goh Swee Ting、豊田正、山田正俊、吉田光明
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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