Study of the mechanism for alleviating "hie" (awareness of cold) by food component with thermo TRP channel

• Project/Area Number: 17K00865
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Doshisha Women's College of Liberal Arts (2018-2019); The University of Shiga Prefecture (2017)
• Principal Investigator: Mori Noriyuki 同志社女子大学, 生活科学部, 准教授 (90585184)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: TRP channel / thermo regulation / TRPM8 / awareness of cold / 体温調節 / 熱産生 / TRPチャネル / 食品 / 冷え / 温熱感覚

Outline of Final Research Achievements

The purpose of this study was to clarify the involvement of thermo TRP channels in the factors that form "hie" (awareness of cold). We found that the subjective symptom of cold may be influenced not only by the physiological thermoregulatory response to cold temperature but also by the sensitivity of TRPM8. Seasonal variation was also confirmed in the sensitivity of TRPM8 indicating that it may be affected by chronic stimulation from food components. It was suggested that the functional regulation of TRPM8 might be effective as an action point for alleviating the symptoms of "hie".

Academic Significance and Societal Importance of the Research Achievements

「冷え」は多くの若年女性が悩まされている重要な社会的問題でありQOL向上の側面からも「冷え」の全容解明およびその改善方法の開発が望まれる。本研究では温度受容TRPチャネルを介した冷え形成の生理的作用機序の理解につながる基礎的な研究としての意義が考えられる。また、温度受容TRPチャネルを利用した新たな食品摂取による冷え改善方法の考案につながる応用的な研究の第一歩となることが期待される。

Research Products

• [Presentation] 冷えの症状に対する冷感覚の感受性の関与 (2020)
  • Author(s): 森 紀之 青木 美優 中江 美沙子
  • Organizer: 日本農芸化学会2020年度大会
• [Presentation] Involvement of the vagus nerve in the enhancement of thermogenesis by agonists of TRP channels (2019)
  • Author(s): Noriyuki Mori
  • Organizer: Asian Congress of Nutrition 2019
  • Int'l Joint Research
• [Presentation] Involvement of the vagus nerve in autonomic thermoregulation responses induced by TRPM8 agonist (2019)
  • Author(s): Noriyuki Mori, Tomomi Urata, Tsutomu Fukuwatari
  • Organizer: The 9th Federation of Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] 香辛料由来TRPチャネルアゴニスト摂取による体温変化への迷走神経の関与 (2018)
  • Author(s): 森 紀之，浦田 朋実，福渡 努
  • Organizer: 第33回 日本香辛料研究会