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Investigation of vascular calcification mechanism by a new phosphorus-regulating molecule and development to CKD nutrition therapy

Research Project

Project/Area Number 17K00868
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionUniversity of Hyogo

Principal Investigator

Ito Mikiko  兵庫県立大学, 環境人間学部, 教授 (50314852)

Co-Investigator(Kenkyū-buntansha) 田中 更沙  兵庫県立大学, 環境人間学部, 助教 (90733387)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords血管石灰化 / 高リン血症 / 慢性腎臓病 / 栄養学
Outline of Final Research Achievements

Vascular calcification is major source of cardiovascular disease in patients with chronic kidney disease. Hyperphosphatemia leads to increased intracellular phosphorus (P) influx, which leads to an increase in osteoblast-like cells in vascular smooth muscle cell. However, the mechanism of vascular calcification is not completely understood. We hypothesized that P-related molecules belonging to the SLC superfamily would be involved in vascular calcification. As a result of DNA microarray analysis, we focused on SLC37A2 and showed that mRNA expression of these cells increased on calcified AoSMC. As a result, we showed that SLC37A2 is one of the molecules that increase with vascular calcification in vitro and in vivo.

Academic Significance and Societal Importance of the Research Achievements

異所性石灰化に関するSLC37A2の機能を解明するためには、さらなる研究が必要であるが、本研究の発見はリン誘発性血管石灰化のメカニズムを解明するための新しい手がかりになることが期待される。また今後、食事によるリン摂取が、SLC37A2の発現へ及ぼす影響を明らかにすることで、血管石灰化に対する新たなエビデンスにつながり、慢性腎臓病患者の食事療法の一助になることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (25 results)

All 2020 2019 2018 2017

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 9 results) Presentation (13 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] Effects of repetitive diet-induced fluctuations in plasma phosphorus on vascular calcification and inflammation in rats with early-stage chronic kidney disease2020

    • Author(s)
      Tani Mariko、Tanaka Sarasa、Takamiya Kana、Sakaue Motoyoshi、Ito Mikiko
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 66 Issue: 2 Pages: 139-145

    • DOI

      10.3164/jcbn.19-93

    • NAID

      130007804503

    • ISSN
      0912-0009, 1880-5086
    • Year and Date
      2020-03-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-fat diets provoke phosphorus absorption from the small intestine in rats.2020

    • Author(s)
      Kawamoto K, Sakuma M, Tanaka S, Masuda M, Nakao-Muraoka M, Niida Y, Nakamatsu Y, Ito M, Taketani Y, Arai H.
    • Journal Title

      Nutrition

      Volume: 72 Pages: 110694-110694

    • DOI

      10.1016/j.nut.2019.110694

    • NAID

      120006939630

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SLC37A2, a phosphorus-related molecule, increases in smooth muscle cells in the calcified aorta2020

    • Author(s)
      Tani M, Tanaka S, Oeda C, Azumi Y, Kawamura H, Sakaue M, Ito M
    • Journal Title

      J Clin Biochem Nutr.

      Volume: in press

    • NAID

      130007965281

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of dietary fiber on vascular calcification by repetitive diet-induced fluctuations in plasma phosphorus in early-stage chronic kidney disease rats.2020

    • Author(s)
      Tani M, Tanaka S, Takamiya K, Kato Y, Harata G, He F, Sakaue M, Ito M
    • Journal Title

      J Clin Biochem Nutr.

      Volume: in press

    • NAID

      130007934161

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation.2019

    • Author(s)
      Fujii T, Segawa H, Hanazaki A, Nishiguchi S, Minoshima S, Ohi A, Tominaga R, Sasaki S, Tanifuji K, Koike M, Arima Y, Shiozaki Y, Kaneko I, Ito M, Tatsumi S, Miyamoto KI
    • Journal Title

      Clin Exp Nephrol.

      Volume: in press Issue: 7 Pages: 898-907

    • DOI

      10.1007/s10157-019-01725-6

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase2019

    • Author(s)
      Nitta Yoko、Ito Hideyuki、Komori Hirohumi、Ueno Hiroshi、Takeshima Daiki、Ito Mikiko、Sakaue Motoyoshi、Kikuzaki Hiroe
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 印刷中 Issue: 7 Pages: 1315-1318

    • DOI

      10.1080/09168451.2019.1606695

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney.2019

    • Author(s)
      Fujii T, Shiozaki Y, Segawa H, Nishiguchi S, Hanazaki A, Noguchi M, Kirino R, Sasaki S, Tanifuji K, Koike M, Yokoyama M, Arima Y, Kaneko I, Tatsumi S, Ito M, Miyamoto KI.
    • Journal Title

      Clin Exp Nephrol

      Volume: 23(3) Issue: 3 Pages: 313-324

    • DOI

      10.1007/s10157-018-1653-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 血中リンと血管内皮機能に及ぼす水溶性食物繊維の効果2018

    • Author(s)
      河村弘美、阪上詩織、田中更沙、松井麻有、谷真理子、石谷翠里、坂上元祥、伊藤美紀子
    • Journal Title

      日本病態栄養学会誌

      Volume: 21(4) Pages: 495-503

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dietary intake of inorganic phosphorus has a stronger influence on vascular-endothelium function than organic phosphorus2018

    • Author(s)
      Kawamura H, Tanaka S, Ota Y, Endo S, Tani M, Ishitani M, Sakaue M, Ito M
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 62 Issue: 2 Pages: 167-173

    • DOI

      10.3164/jcbn.17-97

    • NAID

      130006407515

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypophosphatemia occurs with insulin administration during refeeding by total parenteral nutrition in rats2018

    • Author(s)
      Kawamura H, Tanaka S, Uenami Y, Tani M, Ishitani M, Morii S, Sakaue M, Ito M
    • Journal Title

      The Journal of Medical Investigation

      Volume: 65 Issue: 1.2 Pages: 50-55

    • DOI

      10.2152/jmi.65.50

    • NAID

      130006575588

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cytotoxic and cytoprotective effects of tryptamine-4,5-dione on neuronal cells: a double-edged sword2017

    • Author(s)
      Suga Naoko、Murakami Akira、Nakamura Yoshimasa、Ishisaka Akari、Kitamoto Noritoshi、Ito Mikiko、Kato Yoji
    • Journal Title

      Free Radical Research

      Volume: 51 Issue: 5 Pages: 545-553

    • DOI

      10.1080/10715762.2017.1331038

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] リフィーディング時におけるインスリン分泌能にリンが及ぼす影響2020

    • Author(s)
      田中更沙、本玉紗友香、尾田桃子、河村弘美、谷真理子、坂上元祥、伊藤美紀子
    • Organizer
      第23回日本病態栄養学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 軽度リフィーディングシンドロームにおけるリン・糖代謝への影響2019

    • Author(s)
      田中更沙、本玉紗友香、尾田桃子、 河村弘美、井元夢乃、浦田侑里、谷真理子、坂上元祥、伊藤美紀子
    • Organizer
      第73回 日本栄養・食糧学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食餌による一過性血中リン濃度上昇の反復が血管へ及ぼす影響2019

    • Author(s)
      谷 真理子、田中更沙、高宮佳奈、坂上元祥、伊藤美紀子
    • Organizer
      第7回 日本腎栄養代謝研究会 学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of diet-induced repetitive spikes in plasma phosphorus on vascular calcifications in rats with mild kidney dysfunction.2019

    • Author(s)
      M. Tani, K. Takamiya, S. Tanaka, M. Sakaue, M. Ito
    • Organizer
      41th European Society for Clinical Nutrition and Metabolism Congress :ESPEN
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of soluble dietary fiber on plasma phosphorus and endothelial function.2019

    • Author(s)
      Tanaka S, Tani M, Kawamura H, Sakaue S, Matsui M, Ishitani1 M, Sakaue M, Ito M.
    • Organizer
      The 7th International Conference on Food Factors(ICoFF)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血中リンと血管内皮機能に及ぼす水溶性食物繊維の効果2019

    • Author(s)
      谷真理子、田中更沙、河村弘美、阪上詩織、松井麻有、石谷翠里、坂上元祥、伊藤美紀子
    • Organizer
      第22回日本病態栄養学会年次学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 低リン血症を呈するリフィーディングシンドロームモデルラットの構築2018

    • Author(s)
      田中更沙、河村弘美、上波友理、井元夢乃、浦田侑里、谷真理子、石谷翠里、森井沙衣子、坂上元祥、伊藤美紀子
    • Organizer
      第72回 日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 水溶性食物繊維による血中リンおよび血管内皮機能への効果2018

    • Author(s)
      田中更沙、谷真理子、河村弘美、阪上詩織、松井麻有、石谷翠里、坂上元祥、伊藤美紀子
    • Organizer
      第57回 日本栄養・食糧学会近畿支部大会
    • Related Report
      2018 Research-status Report
  • [Presentation] TPNを用いたリフィーディングシンドロームモデルラットの構築2018

    • Author(s)
      河村弘美、田中更沙、谷真理子、石谷翠里、森井沙衣子、坂上元祥、伊藤美紀子
    • Organizer
      第21回日本病態栄養学会年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] マヌカ蜂蜜に含まれるレプトスペリン及びメチルシリンゲートの培養細胞を用いた代謝研究2018

    • Author(s)
      加藤陽二、室田佳恵子、石坂朱里、伊藤美紀子、生城真一
    • Organizer
      日本農芸化学会2018
    • Related Report
      2017 Research-status Report
  • [Presentation] リフィーディングにおいてリンが急性期の糖代謝に及ぼす影響2017

    • Author(s)
      河村弘美、上波友理、増田円、谷真理子、石谷翠里、大枝千紘、松井麻有、田中更沙、伊藤美紀子
    • Organizer
      第71回日本栄養・食糧学会年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 特定健康診査結果を用いた健康課題抽出と食生活・栄養摂取状況との関連2017

    • Author(s)
      石谷翠里、河村弘美、谷真理子,田中更沙、福井充,坂本薫,伊達ちぐさ,伊藤美紀子(
    • Organizer
      第64回 日本栄養改善学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Dietary intake of inorganic phosphorus rather than organic phosphorus impairs endothelial function in healthy young men.2017

    • Author(s)
      Kawamura H, Ota Y, Endo S, Tani M, Ishitani M, Tanaka S, Sakaue M, Ito M
    • Organizer
      39th ESPEN congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] リンの事典2017

    • Author(s)
      大竹久夫、杉山茂、佐竹研一、小野寺真一、黒田章夫、竹谷豊、橋本光史、三島慎一郎、村上孝雄、伊藤美紀子 他
    • Total Pages
      360
    • Publisher
      朝倉書店
    • ISBN
      9784254141047
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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