Effects of omega-3 fatty acids on human brown adipose tissue
| Project/Area Number |
17K00872
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Tenshi College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
斉藤 昌之 北海道大学, 獣医学研究院, 名誉教授 (80036441)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 褐色脂肪 / ω3脂肪酸 / 肥満・メタボ / 魚油 / 褐色脂肪組織 / メタボ / ω３脂肪酸 / ω脂肪酸 / メタボリックシンドローム |
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| Outline of Final Research Achievements |
The effect of ω3 fatty acids on whole-body energy expenditure via brown adipose tissue (BAT) was examined. Energy expenditure was measured after consumption of a high-fat diet high in ω3 fatty acids, a simple high-fat diet, and an ω3 fatty acid supplement on different days. Energy expenditure was higher in the BAT hyperactive subjects, but not significantly so. Consideration of fat digestion and absorption time needs to be considered. In a 6-week continuous intake study of ω3 fatty acid supplements in BAT low activators, there was a significant increase in cold-induced thermogenesis after intake and an increase in lean body mass. Based on these findings, it is possible that a constant intake of ω3 fatty acids on a regular basis can increase brown fat activity.
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| Academic Significance and Societal Importance of the Research Achievements |
ヒトの褐色脂肪はエネルギー消費や体脂肪量の調節に寄与する、褐色脂肪の機能低下が肥満を誘発する、寒冷馴化や香辛料などの食品成分摂取によって褐色脂肪が活性化・増量し肥満が軽減する、グルコースの恒常性やHbA1cに影響を与えるなどの事実を明らかにし、褐色脂肪をターゲットとした新たな肥満・メタボ対策をこれまでに提示してきた。本研究ではマウスで報告のあったω3脂肪酸に焦点を当て調査を行い、ヒトでも同様の効果を得ることができた。日本人の食事摂取基準ではω3脂肪酸の目安量が示されているが、肥満・メタボ対策としても毎日摂取することの重要性を示すことができた。
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Report
(6 results)
Research Products
(46 results)
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[Journal Article] BCAA catabolism in brown fat controls energy homeostasis through SLC25A442019
Author(s)
Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White P J, McGarrah R W, Ilkayeva O R, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton C H, Pradhan R N, Majd H, Greiner V J, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, et al
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Journal Title
Nature
Volume: 572
Issue: 7771
Pages: 614-619
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Human brown adipose tissue density evaluated by near-infrared time-resolved spectroscopy2018
Author(s)
Takafumi Hamaoka, Shinsuke Nirengi, Sayuri Fuse, Shiho Amagasa, Toshiyuki Homma, Ryotaro Kime, Tasuki Endo, Naoki Sakane, Mami Matsushita, Masayuki Saito, Takeshi Yoneshiro, Yuko Kurosawa
Organizer
The Second Britton Chance International Symposium on Metabolic Imaging and Spectroscopy HONORING THE 105th BIRTHDAY OF BRITTON CHANCE
Related Report
Int'l Joint Research
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[Presentation] 寒冷曝露による呼気アセトン濃度の変化2018
Author(s)
同道正行, 二連木晋輔, 若林斉, 松下真美, 鈴木新一, 竹下尚男, 河口八重子, 菅沼彰子, 鋤納心, 斉藤昌之, 坂根直樹
Organizer
第39回日本肥満学会
Related Report
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[Presentation] Non-invasive evaluation of human brown adipose tissue using infrared thermography2018
Author(s)
Shinsuke Nirengi, Hitoshi Wakabayashi, Mami Matsushita, Masayuki Domichi, Shinichi Suzuki, Shin Sukino, Akiko Suganuma, Yaeko Kawaguchi, Takeshi Hashimoto, Masayuki Saito, Naoki Sakane
Organizer
The 12th International Diabetes Federation Western Pacific Region Congress
Related Report
Int'l Joint Research
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[Presentation] Supraclavicular tissue total hemoglobin determined by near-infrared time-resolved spectroscopy as indicators of brown adipose tissue characteristics in humans2018
Author(s)
Takafumi Hamaoka, Shinsuke Nirengi, Sayuri Fuse, Shiho Amagasa, Toshiyuki Homma, Ryotaro Kime, Miyuki Kuroiwa, Tasuki Endo, Naoki Sakane, Mami Matsushita, Masayuki Saito, Takeshi Yoneshiro, Yuko Kurosawa
Organizer
International Symposium Role of Brown Adipose Tissue in Human Health
Related Report
Int'l Joint Research
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[Presentation] Diurnal variation of postprandial thermogenesis and substrate oxidation in humans: Involvement of brown adipose tissue2017
Author(s)
Mami Matsushita, Masanobu Hibi, Sachiko Oishi, Takeshi Yoneshiro, Tohru Yamaguchi, Chiyoko Usui, Koichi Yasunaga, Yoshihisa Katsuragi, Kazuo Kubota, Shigeho Tanaka , Masayuki Saito
Organizer
4th international conference on Recent Advances and Controversies in Measuring Energy Metabolism
Related Report
Int'l Joint Research
