Functional elucidation of anticancer effects of sesame lignans
Project/Area Number |
17K00874
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Eating habits
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Research Institution | Tohoku Medical and Pharmaceutical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
蓬田 伸 東北医科薬科大学, 薬学部, 准教授 (80230845)
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Project Period (FY) |
2017-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | ゴマリグナン類 / セサミン / セサモール / 抗がん作用 / 細胞増殖抑制作用 / アポトーシス誘導 / 薬剤耐性 / 網羅的なタンパク質解析 / 網羅的タンパク質解析 / 機能性食品 |
Outline of Final Research Achievements |
Sesame lignans, specifically sesamin and sesamol, have gained attention for their potential as physiologically active substances with antioxidant properties. These lignans are known to have the ability to remove active oxygen, which is considered one of the causes of cancer. My research has explored the anticancer activity of sesamin and sesamol, particularly in relation to K562 cells. My Studies have confirmed the anticancer effects of sesamin and sesamol on K562 cells, a type of cancer cell line. What is particularly noteworthy is that these lignans have also demonstrated anticancer effects on K562/DOX cells. K562/DOX cells are a drug-resistant variant of K562 cells, meaning they have become resistant to conventional anticancer drugs such as doxorubicin. The fact that sesamin and sesamol still exhibit anticancer effects on these drug-resistant cells suggests their potential usefulness for cancer patients who have become unresponsive to traditional chemotherapy.
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Academic Significance and Societal Importance of the Research Achievements |
ゴマリグナンの一種であるセサミン及びセサモールの抗がん作用(細胞増殖抑制作用)を確認した。K562細胞に対してセサミン及びセサモールは細胞増殖抑制作用を示した。注目すべき点はK562/DOX細胞に対しても、セサミン及びセサモールは細胞増殖抑制作用を示した。このことは、抗がん剤が効きにくくなったがん患者に対しても(薬剤耐性患者)セサミン及びセサモールによる抗がん作用の期待が持てる。また、セサミン及びセサモールは健康に良い食品やサプリメントとして摂取可能であることから、がんの予防、治療に関連する医療費の増加を大幅に抑制できる。
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Report
(7 results)
Research Products
(69 results)
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[Journal Article] Electrochemical Polymerization of Nitroxyl Radical Precursor Containing Phenol Side Chain in Aqueous Solution and Its Application to Electrochemical Analysis of Glucose2022
Author(s)
Katsuhiko Sato, Masayuki Kumano, Kyoko Sugiyama, Sachiko Komatsu, Kazuhiro Watanabe, Ryota Imahashi , Tetsuya Ono , Kentaro Yoshida , Takenori Dairaku , Tsutomu Fujimura, Yoshitomo Kashiwagi
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Journal Title
BUNSEKI KAGAKU
Volume: 71
Issue: 3
Pages: 191-196
DOI
ISSN
0525-1931
Year and Date
2022-03-05
Related Report
Peer Reviewed
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[Journal Article] Electrochemical evaluation of nitroxyl radical catalysts and electrochemical detection of cyclosporin A2021
Author(s)
Sachiko Komatsu, Yusuke Sasano , Kyoko Sugiyama, Kazuhiro Watanabe, Masayuki Kumano, Kentaro Yoshida , Tetsuya Ono , Yoshiharu Iwabuchi , Tsutomu Fujimura, Katsuhiko Sato, Yoshitomo Kashiwagi
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Journal Title
International Journal of electrochemical science
Volume: 16
Pages: 20127-20127
Related Report
Peer Reviewed
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[Journal Article] Catalysis of electro-oxidation of antibiotics by nitroxyl radicals and the electrochemical sensing of vancomycin2021
Author(s)
Tetsuya Ono , Kyoko Sugiyama, Sachiko Komatsu, Masayuki Kumano, Kentaro Yoshida , Takenori Dairaku , Tsutomu Fujimura, Yusuke Sasano b, Yoshiharu Iwabuchi , Yoshitomo Kashiwagi , Katsuhiko Sato
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Journal Title
RSC Advances
Volume: 11
Issue: 35
Pages: 21622-21628
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A2021
Author(s)
Sachiko Komatsu, Yusuke Sasano, Kyoko Sugiyama, Kazuhiro Watanabe, Masayuki Kumano, Kentaro Yoshida, Tetsuya Ono, Yoshiharu Iwabuchi, Tsutomu Fujimura, Katsuhiko Sato, Yoshitomo Kashiwagi
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Journal Title
International Journal of Electrochemical Science
Volume: 16
Issue: 2
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tranilast inhibits pulmonary fibrosis by suppressing TGFβ/SMAD2 pathway2020
Author(s)
Motoyasu Kato, Fumiyuki Takahashi, Tadashi Sato, Yoichiro Mitsuishi, Ken Tajima, Hiroaki Ihara, Fariz Nurwidya, Hario Baskoro, Akiko Murakami, Isao Kobayashi, Moulid Hidayat, Naoko Shimada, Shinichi Sasaki, Reiko Mineki, Tsutomu Fujimura, Toshio Kumasaka, Shin Ichiro Niwa, Kazuhisa Takahashi
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Journal Title
Drug Design, Development and Therapy
Volume: 14
Pages: 4593-4603
DOI
Related Report
Peer Reviewed
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[Journal Article] Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in Cerebral Ischemia/Reperfusion Injury2019
Author(s)
Kishimoto M, Suenaga J, Takase H, Araki K, Yao T, Fujimura T, Murayama K, Okumura K, Ueno R, Shimizu N, Kawahara N, Yamamoto T, Seko Y.
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Journal Title
Sci Rep.
Volume: 9(1)
Issue: 1
Pages: 13512-13512
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Characteristics of hepatic insulin-sensitive nonalcoholic fatty liver disease.2017
Author(s)
Shigiyama F, Kumashiro N, Furukawa Y, Funayama T, Takeno K, Wakui N, Ikehara T, Nagai H, Taka H, Fujimura T, Uchino H, Tamura Y, Watada H, Nemoto T, Shiraga N, Sumino Y, Hirose T.
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Journal Title
Hepatol Commun.
Volume: 1
Issue: 7
Pages: 634-647
DOI
Related Report
Peer Reviewed / Open Access
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[Book] 臨床病理2020
Author(s)
諏訪部 章, 共著
Total Pages
289
Publisher
日本臨床検査医学会
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