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Dietary Behavior and Diabetes: An Analysis of Brain-Gut Axis Mechanisms

Research Project

Project/Area Number 17K00924
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionFukushima Medical University

Principal Investigator

KUDO AKIHIRO  福島県立医科大学, 医学部, 講師 (20528096)

Co-Investigator(Kenkyū-buntansha) 島袋 充生  福島県立医科大学, 医学部, 教授 (60271144)
旭 浩一  岩手医科大学, 医学部, 教授 (60274966)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糖尿病 / 食行動 / 脳腸相関 / 食行動異常 / 腸内フローラ
Outline of Final Research Achievements

We investigated the effect of eating behavior on the onset of new diabetes using a in a nation-wide Japanese cohort. We revealed that fast eating is a strong risk factor for new-onset diabetes. In addition, in exercise habits, fast walking suppresses the onset of new diabetes.
We have created a comprehensive database of eating behaviors, cognitive functions, motor functions, and body compositions of our outpatients, and have completed the registration of about 700 patients by the end of 2019. By analyzing the database, we found that diabetic patients with slow walking speed have increased mild cognitive impairment (MCI), and that decreased skeletal muscle index is an independent risk factor for bone loss.

Academic Significance and Societal Importance of the Research Achievements

我々の研究では、①早食いをしないこと、②早歩きをすることが、糖尿病の予防につながる可能性があることが分かりました。2008~2011年にかけて、全国都道府県で特定健診を受けた約20万人について調査をしました。そのうち、7032人(3.6%)が新たに糖尿病になりました。特定検診では食行動に関して4つの問診項目がありますが、そのうち「食べる速度が早い」を選択した群のみで、新規糖尿病発症者が多くなりました。また、運動に関する3つの問診項目のうち、「人と比べて歩く速度が早い」群のみで、糖尿病発症者が少なくなりました。「早食い」と「早歩き」、これらに心がけて、糖尿病を予防することが大切だと分かりました。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2021 2020 2019 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (3 results)

  • [Journal Article] Fast walking is a preventive factor against new-onset diabetes mellitus in a large cohort from a Japanese general population2021

    • Author(s)
      Iwasaki M, Kudo A, Asahi K, Machii N, Iseki K, Satoh H, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Shibagaki Y, Kasahara M, Watanabe T, Shimabukuro M
    • Journal Title

      Sci Rep

      Volume: 11(1) Issue: 1 Pages: 716-716

    • DOI

      10.1038/s41598-020-80572-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Walking Speed is the Sole Determinant Criterion of Sarcopenia of Mild Cognitive Impairment in Japanese Elderly Patients with Type 2 Diabetes Mellitus2020

    • Author(s)
      Machii Noritaka、Kudo Akihiro、Saito Haruka、Tanabe Hayato、Iwasaki Mariko、Hirai Hiroyuki、Masuzaki Hiroaki、Shimabukuro Michio
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 7 Pages: 2133-2133

    • DOI

      10.3390/jcm9072133

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fast eating is a strong risk factor for new-onset diabetes among the Japanese general population2019

    • Author(s)
      Akihiro Kudo
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 8210-8210

    • DOI

      10.1038/s41598-019-44477-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 糖尿病患者における骨密度低下リスク因子の解析2020

    • Author(s)
      工藤 明宏
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食行動要因の糖尿病新規発症におよぼす影響:特定健診受診者における解析2017

    • Author(s)
      工藤 明宏
    • Organizer
      日本糖尿病学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 早食いにより糖尿病発症は増加する2017

    • Author(s)
      工藤 明宏
    • Organizer
      日本肥満学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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