Effect of time-restricted feeding on sleep-wake cycle and neural substrate of the phenomenon
| Project/Area Number |
17K00932
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Tohoku Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 睡眠 / ノンレム睡眠 / レム睡眠 / 呼吸リズム / 測定器 / 睡眠ステージ / ウェアラブルセンサ / 食事 / 生体リズム / 呼吸 / 睡眠-覚醒状態 / 脳波 / 睡眠ステージング / 行動解析 / 機械学習 / 制限給餌 / 時間生物 / 心電図測定 / 脳波測定 / 食事制限 / 生体生命情報学 / 神経科学 |
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| Outline of Final Research Achievements |
This study aimed to examine the effects on sleep of restricted feeding on a schedule that mimics our daily mean schedule. In this study, a system to stably measure sleep over a long period was needed, and we developed two measurement systems. The first was a small amplifier and logger for measuring sleep EEG in rats. In general, electrodes implanted in the head are connected to an amplifier by a cable, and this is not suitable for long-term measurement because it restricts their activities. The small amplifier-cum-logger we have developed solved the problem. In addition, we also developed a measurement device for respiration and a method for sleep scoring to reduce the burden on animals.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の最も大きな成果は、睡眠研究に必要な脳波・呼吸信号を長期間安定に測定できるげっ歯類用の測定システムを開発したことである。睡眠の制御に関わる神経機構や分子機構の解明、睡眠薬の開発は主にげっ歯類を用いた動物実験により進められていることから、本研究での成果は睡眠研究の発展に寄与するものであると考える
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Report
(6 results)
Research Products
(22 results)
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[Journal Article] Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep-wake states2020
Author(s)
A. Natsubori, T. Tsunematsu, A. Karashima, H. Imamura, N. Kabe, A. Trevisiol, J. Hirrlinger, T. Kodama, T. Sanagi, K. Masamoto, N. Takata, K-A Nave, K. Matsui, K.F. Tanaka, M. Honda
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Journal Title
Communications Biology
Volume: 3
Issue: 1
Pages: 491-491
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] 睡眠学2020
Author(s)
本多和樹、辛島彰洋ら
Total Pages
712
Publisher
朝倉書店
ISBN
9784254301205
Related Report
