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Assessment of myocardial stiffness using the analysis of subtle myocardial deformation

Research Project

Project/Area Number 17K01410
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionOsaka University

Principal Investigator

Asanuma Toshihiko  大阪大学, 医学系研究科, 招へい教授 (80379271)

Co-Investigator(Kenkyū-buntansha) 増田 佳純  大阪大学, 医学系研究科, 助教 (20533293)
中谷 敏  大阪大学, 医学系研究科, 教授 (80393221)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords心不全 / 心エコー / 心筋ストレイン
Outline of Final Research Achievements

In the ischemic heart disease, the risk of heart failure is affected by myocardial stiffness. However, it has been difficult to estimate regional myocardial stiffness by using conventional echocardiography. We hypothesized that the analysis of subtle myocardial deformation such as early systolic lengthening (ESL) or post-systolic shortening (PSS) by speckle-tracking echocardiography allowed quantitative evaluation of stiffness in the ischemic myocardium. In animal ischemia models, we demonstrated that the analyses of ESL and PSS might be useful to estimate regional myocardial stiffness.

Academic Significance and Societal Importance of the Research Achievements

心臓の硬さの計測には、侵襲的なカテーテル法を用いた心内圧と容積の同時測定が必要であるが、臨床でこれを評価することは難しい。したがって、非侵襲的診断法の確立は、循環器領域における最重要課題の一つとみなされている。局所組織の硬さを非侵襲的に推定する方法として集束超音波を利用した方法があるが、動的臓器である心臓においては測定が困難であった。われわれが考案した微細心筋運動解析による推定は臨床でも可能であり、その意義は極めて大きいと考える。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2020 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Deterioration of longitudinal, circumferential, and radial myocardial strains during acute coronary flow reduction: which direction of strain should be analyzed for early detection?2020

    • Author(s)
      Adachi H, Asanuma T, Masuda K, Nakatani S.
    • Journal Title

      Int J Cardiovasc Imaging

      Volume: -

    • NAID

      120007184988

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of myocardial ischemic memory using three-dimensional speckle-tracking echocardiography: a novel integrated analysis of early systolic lengthening and postsystolic shortening2019

    • Author(s)
      Kozuma A, Asanuma T, Masuda K, Adachi H, Minami S, Nakatani S.
    • Journal Title

      J Am Soc Echocardiogr

      Volume: 32 Issue: 11 Pages: 1477-1486

    • DOI

      10.1016/j.echo.2019.06.013

    • NAID

      120006961013

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Noninvasive assessment of ischemic myocardial stiffness using subtle myocardial deformation derived from speckle tracking echocardiography2018

    • Author(s)
      Masuda K, Asanuma T, Kozuma A, Minami S, Takeda S, Nakayama T, Nakatani S
    • Organizer
      Echo Asia 2018, Jeju, Korea
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 虚血心筋における心筋スティッフネスの評価:スペックルトラッキング法を用いた検討2018

    • Author(s)
      増田佳純、浅沼俊彦, 足立 瞳, 小妻 愛, 南 星奈, 竹田瀬里奈, 中山智仁, 中谷 敏
    • Organizer
      日本超音波医学会第91回学術集会, 神戸
    • Related Report
      2018 Research-status Report
  • [Presentation] Assessment of spatial extent of myocardial ischemic memory using three-dimensional speckle tracking echocardiography2018

    • Author(s)
      Kozuma A, Asanuma T, Masuda K, Minami S, Takeda S, Nakayama T, Nakatani S
    • Organizer
      American Heart Association Scientific Session 2018, Chicago, illinois, USA
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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