Evaluation of qualitative and quantitative changes of fatty acids: clinical application of a novel intervention program in patients with frailty and cardiovascular diseases

• Project/Area Number: 17K01470
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Juntendo University
• Principal Investigator: Kazunori Shimada 順天堂大学, 大学院医学研究科, 客員准教授 (60327814)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 心血管疾患 / 脂肪酸 / リン脂質 / フレイル / 心臓リハビリテーション / 心臓MRS法 / 心筋内中性脂肪

Outline of Final Research Achievements

Clinical studies: We have presented the following findings: 1) the associations between qualitative and quantitative changes of fatty acids (EPA, DHA, EPA/AA, DHA/AA), and cardiovascular diseases (acute coronary syndrome, ischemic stroke, abdominal aortic aneurysm, atrial fibrillation, acute thromboembolism, heart failure), 2) trait anxiety only improved in the non-frail group after cardiac rehabilitation, and 3) the myocardial triglyceride content using proton magnetic resonance spectroscopy decreased in a patient with TGCV.
Basic studies: We have presented the following findings: 1) Nox4 deficiency attenuated angiotensin II-induced muscle wasting, partially through the regulation of Nrf2, 2) the accumulation of EPA-derived and DHA-derived metabolites in the sarcopenic muscle of aged mice, and 3) voluntary exercise after myocardial infarction improved cardiac remodeling associated with anti-inflammatory effects in the myocardium and myokine production in the skeletal muscles.

Academic Significance and Societal Importance of the Research Achievements

本研究は、種々の心血管疾患において血中脂肪酸分画の質的量的変化がそれぞれの病態や予後に関連すること、フレイルや骨格筋機能に関連する代謝物やマイオカインが心血管疾患の病態に関連すること、TGCV患者において1H-MRS法は非侵襲的に心筋内TG量を測定できることを確認した。基礎研究では、リン脂質代謝、特にEPA代謝異常が加齢に伴う筋萎縮に関連すること、自発運動は心筋梗塞部位や骨格筋における炎症やミトコンドリア機能の制御により心機能改善に関与することを明らかにした。これらの結果から、フレイルに対する心臓リハのメカニズムを明らかにし、今後の新規心臓リハ開発と臨床応用に繋がる課題を見出すことが出来た。

Research Products

• [Journal Article] Study Protocol of Cardiac Rehabilitation for Acute Myocardial Infarction From the JROAD/JROAD-DPC Database ― JROAD-CR ― (2023)
  • Author(s): Suematsu Yasunori、Miura Shin-ichiro、Minei Akira、Sumita Yoko、Kanaoka Koshiro、Nakai Michikazu、Arima Hisatomi、Nakamura Koshi、Takura Tomoyuki、Shimada Kazunori、Shiraishi Hirokazu、Fukuma Nagaharu、Ohya Yusuke、Makita Shigeru、The JROAD-CR Investigators
  • Journal Title: Circulation Reports Volume: 5 Issue: 2 Pages: 62-65
  • DOI: 10.1253/circrep.CR-22-0121
  • ISSN: 2434-0790
  • Year and Date: 2023-02-10
  • Peer Reviewed / Open Access
• [Journal Article] 1H-MRS to evaluate improved triglyceride accumulation in idiopathic triglyceride deposit cardiomyovasculopathy after CNT-01 (tricaprin/trisdecanoin) administration (2023)
  • Author(s): Aikawa Tatsuro、Sai Eiryu、Kudo Ayako、Kawaguchi Yuko O、Takamura Kazuhisa、Hiki Makoto、Yokoyama Takayuki、Miyazaki Tetsuro、Fujimoto Shinichiro、Shimada Kazunori、Hirano Ken-ichi、Daida Hiroyuki、Minamino Tohru
  • Journal Title: Endocrinology, Diabetes & Metabolism Case Reports Volume: 2023 Issue: 2 Pages: 22-0370
  • DOI: 10.1530/edm-22-0370
  • Peer Reviewed / Open Access
• [Journal Article] Nutritional Status in Patients Undergoing Phase II Cardiac Rehabilitation by Mini Nutritional Assessment (2023)
  • Author(s): Nozawa Yosuke、Nishitani-Yokoyama Miho、Shimada Kazunori、Kasuya Hiroki、Kunimoto Mitsuhiro、Fujiwara Kei、Doi Mayumi、Sato Yusei、Nishimura Junya、Xu Jianying、Abulimiti Abidan、Tabata Minoru、Minamino Tohru
  • Journal Title: Cardiology Research Volume: 14 Issue: 2 Pages: 133-141
  • DOI: 10.14740/cr1479
  • Peer Reviewed / Open Access
• [Journal Article] Accumulation of polyunsaturated fatty acid-derived metabolites in the sarcopenic muscle of aging mice (2023)
  • Author(s): Kadoguchi T, Shimada K, Fukui N, Tanaka N, Tsuno H, Shiozawa T, Fukao K, Nishitani-Yokoyama M, Isoda K, Matsushita S, Yokoyama N, Daida H.
  • Journal Title: Geriatrics and Gerontology International Volume: 23 Issue: 4 Pages: 297-303
  • DOI: 10.1111/ggi.14561
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] JCS/JACR 2021 Guideline on Rehabilitation in Patients With Cardiovascular Disease (2022)
  • Author(s): Makita Shigeru、Yasu Takanori、Akashi Yoshihiro J、Adachi Hitoshi、Izawa Hideo、Ishihara Shunichi、Iso Yoshitaka、Ohuchi Hideo、Omiya Kazuto、Ohya Yusuke、Okita Koichi、Kimura Yutaka、Koike Akira、Kohzuki Masahiro、Koba Shinji、Sata Masataka、Shimada Kazunori、et al.
  • Journal Title: Circulation Journal Volume: 87 Issue: 1 Pages: 155-235
  • DOI: 10.1253/circj.CJ-22-0234
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2022-12-23
  • Peer Reviewed / Open Access
• [Journal Article] Study Design of the Japanese Association of Cardiac Rehabilitation Registry (J-CARRY) ― Protocol for a Prospective, Multicenter, Open Registry ― (2022)
  • Author(s): Kida Keisuke、Nishitani-Yokoyama Miho、Shimada Kazunori、et al.
  • Journal Title: Circulation Reports Volume: 4 Issue: 11 Pages: 550-554
  • DOI: 10.1253/circrep.CR-22-0071
  • ISSN: 2434-0790
  • Year and Date: 2022-11-10
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Phase II Cardiac Rehabilitation on Physical Function and Anxiety Levels in Frail Patients (2022)
  • Author(s): Honzawa Akio、Nishitani-Yokoyama Miho、Shimada Kazunori、Kunimoto Mitsuhiro、Matsubara Tomomi、Matsumori Rie、Kasuya Hiroki、Fujiwara Kei、Doi Mayumi、Takagi-Kawahara Kana、Abulimiti Abidan、Xu Jianying、Shimada Akie、Yamamoto Taira、Amano Atsushi、Asai Tohru、Daida Hiroyuki、Minamino Tohru
  • Journal Title: Circulation Reports Volume: 4 Issue: 7 Pages: 308-314
  • DOI: 10.1253/circrep.CR-22-0008
  • ISSN: 2434-0790
  • Year and Date: 2022-07-08
  • Peer Reviewed / Open Access
• [Journal Article] ¹²³I-BMIPP Scintigraphy Shows That CNT-01 (Tricaprin) Improves Myocardial Lipolysis in Patients with Idiopathic Triglyceride Deposit Cardiomyovasculopathy (2022)
  • Author(s): Miyauchi Hideyuki、Hirano Ken-ichi、Nakano Yusuke、Shimada Kazunori、Nishikawa Mitsunori、Yamamoto Hiroyuki、Nakamura Ayumi、Miyake Akimitsu、Aoshima Chihiro、Fujimoto Shinichiro、Nakatani Daisaku、Yamada Tomomi、Amano Tetsuya、Nakajima Kenichi
  • Journal Title: Annals of Nuclear Cardiology Volume: 8 Issue: 1 Pages: 67-75
  • DOI: 10.17996/anc.22-00167
  • ISSN: 2189-3926, 2424-1741
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of 123I-BMIPP washout rate in patients with uncertain chronic heart failure (2022)
  • Author(s): Aoshima C、Fujimoto S、Kudo A、Kawaguchi Y O.、Takamura K、Matsue Y、Kato T、Kawamura Y、Kimura S、Kamo Y、Nozaki Y O.、Takahashi D、Tomizawa N、Hiki M、Kasai T、Nojiri S、Miyauchi H、Hirano Ki、Shimada K、Murakami K、Minamino T
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 49 Issue: 9 Pages: 3129-3139
  • DOI: 10.1007/s00259-022-05749-1
  • Peer Reviewed / Open Access
• [Journal Article] Safety and Efficacy of Simultaneous Inoculations of Pneumococcal and Influenza Vaccines in Patients with Coronary Artery Disease (2021)
  • Author(s): Shimada Kazunori、Morinaga Hiroaki、Kiyanagi Takashi、Miyazaki Tetsuro、Nishitani-Yokoyama Miho、Okai Iwao、Tamura Hiroshi、Konishi Hakuoh、Kurata Takeshi、Miyauchi Katsumi、Daida Hiroyuki
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 8 Pages: 826-834
  • DOI: 10.5551/jat.58297
  • NAID: 130008070397
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Triglyceride Deposit Cardiomyovasculopathy with Massive Myocardial Triglyceride which Was Proven Using Proton-magnetic Resonance Spectroscopy (2021)
  • Author(s): Sai Eiryu、Shimada Kazunori、Aikawa Tatsuro、Aoshima Chihiro、Takamura Kazuhisa、Hiki Makoto、Yokoyama Takayuki、Miyazaki Tetsuro、Fujmoto Shinichiro、Konishi Hakuoh、Hirano Ken-ichi、Daida Hiroyuki、Minamino Tohru
  • Journal Title: Internal Medicine Volume: 60 Issue: 8 Pages: 1217-1220
  • DOI: 10.2169/internalmedicine.6126-20
  • NAID: 130008025048
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2021-04-15
  • Peer Reviewed / Open Access
• [Journal Article] Arterial Stiffness Index and Exercise Tolerance in Patients Undergoing Cardiac Rehabilitation (2021)
  • Author(s): Fujiwara Kei、Shimada Kazunori、Nishitani-Yokoyama Miho、Kunimoto Mitsuhiro、Matsubara Tomomi、Matsumori Rie、Abulimiti Abidan、Aikawa Tatsuro、Ouchi Shohei、Shimizu Megumi、Fukao Kosuke、Miyazaki Tetsuro、Honzawa Akio、Yamada Miki、Saitoh Masakazu、Morisawa Tomoyuki、Takahashi Tetsuya、Daida Hiroyuki、Minamino Tohru
  • Journal Title: International Heart Journal Volume: 62 Issue: 2 Pages: 230-237
  • DOI: 10.1536/ihj.20-418
  • NAID: 130008007493
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2021-03-30
  • Peer Reviewed / Open Access
• [Journal Article] Insulin resistance and muscle weakness are synergistic risk factors for silent lacunar infarcts: the Bunkyo Health Study (2021)
  • Author(s): Someya Yuki、Tamura Yoshifumi、Kaga Hideyoshi、Sugimoto Daisuke、Kadowaki Satoshi、Suzuki Ruriko、Aoki Shigeki、Hattori Nobutaka、Motoi Yumiko、Shimada Kazunori、Daida Hiroyuki、Ishijima Muneaki、Kaneko Kazuo、Nojiri Shuko、Kawamori Ryuzo、Watada Hirotaka
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 21093-21093
  • DOI: 10.1038/s41598-021-00377-5
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between skin autofluorescence levels and clinical events in patients with heart failure undergoing cardiac rehabilitation (2021)
  • Author(s): Kunimoto Mitsuhiro、Yokoyama Miho、Shimada Kazunori、Matsubara Tomomi、Aikawa Tatsuro、Ouchi Shohei、Fukao Kosuke、Miyazaki Tetsuro、Fujiwara Kei、Abulimiti Abidan、Honzawa Akio、Shimada Akie、Yamamoto Taira、Amano Atsushi、Saitoh Masakazu、Morisawa Tomoyuki、Takahashi Tetsuya、Daida Hiroyuki、Minamino Tohru
  • Journal Title: Cardiovascular Diabetology Volume: 20 Issue: 1 Pages: 208-208
  • DOI: 10.1186/s12933-021-01398-0
  • Peer Reviewed / Open Access
• [Journal Article] Blocking of interleukin-1 suppresses angiotensin II-induced renal injury (2021)
  • Author(s): Akita Koji、Isoda Kikuo、Ohtomo Fumie、Isobe Sarasa、Niida Tomiharu、Sato-Okabayashi Yayoi、Sano Motoaki、Shimada Kazunori、Iwakura Yoichiro、Minamino Tohru
  • Journal Title: Clinical Science Volume: 135 Issue: 17 Pages: 2035-2048
  • DOI: 10.1042/cs20201406
  • Peer Reviewed
• [Journal Article] Association of phase angle with hospital-acquired functional decline in older patients undergoing cardiovascular surgery (2021)
  • Author(s): Morisawa Tomoyuki、Saitoh Masakazu、Takahashi Tetsuya、Watanabe Hidetaka、Mochizuki Masamichi、Kitahara Eriko、Fujiwara Toshiyuki、Fujiwara Kei、Nishitani-Yokoyama Miho、Minamino Tohru、Shimada Kazunori、Honzawa Akio、Shimada Akie、Yamamoto Taira、Asai Tohru、Amano Atsushi、Daida Hiroyuki
  • Journal Title: Nutrition Volume: 91-92 Pages: 111402-111402
  • DOI: 10.1016/j.nut.2021.111402
  • Peer Reviewed / Open Access
• [Journal Article] Association Between Constipation and Frailty Components in Patients Undergoing Late Phase II Cardiac Rehabilitation (2021)
  • Author(s): Nishitani-Yokoyama Miho、Shimada Kazunori、Yamada Miki、Honzawa Akio、Kunimoto Mitsuhiro、Sugita Yurina、Fujiwara Kei、Matsubara Tomomi、Matsumori Rie、Abulimiti Abidan、Shimada Akie、Yamamoto Taira、Asai Tohru、Amano Atsushi、Saitoh Masakazu、Morisawa Tomoyuki、Takahashi Tetsuya、Daida Hiroyuki、Minamino Tohru
  • Journal Title: Cardiology Research Volume: 12 Issue: 3 Pages: 169-176
  • DOI: 10.14740/cr1246
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of peak oxygen uptake and heart rate reserve in patients after off‐pump coronary artery bypass grafting (2021)
  • Author(s): Abulimiti A、Nishitani‐Yokoyama M、Shimada K、Kunimoto M、Matsubara T、Fujiwara K、Aikawa T、Ouchi S、Sugita Y、Fukao K、Kadoguchi T、Miyazaki T、Shimada A、Yamamoto T、Takahashi T、Fujiwara T、Asai T、Amano A、Daida H、Minamino T.
  • Journal Title: Clinical Cardiology Volume: 44 Issue: 4 Pages: 580-587
  • DOI: 10.1002/clc.23579
  • Peer Reviewed / Open Access
• [Journal Article] Association between constipation and frailty components in patients undergoing late phase II cardiac rehabilitation (2021)
  • Author(s): Nishitani-Yokoyama M, Shimada K, Yamada M, Honzawa A, Kunimoto M, Sugita Y, Fujiwara K, Matsubara T, Matsumori R, Abulimiti A, Shimada A, Yamamoto T, Asai T, Amano A, Saitoh M, Morisawa T, Takahashi T, Daida H, Minamino T.
  • Journal Title: Cardiol Res Volume: in press
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Phase II Comprehensive Cardiac Rehabilitation on Risk Factor Modification and Exercise Capacity in Patients With Acute Coronary Syndrome ― Results From the JACR Registry ― (2020)
  • Author(s): Nishitani-Yokoyama M, Daida H, Shimada K, Ushijima A, Kida K, Kono Y, Sakata Y, Nagayama M, Furukawa Y, Fukuma N, Saku K, Miura SI, Ohya Y, Goto Y, Makita S; Japanese Association of Cardiac Rehabilitation (JACR) Registration Committee.
  • Journal Title: Circulation Reports Volume: 2 Issue: 12 Pages: 715-721
  • DOI: 10.1253/circrep.CR-20-0087
  • NAID: 130007953450
  • ISSN: 2434-0790
  • Year and Date: 2020-12-10
  • Peer Reviewed / Open Access
• [Journal Article] Loss of Skeletal Muscle Mass and Poor Prognosis in Patients with ST-Segment Elevation Myocardial Infarction: Underling Mechanisms and Therapeutic Strategies (2020)
  • Author(s): Shimada Kazunori
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 27 Issue: 12 Pages: 1257-1260
  • DOI: 10.5551/jat.ED135
  • NAID: 130007948671
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2020-12-01
  • Peer Reviewed / Open Access
• [Journal Article] Voluntary exercise and cardiac remodeling in a myocardial infarction model (2020)
  • Author(s): Shahi Hamad Al、Kadoguchi Tomoyasu、Shimada Kazunori、Fukao Kosuke、Matsushita Satoshi、Aikawa Tatsuro、Ouchi Shohei、Shiozawa Tomoyuki、Takahashi Shuhei、Sato-Okabayashi Yayoi、Akita Koji、Isoda Kikuo、Miyazaki Tetsuro、Daida Hiroyuki
  • Journal Title: Open Medicine Volume: 15 Issue: 1 Pages: 545-555
  • DOI: 10.1515/med-2020-0109
  • Peer Reviewed / Open Access
• [Journal Article] Relationship Between Kihon Checklist Score and Anxiety Levels in Elderly Patients Undergoing Early Phase II Cardiac Rehabilitation (2020)
  • Author(s): Honzawa A, Nishitani-Yokoyama M, Shimada K, Kunimoto M, Yamada M, Matsubara T, Matsumori R, Fujiwara K, Abulimiti A, Aikawa T, Ouchi S, Shimizu M, Sugita Y, Shimada A, Yamamoto T, Amano A, Asai T, Saito M, Morisawa T, Takahashi T, Fujiwara T, Daida H, Minamino T.
  • Journal Title: Cardiology Research Volume: 11 Issue: 6 Pages: 405-411
  • DOI: 10.14740/cr1165
  • Peer Reviewed / Open Access
• [Journal Article] Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome (2020)
  • Author(s): Nishitani-Yokoyama Miho、Miyauchi Katsumi、Shimada Kazunori、Yokoyama Takayuki、Ouchi Shohei、Aikawa Tatsuro、Kunimoto Mitsuhiro、Yamada Miki、Honzawa Akio、Okazaki Shinya、Tsujita Hiroaki、Koba Shinji、Daida Hiroyuki
  • Journal Title: Journal of Clinical Medicine Volume: 9 Issue: 5 Pages: 1578-1578
  • DOI: 10.3390/jcm9051578
  • Peer Reviewed / Open Access
• [Journal Article] Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients (2020)
  • Author(s): Kunimoto Mitsuhiro、Shimada Kazunori、Yokoyama Miho、Matsubara Tomomi、Aikawa Tatsuro、Ouchi Shohei、Shimizu Megumi、Fukao Kosuke、Miyazaki Tetsuro、Kadoguchi Tomoyasu、Fujiwara Kei、Abulimiti Abidan、Honzawa Akio、Yamada Miki、Shimada Akie、Yamamoto Taira、Asai Tohru、Amano Atsushi、Smit Andries J.、Daida Hiroyuki
  • Journal Title: BMC Cardiovascular Disorders Volume: 20 Issue: 1 Pages: 195-195
  • DOI: 10.1186/s12872-020-01484-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between the ratio of serum n-3 to n-6 polyunsaturated fatty acids and acute coronary syndrome in non-obese patients with coronary risk factor: a multicenter cross-sectional study (2020)
  • Author(s): Nishizaki Yuji、Shimada Kazunori、Tani Shigemasa、Ogawa Takayuki、Ando Jiro、Takahashi Masao、Yamamoto Masato、Shinozaki Tomohiro、Miyazaki Tetsuro、Miyauchi Katsumi、Nagao Ken、Hirayama Atsushi、Yoshimura Michihiro、Komuro Issei、Nagai Ryozo、Daida Hiroyuki
  • Journal Title: BMC Cardiovascular Disorders Volume: 20 Issue: 1 Pages: 160-160
  • DOI: 10.1186/s12872-020-01445-w
  • Peer Reviewed / Open Access
• [Journal Article] A Comprehensive Approach for Preventing Cardiovascular Events During the Olympic and Paralympic Games (2020)
  • Author(s): SHIMADA KAZUNORI、FUKUSHIMA YOSHIFUMI、FUKAO KOSUKE、SHIOZAKI MASAYUKI、HIKI MAKOTO、AIHARA KOICHIRO、DAIDA HIROYUKI
  • Journal Title: Juntendo Medical Journal Volume: 66 Issue: Suppl.1 Pages: 38-49
  • DOI: 10.14789/jmj.2020.66.JMJ19-P13
  • NAID: 130007919669
  • ISSN: 2187-9737, 2188-2126
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between the Kihon Checklist and the clinical parameters in patients who participated in cardiac rehabilitation (2019)
  • Author(s): Kunimoto Mitsuhiro、Shimada Kazunori、Yokoyama Miho、Matsubara Tomomi、Aikawa Tatsuro、Ouchi Shohei、Shimizu Megumi、Fukao Kosuke、Miyazaki Tetsuro、Kadoguchi Tomoyasu、Fujiwara Kei、Honzawa Akio、Yamada Miki、Shimada Akie、Yamamoto Taira、Amano Atsushi、Daida Hiroyuki
  • Journal Title: Geriatrics & Gerontology International Volume: 19 Issue: 4 Pages: 287-292
  • DOI: 10.1111/ggi.13617
  • Peer Reviewed / Open Access
• [Journal Article] Associations among circulating levels of follistatin-like 1, clinical parameters, and cardiovascular events in patients undergoing elective percutaneous coronary intervention with drug-eluting stents (2019)
  • Author(s): Aikawa Tatsuro、Shimada Kazunori、Miyauchi Katsumi、Miyazaki Tetsuro、Sai Eiryu、Ouchi Shohei、Kadoguchi Tomoyasu、Kunimoto Mitsuhiro、Joki Yusuke、Dohi Tomotaka、Okazaki Shinya、Isoda Kikuo、Ohashi Koji、Murohara Toyoaki、Ouchi Noriyuki、Daida Hiroyuki
  • Journal Title: PLOS ONE Volume: 14 Issue: 4 Pages: e0216297-e0216297
  • DOI: 10.1371/journal.pone.0216297
  • Peer Reviewed / Open Access
• [Journal Article] Physical activity and long-term prognosis in patients with stable coronary artery disease: How often, how intense, and how long? (2019)
  • Author(s): Shimada Kazunori、Nishitani-Yokoyma Miho、Takahashi Tetsuya、Daida Hiroyuki
  • Journal Title: European Journal of Preventive Cardiology Volume: 27 Issue: 4 Pages: 422-425
  • DOI: 10.1177/2047487319881238
  • Peer Reviewed
• [Journal Article] Lack of IκBNS promotes cholate-containing high-fat diet-induced inflammation and atherogenesis in low-density lipoprotein (LDL) receptor-deficient mice (2019)
  • Author(s): Kitamura Kenichi、Isoda Kikuo、Akita Koji、Miyosawa Katsutoshi、Kadoguchi Tomoyasu、Shimada Kazunori、Daida Hiroyuki
  • Journal Title: IJC Heart & Vasculature Volume: 23 Pages: 100344-100344
  • DOI: 10.1016/j.ijcha.2019.03.004
  • Peer Reviewed / Open Access
• [Journal Article] Triglyceride deposit cardiomyovasculopathy: a rare cardiovascular disorder (2019)
  • Author(s): Li Ming、on behalf of the Japan TGCV study group、Hirano Ken-ichi、Ikeda Yoshihiko、Shimada Kazunori、et al.
  • Journal Title: Orphanet Journal of Rare Diseases Volume: 14 Issue: 1 Pages: 134-134
  • DOI: 10.1186/s13023-019-1087-4
  • Peer Reviewed / Open Access
• [Journal Article] Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study (2019)
  • Author(s): Someya Yuki、Tamura Yoshifumi、Kaga Hideyoshi、Nojiri Shuko、Shimada Kazunori、Daida Hiroyuki、Ishijima Muneaki、Kaneko Kazuo、Aoki Shigeki、Miida Takashi、Hirayama Satoshi、Konishi Seiki、Hattori Nobutaka、Motoi Yumiko、Naito Hisashi、Kawamori Ryuzo、Watada Hirotaka
  • Journal Title: BMJ Open Volume: 9 Issue: 9 Pages: e031584-e031584
  • DOI: 10.1136/bmjopen-2019-031584
  • Peer Reviewed / Open Access
• [Journal Article] Promotion of oxidative stress is associated with mitochondrial dysfunction and muscle atrophy in aging mice (2019)
  • Author(s): Kadoguchi Tomoyasu、Shimada Kazunori、Miyazaki Tetsuro、Kitamura Kenichi、Kunimoto Mitsuhiro、Aikawa Tatsuro、Sugita Yurina、Ouchi Shohei、Shiozawa Tomoyuki、Yokoyama‐Nishitani Miho、Fukao Kosuke、Miyosawa Katsutoshi、Isoda Kikuo、Daida Hiroyuki
  • Journal Title: Geriatrics & Gerontology International Volume: 20 Issue: 1 Pages: 78-84
  • DOI: 10.1111/ggi.13818
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Physical Activity on Coronary Plaque Volume and Components in Acute Coronary Syndrome Patients After Early Phase II Cardiac Rehabilitation (2018)
  • Author(s): Nishitani-Yokoyama Miho、Miyauchi Katsumi、Shimada Kazunori、Yokoyama Takayuki、Ouchi Shohei、Aikawa Tatsuro、Kunimoto Mitsuhiro、Yamada Miki、Honzawa Akio、Okazaki Shinya、Daida Hiroyuki
  • Journal Title: Circulation Journal Volume: 83 Issue: 1 Pages: 101-109
  • DOI: 10.1253/circj.CJ-18-0738
  • NAID: 130007550526
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-12-25
  • Peer Reviewed / Open Access
• [Journal Article] Age Stratification and Impact of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid Ratios in Ischemic Stroke Patients (2018)
  • Author(s): Ueno Y, Tanaka R, Yamashiro K, Miyamoto N, Hira K, Kurita N, Sakurai M, Urabe T, Shimada K, Miyazaki T, Daida H, Hattori N
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 7 Pages: 593-605
  • DOI: 10.5551/jat.40691
  • NAID: 130007386958
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-07-01
  • Peer Reviewed / Open Access
• [Journal Article] Correlation of Nutritional Indices on Admission to the Coronary Intensive Care Unit with the Development of Delirium (2018)
  • Author(s): Sugita Yurina、Miyazaki Tetsuro、Shimada Kazunori、Shimizu Megumi、Kunimoto Mitsuhiro、Ouchi Shohei、Aikawa Tatsuro、Kadoguchi Tomoyasu、Kawaguchi Yuko、Shiozawa Tomoyuki、Takasu Kiyoshi、Hiki Masaru、Takahashi Shuhei、Sumiyoshi Katsuhiko、Iwata Hiroshi、Daida Hiroyuki
  • Journal Title: Nutrients Volume: 10 Issue: 11 Pages: 1712-1712
  • DOI: 10.3390/nu10111712
  • Peer Reviewed / Open Access
• [Journal Article] Association Between Visceral Fat Accumulation and Exercise Tolerance in Non-Obese Subjects Without Diabetes (2018)
  • Author(s): Shioya-Yamada Miki、Shimada Kazunori、Nishitani-Yokoyama Miho、Sai Eiryu、Takeno Kageumi、Tamura Yoshifumi、Watada Hirotaka、Kawamori Ryuzo、Daida Hiroyuki、Kawai Sachio
  • Journal Title: Journal of Clinical Medicine Research Volume: 10 Issue: 8 Pages: 630-635
  • DOI: 10.14740/jocmr3403w
  • Peer Reviewed / Open Access
• [Journal Article] Possible Role of NADPH Oxidase 4 in Angiotensin II-Induced Muscle Wasting in Mice (2018)
  • Author(s): Kadoguchi Tomoyasu、Shimada Kazunori、Koide Hiroshi、Miyazaki Tetsuro、Shiozawa Tomoyuki、Takahashi Shuhei、Aikawa Tatsuro、Ouchi Shohei、Kitamura Kenichi、Sugita Yurina、Hamad Al Shahi、Kunimoto Mitsuhiro、Sato-Okabayashi Yayoi、Akita Koji、Isoda Kikuo、Daida Hiroyuki
  • Journal Title: Frontiers in Physiology Volume: 9 Pages: 1-9
  • DOI: 10.3389/fphys.2018.00340
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic Criteria and Severity Score for Triglyceride Deposit Cardiomyovasculopathy (2018)
  • Author(s): Miyauchi Hideyuki、Hashimoto Chikako、Ikeda Yoshihiko、Li Ming、Nakano Yusuke、Kozawa Junji、Sai Eiryu、Nagasawa Yasuyuki、Sugimura Koichiro、Kinugawa Shintaro、Kawaguchi Katsuhiro、Shimada Kazunori、Ide Tomomi、Amano Tetsuya、Higashi Masahiro、Inaba Tohru、Nakamura Hiroshi、Kobayashi Kunihisa、Hirano Ken-ichi
  • Journal Title: Annals of Nuclear Cardiology Volume: 4 Issue: 1 Pages: 94-100
  • DOI: 10.17996/anc.18-00081
  • NAID: 130007474590
  • ISSN: 2189-3926, 2424-1741
  • Peer Reviewed / Open Access
• [Journal Article] Impact of smoking history on the association between eicosapentaenoic acid to arachidonic acid ratio and acute coronarys: a multicenter cross-sectional study. (2018)
  • Author(s): Nishizaki Y, Shimada K, Tani S, Ogawa T, Ando J, Takahashi M, Yamamoto M, Shinozaki T, Miyazaki M, Miyauchi K, Nagao K, Hirayama A, Yoshimura M, Komuro I, Nagai R, Daida H.
  • Journal Title: Tob. Induc. Dis. Volume: 16 Issue: March Pages: 8-8
  • DOI: 10.18332/tid/84973
  • Peer Reviewed / Open Access
• [Journal Article] Significance of Serum Polyunsaturated Fatty Acid Level Imbalance in Patients with Acute Venous Thromboembolism (2017)
  • Author(s): Hiki M, Miyazaki T, Shimada K, Sugita Y, Shimizu M, Aikawa T, Ouchi S, Shiozawa T, Takasu K, Takahashi S, Takagi A, Miyauchi K, Daida H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 10 Pages: 1016-1022
  • DOI: 10.5551/jat.37424
  • NAID: 130006110246
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Low Docosahexaenoic Acid, Dihomo-Gamma-Linolenic Acid, and Arachidonic Acid Levels Associated with Long-Term Mortality in Patients with Acute Decompensated Heart Failure in Different Nutritional Statuses (2017)
  • Author(s): Shohei Ouchi、Tetsuro Miyazaki、Kazunori Shimada、Yurina Sugita、Megumi Shimizu、Azusa Murata、Takao Kato、Tatsuro Aikawa、Shoko Suda、Tomoyuki Shiozawa、Masaru Hiki、Shuhei Takahashi、Hiroshi Iwata、Takatoshi Kasai、Katsumi Miyauchi、Hiroyuki Daida
  • Journal Title: Nutrients Volume: 9 Issue: 9 Pages: 956-956
  • DOI: 10.3390/nu9090956
  • Peer Reviewed / Open Access
• [Journal Article] Low Serum Levels of EPA are Associated with the Size and Growth Rate of Abdominal Aortic Aneurysm (2017)
  • Author(s): 44.Aikawa T, Miyazaki T, Shimada K, Sugita Y, Shimizu M, Ouchi S, Kadoguchi T, Yokoyama Y, Shiozawa T, Hiki M, Takahashi S, Al Shahi H, Dohi S, Amano A, Daida H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 9 Pages: 912-920
  • DOI: 10.5551/jat.38315
  • NAID: 130006038434
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Decreased circulating dihomo-gamma-linolenic acid levels are associated with total mortality in patients with acute cardiovascular disease and acute decompensated heart failure (2017)
  • Author(s): Ouchi Shohei、Miyazaki Tetsuro、Shimada Kazunori、Sugita Yurina、Shimizu Megumi、Murata Azusa、Kato Takao、Aikawa Tatsuro、Suda Shoko、Shiozawa Tomoyuki、Hiki Masaru、Takahashi Shuhei、Kasai Takatoshi、Miyauchi Katsumi、Daida Hiroyuki
  • Journal Title: Lipids in Health and Disease Volume: 16 Issue: 1 Pages: 150-150
  • DOI: 10.1186/s12944-017-0542-2
  • Peer Reviewed / Open Access
• [Journal Article] Left Atrial Appendage Volume and Plasma Docosahexaenoic Acid Levels Are Associated With Atrial Fibrillation Recurrence After Catheter Ablation (2017)
  • Author(s): Shiozawa Tomoyuki、Shimada Kazunori、Sekita Gaku、Hayashi Hidemori、Tabuchi Haruna、Miura Seiji、Fujimoto Shinichiro、Kadoguchi Tomoyasu、Ouchi Shohei、Aikawa Tatsuro、Al Shahi Hamad、Takahashi Shuhei、Miyazaki Tetsuro、Sumiyoshi Masataka、Nakazato Yuji、Daida Hiroyuki
  • Journal Title: Cardiology Research Volume: 8 Issue: 3 Pages: 96-104
  • DOI: 10.14740/cr542w
  • Peer Reviewed / Open Access
• [Journal Article] The balance of omega-3 polyunsaturated fatty acids for reducing residual risks in patients with coronary artery disease. (2017)
  • Author(s): Nishizaki Y, Shimada K, Daida H.
  • Journal Title: Acta Cardiol. Volume: 72 Issue: 3 Pages: 240-248
  • DOI: 10.1080/00015385.2017.1305174
  • Peer Reviewed / Open Access
• [Presentation] 心臓リハビリテーション学会レジストリー研究（The Japanese Association of Cardiac Rehabilitation Registry: J-CARRY study）の進捗状況および今後の展望について (2022)
  • Author(s): 横山美帆, 島田和典, 代田浩之, 福間長知, 大屋祐輔, 三浦伸一郎, 牛島明子, 木田圭亮, 坂田泰彦, 長山雅俊, 古川裕, 三浦正暢, 伊東秀崇, 後藤葉一, 牧田茂.
  • Organizer: 第28回日本心臓リハビリテーション学会学術集会
• [Presentation] 末梢動脈疾患患者の心臓リハビリテーション実施における運動機能と歩行障害質問票との関連 (2022)
  • Author(s): 佐藤優成, 横山美帆, 本沢晶雄, 土井麻弓, 西村潤也, 安澤佳樹, 河原香奈, 島和典, 松森理枝, 須田翔子, 粕谷宏樹, 藤原圭, 國本充洋, Abidan Abulimiti, Jianying Xu, 代田浩之, 佐藤裕之, 南野徹.
  • Organizer: 第28回日本心臓リハビリテーション学会学術集会
• [Presentation] 心臓リハビリテーション維持期における高強度インターバルトレーニングが身体に与える影響 (2022)
  • Author(s): 西村潤也, 深尾宏祐, 川久保沙紀, 染谷由希, 横山美帆, 松森理枝, 島田和典, 本沢晶雄, 土井麻弓, 佐藤優成, 河原香奈, 佐藤裕之, 浅井徹, 天野篤, 代田浩之, 南野徹.
  • Organizer: 第28回日本心臓リハビリテーション学会学術集会
• [Presentation] 持期心臓リハビリテーションにおけるアミノ酸量を考慮した栄養指導による骨格筋量への効果 (2022)
  • Author(s): 川久保沙紀, 深尾宏祐, 西村潤也, 染谷由希, 横山美帆, 松森理枝, 島田和典, 本沢晶雄, 土井麻弓, 佐藤優成, 河原香奈, 佐藤裕之, 浅井徹, 天野篤, 田端実, 代田浩之, 南野徹.
  • Organizer: 第28回日本心臓リハビリテーション学会学術集会
• [Presentation] 心臓リハビリテーションの地域連携を通して健康関連QOLの改善が得られた壮年期心不全 の一例 (2022)
  • Author(s): 粕谷宏樹, 横山美帆, 島田和典, 松森理枝, 藤原圭, Abulimiti Abidan, 徐建影, 本沢晶雄, 土井麻弓, 佐藤優成, 西村潤也, 齊藤美和, 海老名一世, 南野徹.
  • Organizer: 第28回日本心臓リハビリテーション学会学術集会
• [Presentation] 急性冠症候群患者の冠動脈プラーク退縮における身体活動の抗炎症効果の検討 (2021)
  • Author(s): 横山美帆, 宮内克己, 島田和典, 横山貴之, 岡崎真也, 本沢晶雄, 代田浩之, 南野徹.
  • Organizer: 第53回日本動脈硬化学会総会
• [Presentation] 回復期心臓リハビリテーション患者における簡易栄養状態評価表（MNA）を用いた栄養評価. (2021)
  • Author(s): 野澤洋介,横山美帆, 島田和典, 藤原圭, 本沢晶雄, 河原香奈, 土井麻弓, 國本充洋, 松原友美, 松森理枝, Abidan Abulimiti, 齊藤美和, 海老名一世, 嶋田晶江, 山本平, 浅井徹, 天野篤, 高橋哲也, 代田浩之, 南野徹.
  • Organizer: 第27回日本心臓リハビリテーション学会学術集会
• [Presentation] 心臓リハビリテーション施行患者における前腕および手指の最終糖化産物(AGEs)測定の臨床的有用性 (2021)
  • Author(s): 藤原圭, 横山美帆, 島田和典, 國本充洋, 松原友美, 松森理枝, Abidan Abulimiti1, 本沢晶雄, 嶋田晶江, 山本平, 浅井徹, 天野篤, 森沢知之, 齊藤正和, 高橋哲也, 代田浩之, 南野徹.
  • Organizer: 第27回日本心臓リハビリテーション学会学術集会
• [Presentation] Physical activity and coronary plaque morphology in patients with acute coronary syndrome. (2021)
  • Author(s): Shimada K, Nishitani-Yokoyama M, Miyauchi K, Koba S, Daida H.
  • Organizer: 第27回日本心臓リハビリテーション学会学術集会
• [Presentation] Clinical Usefulness of Measurement of Relationship between AGEs (Advanced Glycation End -products in Forearm and Finger) Skin by measured site and Clinical Background in Patients Undergoing Cardiac Rehabilitation. (2020)
  • Author(s): Fujiwara K, Shimada K, Yokoyama M, Kunimoto M, Yamada M, Honzawa A, Sugita Y, Matsubara T, Matsumori R, Abulimiti , Shimada A, Yamamoto , Asai T, Amano, Fujiwara T, Morisawa T, Takahashi T, Daida H.
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] Association between Constipation and Frailty Components in Patients Undergoing Late Phase II Cardiac Rehabilitation. (2020)
  • Author(s): Yokoyama M, Shimada K, Yamada M, Honzawa A, Kunimoto M, Sugita Y, Matsubara T, Matsumori R, Fujiwara K, Abulimiti A, Shimada A, Yamamoto T, Asai T, Amano A, Fujiwara T, Morisawa T, Takahashi T, Daida H.
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] Clinical Significance of 123I-BMIPP Washout Rate in the Triglyceride Deposit Cardiomyovasculopathy Era for Heart Failure Patients. (2020)
  • Author(s): Aoshima C, Fujimoto, Takamura K, Kawaguchi Y, Kamo Y, Nozaki Y, Takahashi D, Kudo A, Hiki , Kasai T, Shimada K, Tomizawa N, Kumamaru K, Daida H.
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] High Neutrophil-to-lymphocyte Ratio and Cortisol Levels were Associated with Delirium Development in Patients with Acute Cardiovascular Diseases and Heart Failure. (2020)
  • Author(s): Sugita Y, Miyazaki T, Shimada K, Shimizu M, Kunimoto M, Aikawa T, Ouchi S, Kadoguchi T, Kawaguchi Y, Shiozawa T, Hiki M, Takahashi S, Yokoyama M, Iwata H, Daida H.
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] Deficiency of I Κ BNS Activates Cholate-induced Inflammation via TLR4/IL-6/STAT3 Pathway and Promotes Atherogenesis in LDL Receptordeficient Mice. (2020)
  • Author(s): Niida T, Isoda K, Kitamura K, Miyosawa K, Kadoguchi T, Shimada K, Daida H.
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] 心臓血管外科術後患者のSPPB各ドメインの継時的変化の特徴について. (2020)
  • Author(s): 渡邉英孝, 望月正道, 室井典子, 北原エリ子, 森沢知之, 高橋哲也, 藤原俊之, 藤原圭, 松原友美, 横山美帆, 島田和典, 嶋田晶江, 山本平, 浅井徹, 天野篤, 代田浩之.
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] 新たな栄養指標は心房細動の病態進行に関係する. (2020)
  • Author(s): 高野明日香, 岩田洋, 三代沢勝利, 塩澤知之, 石井開, 野崎侑衣, 浅見陽介, 大澤翔太, 田渕晴名, 林英守, 関田学, 島田和典, 代田浩之.
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] 非開心術後心臓リハビリ施行患者における心機能別の動脈硬化指標と運動耐容能との関連 (2020)
  • Author(s): 藤原圭, 島田和典, 國本充洋, 横山美帆, 松原友美, 相川達郎, 大内翔平, 清水めぐみ, 深尾宏祐, 宮崎哲郎, 本沢晶雄, 山田みき, 高橋哲也, 天野篤, 代田浩之.
  • Organizer: 日本成人病(生活習慣病)学会
• [Presentation] Prognostic Impact of Peak Oxygen Uptake and Heart Rate Reserve in Patients After Off-pump Coronary Artery Bypass Grafting. (2019)
  • Author(s): Abulimiti A, Shimada K, Yokoyama M, Kunimoto M, Matsubara T, Fujiwara K, Aikawa T, Ouchi S, Shimizu M, Fukao K, Kadoguchi T, Miyazaki T, Shimada A, Yamamoto T, Takahashi T, Fujiwara T, Amano A, Daida H.
  • Organizer: AHA 2019
  • Int'l Joint Research
• [Presentation] 循環器疾患の発症や進展予防に活かす脂肪酸関連のトピックス (2019)
  • Author(s): 島田和典.
  • Organizer: 第67回日本心臓病学会学術集会
• [Presentation] サルコメアにおける顆粒球コロニー刺激因子受容体の発現とその作用. (2019)
  • Author(s): 林地のぞみ, 赤松和土, 湯浅慎介, 福田恵一, 平澤恵理, 島田和典.
  • Organizer: 日本筋学会学術集会
• [Presentation] 中鎖脂肪酸投与によりBMIPP washout rateと中性脂肪蓄積の改善を認めた中性脂肪蓄積心筋血管症の一例. (2019)
  • Author(s): 相川達郎, 島田和典, 蔡榮龍, 青島千紘, 川口裕子, 高村和久, 比企誠, 横山貴之, 宮崎哲朗, 藤本進一郎, 平野賢一, 代田浩之.
  • Organizer: 中性脂肪学会第3回学術集会
• [Presentation] フレイル構成要素を加えた急性期心臓リハビリテーションプログラムの試用について (2019)
  • Author(s): 渡邉英孝, 望月正道, 室井典子, 北原エリ子, 森沢知之, 高橋哲也, 藤原俊之, 横山美帆, 島田和典, 嶋田晶江, 山本平, 浅井徹, 天野篤, 代田 浩之.
  • Organizer: 第 67回日本心臓病学会学術集会抄録
• [Presentation] フレイル心不全患者に対する機能的運動療法の実際. (2019)
  • Author(s): 高橋哲也, 渡邉英孝, 望月正道, 森沢知之, 横山美帆, 島田和典, 藤原俊之, 代田浩之.
  • Organizer: 第 67回日本心臓病学会学術集会抄録
• [Presentation] Lack of IkBNS promotes cholate-containing high-fat diet-induced inflammation and atherogenesis in low-density lipoprotein (LDL) receptor-deficient mice. (2019)
  • Author(s): Kitamura K, Isoda K, Akita K, Miyosawa K, Kadoguchi T, Shimada K, Daida H.
  • Organizer: ESC Congress 2019
  • Int'l Joint Research
• [Presentation] Relationship between skin autofluorescence levels and clinical outcomes in heart failure patients undergoing cardiac rehabilitation. (2019)
  • Author(s): Kunimoto M, Shimada K, Yokoyama M, Honzawa A, Yamada M, Matsubara T, Fukao K, Kadoguchi T, Fujiwara K, Miyazaki T, Yamamoto T, Takahashi T, Fujiwara T, Amano A, Daida H.
  • Organizer: ESC Congress 2019
  • Int'l Joint Research
• [Presentation] Voluntary exercise associated with myokine production ameliorates cardiac remodeling and inflammation in a myocardial infarction mouse model. (2019)
  • Author(s): Kadoguchi T, Shimada K, Hamad A, Aikawa T, Ouchi S, Kitamura K, Kunimoto M, Fukao K, Yokoyama M, Sugita Y, Shiozawa T, Matsushita S, Miyazaki T, Isoda K, Daida H.
  • Organizer: ESC Congress 2019
  • Int'l Joint Research
• [Presentation] Associations between ectopic fat accumulations and cardio-metabolic factors in apparently healthy subjects: assessed by 1H-magnetic resonance spectroscopy in myocardium, liver, and skeletal muscles. (2019)
  • Author(s): Sai E, Shimada K, Yokoyama T, Hiki M, Aikawa T, Ouchi S, Aoshima C, Kawaguchi Y, Miyazaki T, Fujimoto S, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H.
  • Organizer: EuroCMR 2019
• [Presentation] Myocardial triglyceride content and late gadolinium enhancement in patients with hypertrophic cardiomyopathy: Comparison between asymmetric and concentric hypertrophy. (2019)
  • Author(s): Sai E, Shimada K, Yokoyama T, Hiki M, Aikawa T, Aoshima C, Kawaguchi Y, Miyazaki T, Fujimoto S, Aoki S, Daida H.
  • Organizer: EuroCMR 2019
• [Presentation] Arterial stiffness index and exercise tolerance in patients undergoing cardiac rehabilitation: comparison between patients with preserved and reduced ejection fraction. (2019)
  • Author(s): Fujiwara K, Shimada K, Kunimoto M, Yokoyama M, Matsubara T, Aikawa T, Ouchi S, Shimizu M, Fukao K, Miyazaki T, Honzawa A, Yamada M, Amano A, Daida H.
  • Organizer: ESC Preventive Cardiology (Formerly EuroPrevent) 2019
• [Presentation] Relationship between tissue accumulation of advanced glycation end products and exercise tolerance in patients who have undergone cardiac rehabilitation. (2019)
  • Author(s): Kunimoto M, Shimada K, Yokoyama M, Matsubara T, Aikawa T, Ouchi S, Shimizu M, Fukao K, Miyazaki T, Kadoguchi T, Fujiwara K, Honzawa A, Yamada M, Shimada A, Yamamoto T, Amano A, Daida H.
  • Organizer: 83th Annual Meeting of JCS
• [Presentation] Malnutrition and high neutrophil to lymphocyte ratio were associated with delirium development in patients with acute cardiovascular disease. (2019)
  • Author(s): Sugita Y, Miyazaki T, Shimada K, Shimizu M, Kunimoto M, Aikawa T, Ouchi S, Kawaguchi Y, Shiozawa T, Hiki M, Takahashi S, Yokoyama M, Iwata H, Daida H.
  • Organizer: 83th Annual Meeting of JCS
• [Presentation] Diagnostic utility of triglyceride deposition measurement in patients with triglyceride deposit cardiomyovasculopathy by proton magnetic resonance spectroscopy. (2019)
  • Author(s): Aikawa T, Shimada k, Sai E, Aoshima C, Kawaguchi Y, Takamura K, Hiki M, Yokoyama T, Miyazaki T, Fujimoto S, Daida H.
  • Organizer: 83th Annual Meeting of JCS
• [Presentation] Association between myocardial triglyceride content and cardiac function in healthy subjects, endurance athletes, and patients with hypertrophic cardiomyopathy. (2019)
  • Author(s): Shimada K, Sai E, Yokoyama T, Hiki M, Aikawa T, Miyazaki T, Fujimoto S, Daida H.
  • Organizer: 83th Annual Meeting of JCS
• [Presentation] Management of the Residual Risks of Cardiovascular Events: The Importance of Balancing Omega 3Polyunsaturated Fatty Acids in Patients with Cardiovascular Disease. (2019)
  • Author(s): 島田和典, 宮崎哲朗, 西﨑祐史, 代田浩之.
  • Organizer: 83th Annual Meeting of JCS
• [Presentation] Relationship between a novel arterial velocity pulse index and physical function in patients undergoing cardiac rehabilitation: Gender difference analyses. (2019)
  • Author(s): 藤原圭, 島田和典, 横山美帆, 國本充洋, 本沢晶雄, 相川達郎, 大内翔平, 清水めぐみ, 深尾宏祐, 代田浩之.
  • Organizer: 83th Annual Meeting of JCS
• [Presentation] Combined effects of physical activity and achievement of LDL-cholesterol target on coronary plaque volume in patients with acute coronary syndrome. (2019)
  • Author(s): 横山美帆, 宮内克己, 島田和典, 横山貴之, 國本充洋, 大内翔平, 相川達郎, 本沢晶雄, 深尾宏祐, 岡崎真也, 木庭新治, 辻田裕昭, 代田浩之.
  • Organizer: 83th Annual Meeting of JCS
• [Presentation] 本態性高血圧に対する運動指導および運動療法の実際と展望 心臓リハビリテーションにおける高血圧治療と運動療法の役割. (2018)
  • Author(s): 深尾宏祐, 島田和典.
  • Organizer: 第73回日本体力医学会
• [Presentation] 1H-MRS法により心筋内中性脂肪含有量高値を確認した中性脂肪蓄積心筋血管症の4例. (2018)
  • Author(s): 相川達郎, 島田和典, 蔡榮龍, 青島千紘, 川口裕子, 高村和久, 比企誠, 横山貴之, 宮崎哲朗, 藤本進一郎, 代田浩之.
  • Organizer: 日本循環器学会第250回関東甲信越地方会
• [Presentation] 当院における集団心臓リハビリテーションの取り組みー今後の展望と課題ー (2018)
  • Author(s): 山田みき, 横山美帆, 島田和典, 國本充洋, 松原友美, 杉田有里那, 本澤晶雄, 高橋哲也, 代田浩之.
  • Organizer: 日本心臓リハビリテーション学会第3回関東甲信越地方会
• [Presentation] TGCV国際レジストリー. 中性脂肪蓄積心筋血管症（TGCV）研究 10年の歩みと展望. (2018)
  • Author(s): 島田和典.
  • Organizer: 中性脂肪学会第2回学術集会
• [Presentation] 1H-MRS法により心筋内中性脂肪含有量高値を確認した中性脂肪蓄積心筋血管症の6例. (2018)
  • Author(s): 相川達郎, 島田和典, 蔡榮龍, 青島千紘, 川口裕子, 高村和久, 比企誠, 横山貴之, 宮崎哲朗, 藤本進一郎, 代田浩之.
  • Organizer: 中性脂肪学会第2回学術集会
• [Presentation] Malnutrition and Low Omega 6 Pufa Levels on Admission Affect the Development of Delirium in Patients With Acute Cardiovascular Disease Admitted to Coronary Care Unit. (2018)
  • Author(s): Sugita Y, Miyazaki T, Shimada K, Shimizu M, Kunimoto M, Aikawa T, Ouchi S, Kadoguchi T, Kawaguchi Y, Shiozawa T, Takasu K, Hiki M, Takahashi S, Yokoyama M, Iwata H, Daida H.
  • Organizer: American Heart Association Scientific Session 2018.
  • Int'l Joint Research
• [Presentation] Relationship between arterial stiffness index and exercise tolerance in cardiac rehabilitation patients with preserved vs. reduced ejection fraction. (2018)
  • Author(s): Kunimoto M, Shimada K, Yokoyama M, Matsubara T, Aikawa T, Ouchi S, Shimizu M, Fukao K, Fujiwara K, Miyazaki T, Honzawa A, Yamada M, Amano A, Daida H.
  • Organizer: 第22回日本心不全学会学術集会
• [Presentation] 非サルコペニア男性患者における抑うつ症状の運動耐容能への影響. (2018)
  • Author(s): 國本充洋, 島田和典, 横山美帆, 本沢晶雄, 松原友美, 相川達郎, 大内翔平, 杉田有里那, 深尾宏祐, 藤原圭, 宮崎哲朗, 嶋田晶江, 山本平, 天野篤, 代田浩之.
  • Organizer: 第66回日本心臓病学会学術集会
• [Presentation] 急性冠症候群における前期回復期心臓リハビリテーション後の身体活動と健康関連QOLの検討. (2018)
  • Author(s): 横山美帆, 島田和典, 國本充洋, 本沢晶雄, 相川達郎, 大内翔平, 杉田有里那, 藤原圭, 深尾宏祐, 代田浩之.
  • Organizer: 第66回日本心臓病学会学術集会
• [Presentation] Association between tissue accumulation of advanced glycation end products and exercise tolerance in patients who have undergone cardiac rehabilitation. (2018)
  • Author(s): Kunimoto M, Shimada K, Yokoyama M, Aikawa T, Ouchi S, Shimizu M, Fukao K, Miyazaki T, Fujiwra K, Honzawa A, Yamada M, Shimada A, Yamamoto T, Amano A, Daida H.
  • Organizer: ESC Congress 2018
  • Int'l Joint Research
• [Presentation] Malnutrition and low omega 6 PUFA levels on admission were associated with the development of delirium in patients with acute cardiovascular disease admitted to coronary care unit. (2018)
  • Author(s): Sugita Y, Miyazaki T, Shimizu M, Kunimoto M, Aikawa T, Ouchi S, T Kadoguchi T, Kawaguchi Y, Shiozawa T, Takahashi S, Hiki M, Yokoyama M, Iwata H, Shimada K, Daida H.
  • Organizer: ESC Congress 2018
  • Int'l Joint Research
• [Presentation] Angiotensin II-dependent activation of NADPH oxidase 4 contributes to muscle wasting in mice via downregulation of NF-E2-related factor 2. (2018)
  • Author(s): Kadoguchi T, Shimada K, Miyazaki T, Aikawa T, Ouchi S, Kitamura K, Kunimoto M, Sugita Y, Shiozawa T, Isoda K, Daida H.
  • Organizer: ESC Congress 2018
  • Int'l Joint Research
• [Presentation] Low serum vitamin D levels are associated with polyunsaturated fatty acids, inflammation and long-term mortality in patients with acute cardiovascular disease. (2018)
  • Author(s): Aikawa T, Miyazaki T, Shimada K, Sugita Y, Kitamura K, Kunimoto M, Shimizu M, Ouchi S, Shiozawa T, Kadoguchi T, Hiki M, Takahashi S, Daida H.
  • Organizer: ESC Congress 2018
  • Int'l Joint Research
• [Presentation] Aggressive lipid management for cardiovascular risk reduction. (2018)
  • Author(s): Shimada K.
  • Organizer: 23rd Annual Meeting of the International Society of Cardiovascular Pharmacotherapy (ISCP2018)
  • Int'l Joint Research
• [Presentation] Omega-6 polyunsaturated fatty acid levels and delirium in patients with acute cardiovascular disease. (2018)
  • Author(s): Sugita Y, Miyazaki T, Shimizu M, Ouchi S, Aikawa T, Kadoguchi T, Kawaguchi Y, Shiozawa T, Takahashi S, Iwata H, Shimada K, Daida H.
  • Organizer: 23rd Annual Meeting of the International Society of Cardiovascular Pharmacotherapy (ISCP2018)
  • Int'l Joint Research
• [Presentation] Clinical usefulness of the Kihon checklist for frailty and exercise tolerance in patients undergoing cardiac rehabilitation. (2018)
  • Author(s): Kunimoto M, Shimada K, Yokoyama M, Matsubara T, Aikawa T, Ouchi S, Shimizu M, Fukao K, Fujiwara K, Miyazaki T, Honzawa A, Shimada A, Yamamoto T, Amano A, Daida H.
  • Organizer: EuroPREVENT 2018
  • Int'l Joint Research
• [Presentation] Association of low omega-6 polyunsaturated fatty acid levels on admission with delirium in Coronary Care Unit. (2018)
  • Author(s): Sugita Y, Miyazaki T, Shimizu M, Ouchi S, Aikawa T, Kadoguchi T, Kawaguchi Y, Shiozawa T, Takahashi S, Iwata H, Shimada K, Daida H.
  • Organizer: 82th Annual Meeting of JCS,
• [Presentation] Circulating levels of follistatin-like 1 are associated with cardiovascular events in patients undergoing elective percutaneous coronary intervention with drug-eluting stents. (2018)
  • Author(s): Aikawa T, Shimada K, Miyauchi K, Miyazaki T, Tsai R, Ouchi S, Kadoguchi T, Kunimoto M, Joki Y, Dohi T, Okazaki S, Isoda K, Ohhashi K, Shibata R, Murohara T, Ouchi N, Daida H.
  • Organizer: 82th Annual Meeting of JCS,
• [Presentation] Relationship between the Kihon Checklist as an index of frailty and exercise tolerance in patients undergoing cardiac rehabilitation. (2018)
  • Author(s): Kunimoto M, Shimada K, Yokoyama M, Matsubara T, Aikawa T, Ouchi S, Shimizu M, Fukao K, Miyazaki T, Honzawa A, Shimada A, Yamamoto T, Amano A, Daida H.
  • Organizer: 82th Annual Meeting of JCS,
• [Presentation] Angiotensin II-induced muscle wasting is regulated by NADPH oxidase 4-derived oxidative stress via NF-E2 related factor 2. (2018)
  • Author(s): 門口智泰、島田和典、宮崎哲朗、塩澤知之、高橋秀平、相川達郎、大内翔平、喜多村健一、杉田有里那、國本充洋、佐藤弥生、磯田菊生、代田浩之.
  • Organizer: 82th Annual Meeting of JCS,
• [Presentation] Impact of physical activity on coronary plaque volume and components in acute coronary syndrome patients after early-Phase II cardiac rehabilitation. (2018)
  • Author(s): 横山美帆、宮内克己、島田和典、横山貴之、國本充洋、大内翔平、相川達郎、清水めぐみ、本沢晶雄、深尾宏祐、岡崎真也、代田浩之.
  • Organizer: 82th Annual Meeting of JCS,
• [Presentation] 高齢心臓リハビリテーション施行患者におけるプレフレイルと不安レベルとの関連. (2018)
  • Author(s): 本沢晶雄、横山美帆、島田和典、國本充洋、相川達郎、大内翔平、清水めぐみ、深尾宏祐、山本平、天野篤、代田浩之.
  • Organizer: 82th Annual Meeting of JCS,
• [Presentation] 高齢心臓リハビリテーション施行患者におけるフレイル判定と血中脂肪酸との関係. (2018)
  • Author(s): 國本 充洋, 島田 和典, 横山 美帆, 松原 友美, 相川 達郎, 大内 翔平, 清水 めぐみ, 深尾 宏祐, 宮崎 哲朗, 本沢 晶雄, 山田 みき, 嶋田 晶江, 山本 平, 天野 篤, 代田 浩之.
  • Organizer: 日本成人病(生活習慣病)学会
• [Presentation] Low preoperative eicosapentaenoic acid levels predict a new onset of deep vein thrombosis after total knee arthroplasty. (2017)
  • Author(s): Shimizu M, Miyazaki T, Shiozawa J, Sugita Y, Aikawa T, Ouchi S, Hiki M, Kaneko H, Nagayama M, Ishijima M, Shimada K, Kaneko K, Daida H.
  • Organizer: American Heart Association Scientific Session 2017.
  • Int'l Joint Research
• [Presentation] Low polyunsaturated fatty acids levels predict long-term mortality in patients with acute decompensated heart failure independent of the geriatric nutritional risk index. (2017)
  • Author(s): Ouchi S, Miyazaki T, Shimada K, Sugita Y, Shimizu M, Kato T, Aikawa T, Suda S, Hiki M, Takahashi S, Iwata H, Kasai T, Miyauchi K, Daida H.
  • Organizer: American Heart Association Scientific Session 2017.
  • Int'l Joint Research
• [Presentation] Deficiency of NADPH Oxidase 4 Restores Muscle Atrophy via Redox Regulation in Angiotensin II-Infusion Mice. (2017)
  • Author(s): Kadoguchi T, Shimada K, Kunimoto M, Miyazaki T, Daida H.
  • Organizer: 3rd Congress, International Academy of Sportology
  • Int'l Joint Research
• [Presentation] Relationship between the Japanese national checklist as an index of frailty and plasma fatty acid levels in elderly patients receiving cardiac rehabilitation. (2017)
  • Author(s): Kunimoto M, Shimada K, Yokoyama M, Takahashi S, Shiozawa T, Aikawa T, Ouchi S, Amano A, Daida H.
  • Organizer: 3rd Congress, International Academy of Sportology
  • Int'l Joint Research
• [Presentation] 当院における心不全退院前カンファレンスの立ち上げと心不全チーム医療の実際. (2017)
  • Author(s): 横山美帆, 島田和典, 葛西隆敏, 加藤隆生, 比企優, 國本充洋, 山田みき, 本沢晶雄, 渡邉英孝, 代田浩之.
  • Organizer: 第21回心不全学会
• [Presentation] 急性心不全患者の予後における量栄養素の重要性. (2017)
  • Author(s): 宮崎 哲朗, 島田 和典, 大内 翔平, 相川 達郎, 清水 めぐみ, 高橋 秀平, 代田 浩之.
  • Organizer: 日本臨床生理学会
• [Presentation] 高齢心臓リハビリテーション施行患者における基本チェックリストスコアと不安レベルとの関連. (2017)
  • Author(s): 本沢晶雄, 横山美帆, 島田和典, 山田みき、松原友美、相川達郎、大内翔平、清水めぐみ、國本充洋、深尾宏祐、岩田洋、宮崎哲朗, 嶋田晶江, 山本平, 天野篤, 代田浩之.
  • Organizer: 第65回日本心臓病学会学術集会
• [Presentation] Vitamin D低値はomega-3脂肪酸および炎症と関連し急性心疾患患者の長期予後に影響する. (2017)
  • Author(s): 相川達郎, 宮崎哲朗, 杉田有里那, 國本充洋, 清水めぐみ, 大内翔平, 門口智泰, 塩澤知之, 比企優, 高橋秀平, 島田和典, 代田浩之.
  • Organizer: 第65回日本心臓病学会学術集会
• [Presentation] 急性心不全患者の長期予後に対するGNRIと多価不飽和脂肪酸の臨床的意義の検討. (2017)
  • Author(s): 大内翔平, 宮﨑哲朗, 島田和典, 杉田有里那, 清水めぐみ, 村田梓, 加藤隆生, 相川達郎, 須田翔子, 塩澤知之, 比企優, 高橋秀平, 葛西隆敏, 岩田洋, 宮内克己, 代田浩之.
  • Organizer: 第65回日本心臓病学会学術集会
• [Presentation] 高齢心臓リハビリテーション患者における「基本チェックリスト」を用いたフレイル判定と血中脂肪酸との関係. (2017)
  • Author(s): 國本充洋, 島田和典, 横山美帆, 本沢晶雄, 山田みき, 松原友美, 相川達郎, 大内翔平, 清水めぐみ, 深尾宏祐, 宮崎哲朗, 嶋田晶江, 山本平, 天野篤, 代田浩之.
  • Organizer: 第65回日本心臓病学会学術集会
• [Presentation] 慢性心不全患者における心不全手帳の有用性. (2017)
  • Author(s): 桑原瑛里, 横山美帆, 深山直実, 盛光昭子, 武藤香, 山田みき, 本沢晶雄, 松原友美, 深尾宏祐, 相川達郎, 大内翔平, 清水めぐみ, 國本充洋 島田和典, 代田浩之.
  • Organizer: 日本心臓リハビリテーション学会第2回関東甲信越支部地方会
• [Presentation] 1H-MRS法により心筋内中性脂肪含有量の高値を確認した中性脂肪蓄積心筋血管症の一例. (2017)
  • Author(s): 蔡榮龍, 島田和典, 相川達郎, 比企誠, 横山貴之, 宮崎哲朗, 代田浩之.
  • Organizer: 中性脂肪学会第1回学術集会
• [Presentation] NADPH oxidase 4 induces muscle wasting via regulation of NF-E2-related factor 2 in angiotensin ii-infusion mice. (2017)
  • Author(s): Kadoguchi T, Shimada K, Shiozawa T, Takahashi S, Hamad A, Aikawa T, Ouchi S, Kitamura K, Sugita Y, Miyazaki T, AkitaK, Isoda K, Daida H.
  • Organizer: ESC Congress 2017.
  • Int'l Joint Research
• [Presentation] Locomotive症候群において多価不飽和脂肪酸は無症候性深部静脈血栓症に関連する. (2017)
  • Author(s): 清水めぐみ, 宮崎哲朗, 塩澤淳, 杉田有里那, 相川達郎, 大内翔平, 比企優, 金子晴香, 永山正隆, 石島旨章, 島田和典, 金子和夫, 代田浩之.
  • Organizer: 第49回日本動脈硬化学会総会
• [Presentation] 心血管イベント高リスク患者における新たな脂質低下療法の選択肢. (2017)
  • Author(s): 島田和典.
  • Organizer: 第3回J-ISCP学術集会.
• [Presentation] Usefulness of measuring infarct size for predicting post-infarct left ventricular remodeling using cardiac magnetic resonance. (2017)
  • Author(s): Aikawa T, Yokoyama T, Hiki M, Sai E, Kawaguchi Y, Ouchi S, Takamura T, Fujimoto S, Miyazaki T, Shimada K, Daida D.
  • Organizer: EuroCMR 2017.
  • Int'l Joint Research
• [Presentation] Validity of the Japan's national checklist as an index of frailty and plasma fatty acid levels in elderly patients receiving cardiac rehabilitation. (2017)
  • Author(s): Kunimoto M, Shimada K, Yokoyama M, Hoshino Y, Takahashi T, Shiozawa T, Aikawa T, Ouchi S, Amano A, Daida H.
  • Organizer: EuroPREVENT 2016.
  • Int'l Joint Research
• [Book] スポーツと感染症：今求められる対応力. 臨床スポーツ医学 (2021)
  • Author(s): 島田和典
  • Total Pages: 1
  • Publisher: 文光堂
• [Book] 急性心筋梗塞のリハビリテーション. 今日の治療指針 (2021)
  • Author(s): 島田和典
  • Total Pages: 2
  • Publisher: 医学書院
• [Book] 循環器内科 冠動脈疾患と抗血栓療法CCS患者の抗血栓療法 (2020)
  • Author(s): 大内翔平, 宮崎哲朗, 島田和典.
  • Total Pages: 7
  • Publisher: 科学評論社
• [Book] 臨床スポーツ医学 臓器とスポーツ医学 心臓とスポーツ医学 (2020)
  • Author(s): 塩崎正幸, 福島理文, 深尾宏祐, 島田和典.
  • Total Pages: 6
  • Publisher: 文光堂
• [Book] Medical Science Digest Ω3脂肪酸：過去、現在、未来. (2020)
  • Author(s): 島田和典.
  • Total Pages: 3
  • Publisher: ニューサイエンス社
• [Book] 心臓 スポーツと循環器疾患：Sports Cardiologyのすゝめ. (2020)
  • Author(s): 島田和典.
  • Total Pages: 1
  • Publisher: 公益財団法人日本心臓財団
• [Book] 心不全(第2版)中-最新の基礎・臨床研究の進歩- 非薬物療法 運動療法 レジスタンストレーニング (2019)
  • Author(s): 高橋哲也, 藤原俊之, 横山美帆, 島田和典, 代田浩之
  • Total Pages: 7
  • Publisher: 日本臨牀社
• [Book] 改訂版 健康長寿のためのスポートロジー 運動と心血管疾患（１） (2019)
  • Author(s): 島田和典
  • Total Pages: 17
  • Publisher: NHK出版
• [Book] 改訂版 健康長寿のためのスポートロジー 運動と心血管疾患（２） (2019)
  • Author(s): 島田和典
  • Total Pages: 14
  • Publisher: NHK出版
• [Book] 心不全(第2版)中-最新の基礎・臨床研究の進歩- 非薬物療法 運動療法 レジスタンストレーニング (2019)
  • Author(s): 高橋哲也, 藤原俊之, 横山美帆, 島田和典, 代田浩之.
  • Total Pages: 7
  • Publisher: 日本臨牀社
• [Book] Overuse/Underuseを見逃さないプロのみかたと対処法！ スタチン (2019)
  • Author(s): 藤原圭, 島田和典.
  • Total Pages: 5
  • Publisher: 薬局
• [Book] “DHA? EPA?” (2018)
  • Author(s): 島田和典.
  • Total Pages: 7
  • Publisher: 日本抗加齢医学会雑誌
• [Book] 心血管イベント発症予防のためのNext Step 油と脂と脂肪酸を再考する (2018)
  • Author(s): 島田和典, 西崎祐史, 吉原琢磨, 塩澤知之, 相川達郎, 大内翔平, 國本充洋, 杉田有里那, 門口智泰, 林地のぞみ, 藤原圭, 喜多村健一, 蔡栄龍, 比企誠, 横山美帆, 宮崎哲朗, 代田浩之
  • Total Pages: 5
  • Publisher: 高崎医学
• [Book] 「心不全の心臓リハビリテーション標準プログラム」に準じたリハビリテーションプログラム (2018)
  • Author(s): 高橋哲也, 藤原俊之, 横山美帆, 島田和典, 代田浩之.
  • Total Pages: 8
  • Publisher: Journal of Clinical Rehabilitation
• [Book] 動脈・静脈の疾患（上）最新の診断・治療動向 (2017)
  • Author(s): 島田和典, 和田英樹.
  • Total Pages: 5
  • Publisher: 日本臨牀社