• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a stepwise ordered improvement program considering metabolic flexibility in non-obese patients with type 2 diabetes mellitus

Research Project

Project/Area Number 17K01756
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionThe University of Electro-Communications

Principal Investigator

Ohkawara Kazunori  電気通信大学, 大学院情報理工学研究科, 准教授 (30631270)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords2型糖尿病 / 基質酸化能 / 非肥満体型 / エネルギー代謝 / 2型糖尿病
Outline of Final Research Achievements

The purpose of this study was to investigate metabolic flexibility affected by diet and/or exercise in non-obese patients with type 2 diabetes mellitus. As a result, in terms of substrate oxidation capacity and control of postprandial blood glucose, it is suggested that intakes of relatively high-fat diets is a better strategy in non-obese patients with type 2 diabetes mellitus such as Japanese patients. Furthermore, combination of high-fat diets and exercise could be effective for glycemic control and efficient availability of energy substrate.

Academic Significance and Societal Importance of the Research Achievements

国内外の糖尿病治療ガイドラインにおいて食事療法の主目的は減量に位置づけられており、非肥満タイプに対してそのまま適用することは難しい。日本人に多くみられる非肥満の2型糖尿病患者におけるメタボリックフレキシビリティについて検討した本研究は、国内糖尿病患者の食事療法および運動療法のガイドラインに貢献できるエビデンスの一つに位置付けられる。また近年、アジア諸国における糖尿病患者の増加は著しいことから、日本人だけでなく、欧米人に比べて痩せの傾向にあるアジア人を対象としたガイドラインの提言にもつながると期待している。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (49 results)

All 2020 2019 2018 2017

All Journal Article (8 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (40 results) (of which Int'l Joint Research: 19 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Accuracy of 12 Wearable Devices for Estimating Physical Activity Energy Expenditure Using a Metabolic Chamber and the Doubly Labeled Water Method: A Validation Study.2019

    • Author(s)
      Murakami H, Kawakami R, Nakae S, Yamada Y, Nakata Y, Ohkawara K, Sasai H, Ishikawa-Takata K, Tanaka S, Miyachi M.
    • Journal Title

      JMIR mHealth and uHealth

      Volume: 7 Issue: 8 Pages: e13938-e13938

    • DOI

      10.2196/13938

    • NAID

      120007127814

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of energy expenditure using doubly labeled water, physical activity by accelerometer and reported dietary intake in Japanese men with type 2 diabetes: A preliminary study.2019

    • Author(s)
      Yoshimura E, Ohkawara K, Ishikawa-Takata K, Yamada S, Tokui M, Funae O, Takimoto H, Katsukawa F.
    • Journal Title

      J Diabetes Investig

      Volume: 10(2) Issue: 2 Pages: 318-321

    • DOI

      10.1111/jdi.12921

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of daily physical activities with sensors attached to the upper limbs in healthy adults using a manual wheelchair2018

    • Author(s)
      Takigawa R, Inayama T, Yamada K, Muraoka Y, Ohkawara K
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 7 Issue: 3 Pages: 193-202

    • DOI

      10.7600/jpfsm.7.193

    • NAID

      130006736404

    • ISSN
      2186-8123, 2186-8131
    • Year and Date
      2018-05-25
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 代謝疾患、その他の慢性疾患の運動処方(ACSM運動処方の指針・アップデート)2018

    • Author(s)
      大河原一憲
    • Journal Title

      体育の科学

      Volume: 68(6) Pages: 426-431

    • Related Report
      2018 Research-status Report
  • [Journal Article] 両掌間生体インピーダンス(HHBI)法による日本の子どもの除脂肪量(FFM)推定式の開発2018

    • Author(s)
      溝畑潤、中塘二三生、大河原一憲、金憲経、田中喜代次、田路秀樹
    • Journal Title

      健康支援

      Volume: 20(1) Pages: 9-16

    • NAID

      40021491666

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] ACSMが定義する軽強度・軽運動2018

    • Author(s)
      大河原一憲
    • Journal Title

      体育の科学

      Volume: 68(3) Pages: 165-173

    • Related Report
      2017 Research-status Report
  • [Journal Article] 日本人の子どもの身体組成の推定精度に関する検討‐水中体重秤量法、重水希釈法及びDXAにより求めた除脂肪量から‐2017

    • Author(s)
      溝畑潤、中塘二三生、大河原一憲、金憲経、田中喜代次、田路秀樹
    • Journal Title

      教育医学

      Volume: 62(4) Pages: 411-417

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 座位行動の評価を主な目的とした質問紙「労働者生活行動時間調査票(JNIOSH-WLAQ)」の開発2017

    • Author(s)
      松尾知明,蘇リナ,笹井浩行,大河原一憲
    • Journal Title

      産業衛生学雑誌

      Volume: 59(6) Pages: 219-228

    • NAID

      130006230169

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 日本人高齢者における活動の質的向上を目指した生活活動分類法の提案2020

    • Author(s)
      鈴木美穂、根本亘、大河原一憲
    • Organizer
      第21回日本健康支援学会年次学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高齢者を対象にした運動意欲増進を促すタブレット支援システムの検討2020

    • Author(s)
      都竹涼、坂本一憲、鈴木美穂、根本亘、福田裕司、大河原一憲
    • Organizer
      第21回日本健康支援学会年次学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Acute exercise alters functional connectivity during cognitive task2019

    • Author(s)
      Ando S, Saito S, Mizuguchi N, Sudo M, Ohkawara K, Senoo A
    • Organizer
      The 65th American College of Sports Medicine
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interactional influence of exercise habits and risk factors of metabolic syndrome on medical expenses in Japanese men2019

    • Author(s)
      Okada K, Ohkawara K, Katsukawa F
    • Organizer
      The 24th European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of video viewing not aimed at motivating exercise during ergometer exercise on voluntary exercise duration2019

    • Author(s)
      Shimizu S, Nagashima M, Okada K, Suzuki M, Ando S, Ohkawara K
    • Organizer
      The 24th European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The relationship between objectively measured physical activity and quality of life among school-aged children2019

    • Author(s)
      Okazaki K, Koyama Y, Ohkawara K
    • Organizer
      The 24th European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Alterations in functional connectivity is associated with cognitive improvement induced by acute exercise2019

    • Author(s)
      Saito S, Senoo A, Wang S, Mizuguchi N, Sudo M, Ohkawara K, Ando S
    • Organizer
      The 24th European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of alterations in visual flow on physiological and psychological responses to exercise2019

    • Author(s)
      Ando S, Yasukawa K, Koike Y, Konno T, Sudo M, Ohkawara K
    • Organizer
      The 24th European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高齢者を対象とした機械学習による生活活動分類2019

    • Author(s)
      鈴木美穂、岡田幸樹、清水俊平、大河原一憲
    • Organizer
      第74回日本体力医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ニューラルネットワークによる医療予測モデルと運動習慣の影響2019

    • Author(s)
      岡田幸樹、大河原一憲、鈴木美穂、清水俊平、勝川史憲
    • Organizer
      第74回日本体力医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Does volume of basal ganglia predict cognitive performance at rest and during exercise?2019

    • Author(s)
      Katagiri Y, Senoo A, Tamura T, Wang S, Mizuguchi N, Sudo M, Ohkawara K, Ando S
    • Organizer
      Irago conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acute exercise induces increased arousal level and improves cognitive performance2019

    • Author(s)
      Wang S, Senoo A, Saito S, Sudo M, Ohkawara K, Ando S
    • Organizer
      Irago conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脊髄損傷を有する車椅子使用者の生活活動強度推定に関する予備検討2019

    • Author(s)
      伊藤隆汰、稲山貴代、村岡慶裕、岡純、鶴ヶ野しのぶ、大河原一憲
    • Organizer
      第20回日本健康支援学会年次学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 運動の有能性に着目したサポートが運動教室中の身体活動量に及ぼす影響2019

    • Author(s)
      山崎直輝、瀑布川竜次、坂本一憲、安藤創一、鶴ヶ野しのぶ、大河原一憲
    • Organizer
      第20回日本健康支援学会年次学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 決定木及びランダムフォレストを用いた活動分類に関する論文レビュー2019

    • Author(s)
      鈴木美穂、星野秀彰、大河原一憲
    • Organizer
      第20回日本健康支援学会年次学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高齢者のフレイル予防を目的とした健康づくり支援アプリケーションの開発2019

    • Author(s)
      清水俊平、大河原一憲
    • Organizer
      第20回日本健康支援学会年次学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 運動意欲の促進を意図しない映像視聴が運動持続時間に与える影響2019

    • Author(s)
      永島雅章、伊藤隆汰、山﨑直輝、鈴木美穂、岡田幸樹、清水俊平、安藤創一、大河原一憲
    • Organizer
      第20回日本健康支援学会年次学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ダウン症がある小学生の日常生活における身体活動量の評価2019

    • Author(s)
      山中恵里香、大河原一憲、岡崎勘造、稲山貴代
    • Organizer
      第20回日本健康支援学会年次学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 運動習慣の差による医療費と生活習慣病危険因子の関連について2019

    • Author(s)
      岡田幸樹、大河原一憲、勝川史憲
    • Organizer
      第20回日本健康支援学会年次学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Performance in square stepping exercise is associated with working memory2018

    • Author(s)
      Ando S, Makino R, Takigawa R, Yasukawa K, Kokubu M, Sakamoto K, Tsurugano S, Ohkawara K
    • Organizer
      The 64th American College of Sports Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of daily sedentary time between children engaging in more and less than 2-hour screen time2018

    • Author(s)
      Okazaki K, Koyama Y, Ohkawara K
    • Organizer
      The 23th European College of Sport Science
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 中学生のヘモグロビン推定値と体力、身体活動の関連2018

    • Author(s)
      岡崎勘造、小山雄三、大河原一憲
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 糖尿病患者における医療費に関わる要因探索2018

    • Author(s)
      岡田幸樹、大河原一憲、勝川史憲
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 健康増進を目的とした運動実践支援システムの構築2018

    • Author(s)
      内藤 奏, 大河原 一憲, 山本 佳世子
    • Organizer
      第19回日本健康支援学会年次学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 非肥満 2 型糖尿病患者における高脂肪食摂取後の運動が食欲に及ぼす影響2018

    • Author(s)
      福島稜規、高田和子、勝川史憲、徳井幹也、船江修、山田悟、瀧本秀美、大河原一憲
    • Organizer
      第19回日本健康支援学会年次学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 特定健診データによる糖尿病患者の医療費推定モデルの構築2018

    • Author(s)
      星野秀彰、大河原一憲、勝川史憲
    • Organizer
      第19回日本健康支援学会年次学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 食育イベント体験を通じた食への関心の変化に関する予備調査2018

    • Author(s)
      小池 温子、大河原一憲
    • Organizer
      第19回日本健康支援学会年次学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 高齢者における二重課題運動時の巧緻性と視覚情報の関連2018

    • Author(s)
      瀑布川竜次、國部雅大、安藤創一、牧野諒太、安川巧樹、坂本一憲、鶴ヶ野しのぶ、大河原一憲
    • Organizer
      第19回日本健康支援学会年次学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 運動介入時における2種類の動機づけに基づいたサポートが運動継続に及ぼす影響‐内発的および外発的動機づけ支援の比較‐2018

    • Author(s)
      山﨑直輝、瀑布川竜次、坂本一憲、安藤創一、小林中、鶴ヶ野しのぶ、大河原一憲
    • Organizer
      第19回日本健康支援学会年次学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ダウン症がある小学生の日常生活における身体活動量の評価2018

    • Author(s)
      山中恵里香、大河原一憲、岡崎勘造、稲山貴代
    • Organizer
      第19回日本健康支援学会年次学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Comparing the Effects of intrinsic and extrinsic motivational support on physical activity level during exercise2017

    • Author(s)
      Yamazaki N, Sakamoto K, Ando S, Takigawa R, Kobayashi A, Tsurugano S, Tanaka K, Ohkawara K
    • Organizer
      The 65th American College of Sports Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Variation in daily physical activity during an exercise intervention period in older adult Japanese2017

    • Author(s)
      Takigawa R, Sakamoto K, Ando S, Yamazaki N, Kobayashi A, Tsurugano S, Tanaka K, Ohkawara K
    • Organizer
      The 65th American College of Sports Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Improvement of cognitive function by dual-task exercise2017

    • Author(s)
      Ito R, Ando S, Takigawa R, Sakamoto K, Kobayashi A, Tsurugano S, Tanaka K, Ohkawara K
    • Organizer
      The 65th American College of Sports Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A decision-tree model for classifying physical activity types using a three-axis accelerometer in Japanese adults2017

    • Author(s)
      Hoshino H, Takigawa R, Miyachi M, Murakami H, Tanaka S, Kawakami R, Nakae S, Tanaka K, Ohkawara K
    • Organizer
      The 65th American College of Sports Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reliability and validity of a workers’sitting time questionnaire (JNIOSH-WPAQ) using the percentage method2017

    • Author(s)
      Matsuo T, Sasai S, So R, Ohkawara K
    • Organizer
      The 65th American College of Sports Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of acute aerobic exercise on executive function: an fMRI study2017

    • Author(s)
      Kobayashi A, Senoo A, Fujita G, Mizuguchi N, Kamijo T, Maruyama K, Takigawa R, Ohkawara K, Ando, S
    • Organizer
      The 22th European College of Sport Science
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of aerobic and resistance exercise on cognitive function2017

    • Author(s)
      Komiyama T, Ando K, Sudo M, Takigawa R, Ohkahara K, Uehara Y, Tanaka H, Higaki Y, Ando S
    • Organizer
      The 65th American College of Sports Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationship between self-reported physical activity from the Health Behaviour in School-aged Children instrument and objective daily steps in children2017

    • Author(s)
      Okazaki K, Koyama Y, Ohkawara K
    • Organizer
      The 22th European College of Sport Science
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of a high fat diet followed by an exercise on substrate oxidation and glycemic and ketone body controls in non-obese patients with DMII2017

    • Author(s)
      Fukushima T, Ishikawa-Takata K, Katsukawa F, Tokui M, Funae O, Yamada S, Takimoto H, Ohkawara K
    • Organizer
      4th international conference on Recent Advances and Controversies in Measuring Energy Metabolism
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 2型糖尿病患者の代謝適応と食事・運動療法2017

    • Author(s)
      福島稜規、大河原一憲
    • Organizer
      第36回日本臨床運動療法学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 運動生理学 第6章 身体組成・体格2019

    • Author(s)
      大河原一憲
    • Total Pages
      13
    • Publisher
      羊土社
    • ISBN
      9784758113564
    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi