Development of a stepwise ordered improvement program considering metabolic flexibility in non-obese patients with type 2 diabetes mellitus
| Project/Area Number |
17K01756
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | The University of Electro-Communications |
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Principal Investigator |
Ohkawara Kazunori 電気通信大学, 大学院情報理工学研究科, 准教授 (30631270)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 2型糖尿病 / 基質酸化能 / 非肥満体型 / エネルギー代謝 / ２型糖尿病 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate metabolic flexibility affected by diet and/or exercise in non-obese patients with type 2 diabetes mellitus. As a result, in terms of substrate oxidation capacity and control of postprandial blood glucose, it is suggested that intakes of relatively high-fat diets is a better strategy in non-obese patients with type 2 diabetes mellitus such as Japanese patients. Furthermore, combination of high-fat diets and exercise could be effective for glycemic control and efficient availability of energy substrate.
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| Academic Significance and Societal Importance of the Research Achievements |
国内外の糖尿病治療ガイドラインにおいて食事療法の主目的は減量に位置づけられており、非肥満タイプに対してそのまま適用することは難しい。日本人に多くみられる非肥満の2型糖尿病患者におけるメタボリックフレキシビリティについて検討した本研究は、国内糖尿病患者の食事療法および運動療法のガイドラインに貢献できるエビデンスの一つに位置付けられる。また近年、アジア諸国における糖尿病患者の増加は著しいことから、日本人だけでなく、欧米人に比べて痩せの傾向にあるアジア人を対象としたガイドラインの提言にもつながると期待している。
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Report
(4 results)
Research Products
(49 results)
