| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, based on the BioID enzyme labeling technique using a biotin ligase mutant (BirA), we searched for essential molecules involved in muscle atrophy via heat shock proteins (HSPBs). As a result, we succeeded in identifying several molecules that are included in the cytoprotective function of HSPBs to suppress muscle atrophy caused by endoplasmic reticulum stress. This result suggested cellular stress protection via the Polo-like kinase 2 (PLK2)/HSPB5 pathway in the endoplasmic reticulum stress response of muscle cells.
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