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Central blood pressure wave analysis during dynamic exercise test for the assessment of peripheral vasodilatory function

Research Project

Project/Area Number 17K01861
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionWakayama Medical University

Principal Investigator

Miyai Nobuyuki  和歌山県立医科大学, 保健看護学部, 教授 (40295811)

Co-Investigator(Kenkyū-buntansha) 有田 幹雄  和歌山県立医科大学, 保健看護学部, 名誉教授 (40168018)
宮下 和久  和歌山県立医科大学, 医学部, 教授 (50124889)
森岡 郁晴  和歌山県立医科大学, 保健看護学部, 教授 (70264877)
竹下 達也  和歌山県立医科大学, 医学部, 博士研究員 (20150310)
牟礼 佳苗  和歌山県立医科大学, 医学部, 准教授 (90268491)
寺田 和史  天理大学, 体育学部, 教授 (40454798)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords運動負荷試験 / 中心動脈圧波形 / 血管内皮機能 / 動脈硬化 / 心血管リスク / 心血管疾患 / 循環器・高血圧 / 脈波
Outline of Final Research Achievements

In this study, we have demonstrated that central arterial pressure and the wave reflection parameters measured during dynamic exercise are affected by the exposure to arteriosclerotic risk factors and related to the markers of subclinical vascular impairment. Therefore, the impaired vascular function may have a greater influence on vascular reactivity than on basal tone and hence could be identified by an abnormal response of central arterial pressure to exercise even before clinical manifestation of atherosclerosis. In addition, we have developed a simple and convenient step exercise test to evaluate central arterial pressure waveforms during exercise in medical examinations and large population studies.

Academic Significance and Societal Importance of the Research Achievements

本研究は,運動負荷時の中心動脈圧波形の解析に基づく新しい血管機能評価法を提案するもので,当該分野における研究の進展に寄与するとともに,臨床における中心動脈圧測定の意義や応用範囲を拡げることに繋がるものと思われる.また,今後,簡便な検査法とその評価基準が確立されることで,集団健診などでのスクリーニング検査に適用可能となり,心血管疾患のリスク評価や予防のための健康管理に貢献できると考えられる.

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (17 results)

All 2021 2020 2019 2018 2017

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (14 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] District Differences in the Measured Values of Arterial Stiffness in Japan2021

    • Author(s)
      Miyai N, Uchiba K, Tomiyama H, Matsumoto C, Kinoshita A, Vlachopoulos C, Nilsson P, Arita M
    • Journal Title

      Circulation Reports

      Volume: 3 Issue: 10 Pages: 620-624

    • DOI

      10.1253/circrep.CR-21-0064

    • NAID

      130008102379

    • ISSN
      2434-0790
    • Year and Date
      2021-10-08
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals2020

    • Author(s)
      Miyai Nobuyuki、Shiozaki Maki、Terada Kazufumi、Takeshita Tatsuya、Utsumi Miyoko、Miyashita Kazuhisa、Arita Mikio
    • Journal Title

      Clinical and Experimental Hypertension

      Volume: 43 Issue: 1 Pages: 56-62

    • DOI

      10.1080/10641963.2020.1806292

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Muscle mass reduction, low muscle strength, and their combination are associated with arterial stiffness in community-dwelling elderly population: the Wakayama Study2020

    • Author(s)
      Zhang Yan、Miyai Nobuyuki、Abe Kaori、Utsumi Miyoko、Uematsu Yuji、Terada Kazufumi、Nakatani Toshiaki、Takeshita Tatsuya、Arita Mikio
    • Journal Title

      Journal of Human Hypertension

      Volume: - Issue: 5 Pages: 446-454

    • DOI

      10.1038/s41371-020-0355-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] The association of arterial stiffness with muscle mass reduction and low muscle strength in community-dwelling elderly individuals: the Wakayama study2021

    • Author(s)
      Kawaguchi E, Miyai N, Zhang Y, Hattori S, Uematsu Y, Utsumi M, Takeshita T,Arita M
    • Organizer
      The 89th Congress of European Atherosclerosis Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lower muscle mass is associated with greater arterial stiffness in a graded fashion in community-dwelling elderly individuals: a cross-sectional study.2021

    • Author(s)
      Zhang Y , Fujiyoshi A, Miyai N, Utsumi M, Takeshita T, Uematsu Y, Arita M
    • Organizer
      The 19th International Symposium on Atherosclerosis (ISA2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地域在住中高年者における血清尿酸値と動脈スティフネスの関連2021

    • Author(s)
      中山摩希子,宮井信行,張岩,寒川友起子,早川博子,水越正人,内海みよ子,有田幹雄
    • Organizer
      第9回臨床高血圧フォーラム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 高齢高血圧者における起立性低血圧と骨格筋量の関連2021

    • Author(s)
      木下あずな,宮井信行,寒川友起子,張岩,野上絵理子,内海みよ子,有田幹雄
    • Organizer
      第57回日本循環器病予防学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effects of serum uric acid on skeletal muscle mass in community-dwelling elderly individuals2019

    • Author(s)
      Nakayama M, Miyai N, Hattori S, Utsumi M, Arita M
    • Organizer
      87th Congress of European Atherosclerosis Society
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of smoking and smoking cessation on aortic wave reflection in middle-aged and elderly individuals: the Wakayama Study2019

    • Author(s)
      Miyai N, Nagatomo N, Zhang Y, Abe K, Morishita M, Sougawa Y, Utsumi M, Takeshita T, Miyashita K, Arita M
    • Organizer
      The 29th Scientific Meeting of the European Society of Hypertension and Cardiovascular Protection
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Low skeletal muscle mass is associated with increased arterial stiffness in community-dwelling elderly individuals: the Wakayama Study2019

    • Author(s)
      Zhang Y, Miyai N, Nakayama M, Sakaguchi M, Kawai M, Hattori S, Utsumi M, Takeshita T, Miyashita K, Arita M
    • Organizer
      The 29th Scientific Meeting of the European Society of Hypertension and Cardiovascular Protection
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 過去喫煙者における喫煙量および禁煙後年数が中心動脈圧波形に及ぼす影響2019

    • Author(s)
      宮井信行,長友奈央,阪口将登,牟礼佳苗,水越正人,内海みよ子,竹下達也,有田幹雄
    • Organizer
      第42回日本高血圧学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 地域在住高齢者における動脈スティフネスと骨格筋量減少および筋力低下との関連2019

    • Author(s)
      宮井信行,張岩,辻久美子,寺田和史,中谷敏昭,内海みよ子,竹下達也,宮下和久,有田幹雄
    • Organizer
      第90回日本衛生学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] The combination of renal dysfunction and muscle mass reduction is associated with arterial stiffness in elderly individuals2018

    • Author(s)
      Sakaguchi M, Miyai N, Nagatomo N, Morishita M, Onishi S, Uchikawa Y, Takeshita T, Utsumi M, Shiba M, Arita M
    • Organizer
      The 28th Scientific Meeting of the European Society of Hypertension and Cardiovascular Protection
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 中年期の正常域血圧者における喫煙が運動負荷に伴う中心動脈圧波形の変化に及ぼす影響2018

    • Author(s)
      宮井信行,塩崎万起,長友奈央,寒川友起子,島袋美絵,牟礼佳苗,竹下達也,内海みよ子,宮下和久,有田幹雄
    • Organizer
      第41回日本高血圧学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] The impact of smoking on central aortic pressure response to exercise in middle-aged normotensive individuals2017

    • Author(s)
      Miyai N、 Shiozaki M、 Nagatomo N、 Uchikawa Y、 Terada K、 Tomida K、 Mure K、 Utsumi M、 Takeshita T、 Miyashita K、 Arita M
    • Organizer
      The 27th Scientific Meeting of the European Society of Hypertension and Cardiovascular Protection
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 中高年男性における血圧と喫煙が中心血圧の反射波成分に及ぼす影響2017

    • Author(s)
      長友奈央、宮井信行、森下美佳、岡野友紀子、内川友起子、山本美緒、島袋美絵、牟礼佳苗、内海みよ子、竹下達也、宮下和久、有田幹雄
    • Organizer
      第40回日本高血圧学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 中高年者における中心大動脈の血圧上昇に及ぼす喫煙と食塩摂取量の単独および複合影響2017

    • Author(s)
      長友奈央、宮井信行、内川友起子、森下美佳、大西修平、阪口将登、内海みよ子、竹下達也、宮下和久、有田幹雄
    • Organizer
      第88回日本衛生学会学術集会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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