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Identification of co-sharing endophenotype between parents and children with ADHD characteristics, and its effect on the child's ADHD symptoms (behavioral characteristics).

Research Project

Project/Area Number 17K01891
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Childhood science (childhood environment science)
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Harada Taeko  浜松医科大学, 子どものこころの発達研究センター, 特任助教 (60525963)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords注意欠如・多動症 / 中間表現型 / 実行機能 / コホート研究 / 学童期 / 認知発達 / ADHD / NIRS / 発達 / 認知 / 親子中間表現型 / 認知機能
Outline of Final Research Achievements

In this study, we examined identification of endophenotype of ADHD, as the executive function index measured by a combination of cortical activity and performance of executive tasks, using functional Near-Infrared Spectroscopy (fNIRS). Evaluation of executive functions was assessed in prefrontal and premotor regions using multiple rule management task by fNIRS. The results showed that bilateral prefrontal and premotor cortices are broadly involved in multiple rule management processing. We will examine whether the multiple rule management task can be utilized as a measure of the endophenotype of ADHD in the next study.

Academic Significance and Societal Importance of the Research Achievements

現在まで、実行機能の違いを定型児とADHD児の中間表現型研究により検討されてきたものの、ADHDの遺伝的形質(親子の共有因子)としての中間表現型については未だ検討がなされていない。ADHDの中間表現型における親子間の共有因子の有無や親の潜在的ADHD特性が子の行動特性に与える影響が明らかになれば、中間表現型を考慮した親の行動特性と子のADHD症状による問題行動の予防や対処法など、より効果的なアプローチを見出だすことが可能となり、養育的介入への道筋が期待できる。よって、養育への介入を視野に入れた本研究の意義は大きいと言える。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2021 2020 2019 2018

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Diagnosing Autism Spectrum Disorder Without Expertise: A Pilot Study of 5- to 17-Year-Old Individuals Using Gazefinder2021

    • Author(s)
      Tsuchiya Kenji J.、Hakoshima Shuji、Hara Takeshi、Ninomiya Masaru、Saito Manabu、Fujioka Toru、Kosaka Hirotaka、Hirano Yoshiyuki、Matsuo Muneaki、Kikuchi Mitsuru、Maegaki Yoshihiro、Harada Taeko、Nishimura Tomoko、Katayama Taiichi
    • Journal Title

      Frontiers in Neurology

      Volume: 11 Pages: 603085-603085

    • DOI

      10.3389/fneur.2020.603085

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polygenic risk score analysis revealed shared genetic background in attention deficit hyperactivity disorder and narcolepsy2020

    • Author(s)
      Takahashi Nagahide、Nishimura Tomoko、Harada Taeko、Okumura Akemi、Choi Damee、Iwabuchi Toshiki、Kuwabara Hitoshi、Takagai Shu、Nomura Yoko、Newcorn Jeffrey. H.、Takei Nori、Tsuchiya Kenji J.
    • Journal Title

      Translational Psychiatry

      Volume: 10 Issue: 1 Pages: 284-284

    • DOI

      10.1038/s41398-020-00971-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of Genetic Risks With Autism Spectrum Disorder and Early Neurodevelopmental Delays Among Children Without Intellectual Disability2020

    • Author(s)
      Takahashi Nagahide、Harada Taeko、Nishimura Tomoko、Okumura Akemi、Choi Damee、Iwabuchi Toshiki、Kuwabara Hitoshi、Takagai Shu、Nomura Yoko、Takei Nori、Tsuchiya Kenji J.
    • Journal Title

      JAMA Network Open

      Volume: 3 Issue: 2 Pages: 1921644-1921644

    • DOI

      10.1001/jamanetworkopen.2019.21644

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Developmental trajectory of rule management system in children2018

    • Author(s)
      Harada T, Tsuruno M, Shirokawa T.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 12798-12798

    • DOI

      10.1038/s41598-018-31235-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Contributions of the cerebello-thalamo-cortical system to the processing of multiple rules2019

    • Author(s)
      T. IWABUCHI, T. HARADA, A. SHIGETOMI2 K. J. TSUCHIYA, N. TAKEI
    • Organizer
      SfN's 49th annual meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional organization of the prefrontal and premotor cortices for hierarchical rule management processing2018

    • Author(s)
      Harada T, Iwabuchi T, Tsuchiya KJ, Kuwabara H, Takei N, Hoshi Y
    • Organizer
      fNIRS2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2022-01-27  

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