| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Urine obtained from whole-body gamma-irradiated mice (4 Gy) is analyzed for each fraction by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to identify radiation-responsive moles. We identified two candidates for hepcidin-2 and a peptide fragment of the renal androgen regulatory protein (KAP). The proportion of KAP peptide fragments showed no correlation with radiation dose. Furthermore, the increase in hepcidin-2 after exposure to relatively low doses (0.25 and 0.5 Gy, respectively) was biphasic (at 8-48 and 120-168 hours after irradiation). The increase in hepcidin 2 paralleled the increase in liver hepcidin 2 gene (Hamp2) mRNA levels.
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