Biomembrane shape regulation by proteins
Project/Area Number |
17K05607
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological physics/Chemical physics/Soft matter physics
|
Research Institution | The University of Tokyo |
Principal Investigator |
|
Project Period (FY) |
2017-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 生物物理 / ソフトマター / 生体膜 / シミュレーション |
Outline of Final Research Achievements |
Shape transformations of biomembranes were studied by using coarse-grained simulations. We clarified (1) the importance of chirality in membrane tubulation, (2) traveling waves and Turing patterns with coupling with membrane deformation, and (3) non-equilibrium fluctuations of moving membrane by filament growth. We also developed (4) virtual bending method to calculate membrane mechanical properties and (5) how to maintain the angular-momentum conservation at the discretization of Navier-Storks equations.
|
Academic Significance and Societal Importance of the Research Achievements |
細胞内の生命活動における静的や動的な膜構造はタンパク質によって制御されている。これらのタンパク質の欠損は細胞小器官の構造異常や細胞機能不全につながり、その機能を理解することは非常に重要である。しかし、その機構はまだよく理解されていない。本研究では分子レベルから、マイクロメートルのスケールの様々の状況で、タンパク質がどのように生体膜と相互作用し、構造を制御しているかについて重要な知見を明らかにした。
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Report
(5 results)
Research Products
(25 results)