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Chemical imaging using secondary ion mass spectrometry considering matrix effects

Research Project

Project/Area Number 17K05908
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Analytical chemistry
Research InstitutionSeikei University

Principal Investigator

AOYAGI Satoka  成蹊大学, 理工学部, 教授 (20339683)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsTOF-SIMS / マトリックス効果 / 有機EL材料 / ペプチド / 脂質 / 有機物 / 定量分析 / 質量分析 / 有機EL / L1正則化 / 二次イオン質量分析 / 分析科学 / 生体分子 / 生物物理 / 生物・生体工学 / 表面・界面物性
Outline of Final Research Achievements

Although time-of-flight secondary ion mass spectrometry (TOF-SIMS) is one of the most powerful methods to obtain detailed chemical information and molecular mappings with a high spatial resolution approximately 100 nm, quantitative analysis is still often challenging because the intensity change of a secondary ion can be suppressed or enhanced due to matrix effects by co-existing materials. Matrix effects are also important issues in dynamic-SIMS, and sensitivity factors (RSFs), which are obtained from reference samples in a narrow concentration range, are used to correct the measured secondary ion intensities influenced by matrix effects. In this study, matrix effects in positive and negative secondary ion spectra for biomolecules, antioxidants, and organic electroluminescence materials were investigated. As a result, it was suggested that correction methods based on RSF are also useful for TOF-SIMS spectra and images of organic samples.

Academic Significance and Societal Importance of the Research Achievements

物質ごとに分布情報が得られる質量イメージング分野の中でも空間分解能が高いことから注目されているTOF-SIMSについて、マトリックス効果が補正できることを示した。物質のイメージングは、測定単位ごとの定量分析に基づいて得られる情報であるため、マトリックス効果が補正可能であることを示した学術的および社会的意義は大きい。有機物および生体試料の2次元および3次元イメージングにおいて、より正確な計測結果が得られることが期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (18 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (8 results) Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 3 results)

  • [Int'l Joint Research] Justus-Liebig Universitate Giessen/Institute of Applied Physics(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] National Physical Laboratory(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Justus Liebig University Giessen(ドイツ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] National Physical Laboratory(英国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] National Physical Laboratory(英国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Justus-Liebig-Universitat Giessen(ドイツ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Justus-Liebig-Universitat Giessen(ドイツ)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] National Physical Laboratory(英国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Evaluation of Time-of-Flight Secondary Ion Mass Spectrometry Spectra of Peptides by Random Forest with Amino Acid Labels: Results from a Versailles Project on Advanced Materials and Standards Interlaboratory Study2021

    • Author(s)
      Satoka Aoyagi, Yukio Fujiwara, Akio Takano, Jean-Luc Vorng, Ian S. Gilmore, Yung-Chen Wang, et al.
    • Journal Title

      Analytical chemistry

      Volume: 93 Issue: 9 Pages: 4191-4191

    • DOI

      10.1021/acs.analchem.0c04577

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigating matrix effects of different combinations of lipids and peptides on TOF-SIMS data2020

    • Author(s)
      Keisuke Mizomichi, Takayuki Yamagishi, Tomoko Kawashima, Michael Durr, and Satoka Aoyagi
    • Journal Title

      Biointerphases

      Volume: 15 Issue: 2 Pages: 021008-021008

    • DOI

      10.1116/6.0000036

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] OrbiSIMS imaging identifies molecular constituents of the perialgal vacuole membrane of Paramecium bursaria with symbiotic Chlorella variabilis2019

    • Author(s)
      Satoka Aoyagi, Yuuki Kodama, Melissa K. Passarelli, Jean-Luc Vorng, Tomoko Kawashima, Keisuke Yoshikiyo, Tatsuyuki Yamamoto and Ian S. Gilmore
    • Journal Title

      Analytical Chemistry

      Volume: 91 Issue: 22 Pages: 14545-14551

    • DOI

      10.1021/acs.analchem.9b03571

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of matrix effects on TOF-SIMS data of leu-enkephalin and 1,2-dioleoyl-sn-glycero-3-phosphocholine mixed samples2018

    • Author(s)
      Shusuke Nakano, Takayuki Yamagishi, and Satoka Aoyagi, Andre Portz, Michael Durr, Hideo Iwai, Tomoko Kawashima
    • Journal Title

      Biointerphases

      Volume: 13 Issue: 3

    • DOI

      10.1116/1.5013219

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Soft depth-profiling of mixed peptide/lipid samples by means of cluster induced desorption/ionization mass spectrometry―High depth resolution and low matrix effect2018

    • Author(s)
      Andre Portz, Satoka Aoyagi, Michael Durr
    • Journal Title

      Biointerphases

      Volume: 13 Issue: 3

    • DOI

      10.1116/1.5013151

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 二種類の有機物質積層試料の TOF-SIMSデプスプロファイルにおける情報エントロ ピーを利用した界面評価2020

    • Author(s)
      溝道桂介,山ぎし崇之,青柳里果
    • Organizer
      日本表面真空学会学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 有機 EL材料混合試料の TOF-SIMSスペクトルにおけるマトリックス効果の評価2020

    • Author(s)
      家持圭佑, 溝道桂介,三井所亜子, 山ぎし崇之,青柳里果
    • Organizer
      日本表面真空学会学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Investigating Matrix Effects on Different Combinations of Lipids and Peptides2019

    • Author(s)
      Keisuke Mizomichi, Takayuki Yamagishi, Tomoko Kawashima, Michael Durr, and Satoka Aoyagi
    • Organizer
      the 22nd International Conference on Secondary Ion Mass Spectrometry (SIMS 22)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sparse Modeling Application to Image Fusion Data of Plant Tissues using TOF-SIMS and Light Microscope2019

    • Author(s)
      Masaru Ito, Yukari Kuga, Takayuki Yamagishi, Miya Fujita, and Satoka Aoyagi
    • Organizer
      the 22nd International Conference on Secondary Ion Mass Spectrometry (SIMS 22)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of matrix effects on ToF-SIMS data of peptide and lipid mixed samples2017

    • Author(s)
      Shusuke Nakano, Takayuki Yamagishi1, Hideo Iwai, Satoka Aoyagi
    • Organizer
      the 21st International Conference on Secondary Ion Mass Spectrometry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2022-02-22  

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