New therapeutic strategy of Alzheimer's disease
| Project/Area Number |
17K07095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北尾 慎一郎 鳥取大学, 医学部, 助教 (60724804)
加藤 雅子 鳥取大学, 医学部, 准教授 (80221183)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アルツハイマー病 / 画期的新規治療薬 / アルツハイマー病早期発見 / キサンチン酸化還元酵素阻害剤 / 神経変性疾患 / アルツハイマー病早期発見装置 / アルツハイマー病新規治療薬 / 非プリン型キサンチン酸化還元酵素阻害剤 / プリン型キサンチン酸化還元酵素阻害剤 |
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| Outline of Final Research Achievements |
We elucidated the Alzheimer's disease (Alz) mice with mutant amyloid and tau protein genes.New therapeutic drug non-purine XORI: TEI-6720, a control drug purine type (p)XORI:allopurinol (Allop), and placebo: methyl cellulose (MC) were used.In an epoch-making simple cognitive evaluation system, the Alz mice of the both the Allop and the MC groups showed dementia. By contrast, the Alz mice of the TEI-6720 group significantly improved dementia. Pathological analyses demonstrated that TEI-6720 group showed significantly decreases of both the NFT and the large SP, in a comparison with Allop group or the MC group.
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| Academic Significance and Societal Importance of the Research Achievements |
アルツハイマー病への臨床応用によりその効果が確認されれば、患者と介護する家族への貢献度は極めて大である。また、国民の医療・福祉の向上に直接結びつき、社会的貢献度は極めて大きい。更に、社会への経済波及効果は計り知れない。
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Report
(4 results)
Research Products
(26 results)
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[Presentation] In order to keep neuropathology succession, teaching stuffs of neuropathology should deal with neuroanatomy, clinical clerkship, and clinical office for outpatients, as well as neuropathology.2018
Author(s)
Kato S, Kitao S, Ii M, Kohama H, Yonekura K, Kaida Y, Itaki N, Yasui J, Oda K, Kato K
Organizer
ICN2018: 19th International Neuropathology of Congress
Related Report
Int'l Joint Research
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