| Project/Area Number |
17K07095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北尾 慎一郎 鳥取大学, 医学部, 助教 (60724804)
加藤 雅子 鳥取大学, 医学部, 准教授 (80221183)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アルツハイマー病 / 画期的新規治療薬 / アルツハイマー病早期発見 / キサンチン酸化還元酵素阻害剤 / 神経変性疾患 / アルツハイマー病早期発見装置 / アルツハイマー病新規治療薬 / 非プリン型キサンチン酸化還元酵素阻害剤 / プリン型キサンチン酸化還元酵素阻害剤 |
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| Outline of Final Research Achievements |
We elucidated the Alzheimer's disease (Alz) mice with mutant amyloid and tau protein genes.New therapeutic drug non-purine XORI: TEI-6720, a control drug purine type (p)XORI:allopurinol (Allop), and placebo: methyl cellulose (MC) were used.In an epoch-making simple cognitive evaluation system, the Alz mice of the both the Allop and the MC groups showed dementia. By contrast, the Alz mice of the TEI-6720 group significantly improved dementia. Pathological analyses demonstrated that TEI-6720 group showed significantly decreases of both the NFT and the large SP, in a comparison with Allop group or the MC group.
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| Academic Significance and Societal Importance of the Research Achievements |
アルツハイマー病への臨床応用によりその効果が確認されれば、患者と介護する家族への貢献度は極めて大である。また、国民の医療・福祉の向上に直接結びつき、社会的貢献度は極めて大きい。更に、社会への経済波及効果は計り知れない。
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