Mechanism of activity-dependent motor improvement in SCA
| Project/Area Number |
17K07103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Gunma University |
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Principal Investigator |
Hosoi Nobutake 群馬大学, 大学院医学系研究科, 准教授 (90543570)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 小脳 / baclofen / GABAb受容体 / 活動依存的 / 脊髄小脳失調症 / プルキンエ細胞 / ＧＡＢＡｂ受容体 / リハビリ |
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| Outline of Final Research Achievements |
In this study, I focused on congenital spinocerebellar ataxia (SCA) which is characterized by cerebellar dysfunction, and the purpose of the study was examining the mechanism by which oral administration of low-dose baclofen may improve motor performance of SCA model mice in an activity-dependent manner. To this end, I tried to develop a technique for activity-dependent labeling of cerebellar neurons, but it turned out to be difficult because of the unstableness and the low efficiency of activity-dependent labeling in the cerebellum. The effect of low-dose baclofen on cerebellar function was examined, and the results suggest that baclofen might act on the brain regions other than the cerebellum to improve motor performance of SCA3 model mice.
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| Academic Significance and Societal Importance of the Research Achievements |
脊髄小脳失調症（SCA）は、治療法として対症療法しかない難病指定の希少疾患であるため、SCAの治療法に関する研究は大きな社会的意義がある。小脳神経細胞を活動依存的にラベリングする新しい手法の適用はうまくいかなかったものの、SCA３モデルマウスでは、低濃度バクロフェンの作用が小脳以外のところで作用して運動機能の改善に関与する可能性を得られたことは、学術的にも意義があると思われる。
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Report
(6 results)
Research Products
(19 results)
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[Journal Article] Protein kinase Cγ in cerebellar Purkinje cells regulates Ca 2+-activated large-conductance K + channels and motor coordination2022
Author(s)
Watanave M, Takahashi N, Hosoi N, Konno A, Yamamoto H, Yasui H, Kawachi M, Horii T, Matsuzaki Y, Hatada I, Hirai H.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 119(7)
Issue: 7
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The neurotoxic effect of lactational PFOS exposure on cerebellar functional development in male mice2022
Author(s)
Ninomiya A, Mshaty A, Haijima A, Yajima H, Kokubo M, Khairinisa MA, Ariyani W, Fujiwara Y, Ishii S, Hosoi N, Hirai H, Amano I, Koibuchi N.
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Journal Title
Food Chem Toxicol
Volume: 159:112751
Pages: 112751-112751
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments.2019
Author(s)
Hosoi N, Shibasaki K, Hosono M, Konno A, Shinoda Y, Kiyonari H, Inoue K, Muramatsu SI, Ishizaki Y, Hirai H, Furuichi T, Sadakata T
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Journal Title
J Neurosci
Volume: 39(32)
Issue: 32
Pages: 6339-6353
DOI
Related Report
Peer Reviewed
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