| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
It was shown that localization of mrg-1 mRNA to primordial germ cells may not be caused by active RNA degradation in somatic cells, but by specific stabilization of mRNA in primordial germ cells. This RNA stability control that mrg-1 3'UTR undergoes seems to be a sequence-dependent control that does not involve RNA secondary structure. It is also suggested that the tropomyosin protein LEV-11 contributes to the regulation of mRNA stabilization through its interaction with the mrg-1 3'UTR in primordial germ cells. Moreover, the phenotype of mutants that do not express MRG-1 in somatic cells suggests that MRG-1 may also contribute to chromatin regulation in some somatic cells.
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