Studies on saprophytic, parasitic and symbiotic strategies depending on secondary metabolite production in necrotrophic plant pathogens
Project/Area Number |
17K07666
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Plant protection science
|
Research Institution | Tottori University |
Principal Investigator |
Kodama Motoichiro 鳥取大学, (連合)農学研究科(研究院), 教授 (00183343)
|
Co-Investigator(Kenkyū-buntansha) |
石原 亨 鳥取大学, 農学部, 教授 (80281103)
|
Project Period (FY) |
2017-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 植物病原菌 / 腐生菌 / 共生菌 / 二次代謝産物 / ゲノミクス / 遺伝子クラスター / ネクロトロフ |
Outline of Final Research Achievements |
As a result of coevolution with plants, phytopathogenic fungi have developed the ability to produce a wide variety of secondary metabolites (SM). These compounds contribute to the differentiation of pathogenicity as effector molecules in pathogenic fungi, and as survival and pathogenicity strategies in fungi, as well as in saprophytic (non-pathogenic), symbiotic and pathogenic fungi. Through comparative and phylogenomic analyses using various filamentous fungi with different lifestyles, it has been shown that clusters of SM biosynthetic genes play an important role in the survival and pathogenicity strategies of necrotrophic pathogens, saprophytic fungi, and symbiotic fungi, as well as in the process of diversity formation and evolution. In addition, we revealed the possibility that horizontal transfer of gene clusters and pathogenic chromosomes may be involved.
|
Academic Significance and Societal Importance of the Research Achievements |
A. alternata菌群は、腐生菌から共生菌、さらに高度に分化した寄生菌まで幅広く包含するユニークなグループであり、菌の腐生性および寄生性の全体像を理解するための特色ある対象生物である。この特性を最大限に活用し、糸状菌の特質でもある多彩なSM生合成系をターゲットにして、菌の生存・発病戦略の分子機構、多様性および進化を包括的に解析することが可能となった。腐生生活においても重要である二次代謝系の分子機構が解明されれば、寄生菌コントロールの一環として、腐生生活環をターゲットにするという全く新規な応用研究分野が創出され、そのインパクトは大である。
|
Report
(5 results)
Research Products
(34 results)
-
-
-
-
-
-
-
-
[Journal Article] Natural variation in the expression and catalytic activity of a naringenin 7-O-methyltransferase influences antifungal defenses in diverse rice cultivars2020
Author(s)
Koichi Murata, Takashige Kitano, Riko Yoshimoto, Ryo Takata, Naoki Ube, Kotomi Ueno, Makoto Ueno, Yukinori Yabuta, Masayoshi Teraishi, Cynthia K. Holland, Georg Jander, Yutaka Okumoto, Naoki Mori, Atsushi Ishihara
-
Journal Title
The Plant Journal
Volume: 101
Issue: 5
Pages: 1103-1117
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
[Journal Article] Molecular characterization of a novel mycovirus in Alternaria alternata manifesting two-sided effects: down-regulation of host growth and up-regulation of host plant pathogenicity.2018
Author(s)
Okada R, Ichinose S, Takeshita K, Urayama S, Fukuhara T, Komatsu K, Arie T, Ishihara A, Egusa M, Kodama M, Moriyama H(責任著者)
-
Journal Title
Virology
Volume: 458
Pages: 265-273
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Focused genome mining of structurally related sesterterpenes: enzymatic formation of enantiomeric and diastereomeric products2017
Author(s)
Narita, K., Sato, H., Minami, A., Kudo, K., Gao, L., Liu, C., Ozaki, T., Kodama, M.., Lei, X., Taniguchi, T., Monde, K., Yamazaki, M., Uchiyama, M., Oikawa, H.
-
Journal Title
Organic letters
Volume: 19
Issue: 24
Pages: 6696-6699
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
[Presentation] Genetic diversity and secondary metabolite biosynthetic potential of Epichloeendophytes isolated from Elymus species in various parts of Japan2019
Author(s)
Naori Izu, Hitoshi Tsujimoto, Wayne R. Simpson, Richard D. Johnson, Yasunori Akagi, Atsushi Ishihara, Motoichiro Kodama
Organizer
International Symposium on Agricultural, Food, Environmental, and Life Sciences in Asia, 2019 (AFELiSA 2019)
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-