Intracellular phospholipid transport and robustness of biological membrane in yeast
| Project/Area Number |
17K07710
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Fukuda Ryouichi 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (50323481)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | Saccharomyces cerevisiae / Yarrowia lipolytica / リン脂質 / 輸送 / 脂質輸送タンパク質 / Sec14ファミリータンパク質 / 膜コンタクトサイト / 酵母 / 生体膜 |
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| Outline of Final Research Achievements |
The intracellular transport of phospholipids contributes to the generation of the diversity of phospholipid species and to the maintenance of membrane homeostasis. Our results suggest that the lipid transfer protein is involved in inter-organelle phospholipid transport in the model yeast Saccharomyces cerevisiae. In addition, lipid transfer proteins were found to be involved in hyphal growth in response to n-alkanes in the n-alkane-assimilating dimorphic yeast Yarrowia lipolytica.
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| Academic Significance and Societal Importance of the Research Achievements |
真核生物におけるオルガネラ間の脂質輸送は細胞生物学的に重要な課題であるにもかかわらず解析の遅れた分野である。本研究において得られた酵母におけるリン脂質輸送に関する知見は、真核細胞内の脂質の動態と生体膜の形成機構の理解に大きく貢献するものである。また、本研究で得られた知見は、酵母を用いた有用脂質生産系の構築に寄与するだけでなく、様々な菌類を用いた脂質生産に拡張できる基盤を提供すると期待される。
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Report
(4 results)
Research Products
(11 results)
