Synthetic studies of biologically active natural products with unique structures ~ developments of new drug leads
| Project/Area Number |
17K07772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Okayama University |
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Principal Investigator |
Kiyota Hiromasa 岡山大学, 環境生命科学研究科, 教授 (30234397)
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| Co-Investigator(Kenkyū-buntansha) |
泉 実 岡山大学, 環境生命科学研究科, 准教授 (90379719)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 全合成 / limonoids / enacyloxins / maoecrystal V / sanctolide A / greensporones / 構造決定 / 天然物 / モモ / マオエクリスタルＶ / サンクトリドＡ / テレパミド / エナシロキシン / コルチスタチンＡ / 抗生物質 / xylomexicanin / enacyloxin / 単離構造決定 / thelepamide / 有機合成化学 / 生物活性 / 植物 / 創薬 |
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| Outline of Final Research Achievements |
Natural organic compounds and derivatives having a unique structure and biological activity have been used as pesticides, medicines, or prototypes thereof. In this study, we succeeded in isolating novel structures of terpenoids with antitumor activity etc. form the Chinese yew, mangrove, and herb. Furthermore, we conducted synthetic studies on the plant component maoecrystal V, the antibiotic enacyloxins, the marine substances telepamide, clionnamines, greensporones, sanctolide A, cortistatin A, etc., and achieved total synthesis or the synthesis of key intermediates. We have also succeeded in synthesizing sulfosialic acids, which are lead candidates for antiinfluenza drugs.
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| Academic Significance and Societal Importance of the Research Achievements |
医農薬の開発が頭打ちになっている現在、新規な薬剤開発の指標となる新規な骨格化合物の発見は極めて重要である。本研究では、植物から新規なリモノイド等を発見した。また、抗腫瘍物質マオエクリスタルVや抗生物質エナシロキシン、海洋物質サンクトライドAなど天然物の全合成研究においても、新規構造の化合物を多数合成することに成功した。これら新規化合物は、様々な生物活性試験を経て、有用な医農薬開発の指標となると期待できる。
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Report
(4 results)
Research Products
(78 results)
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[Journal Article] Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids2019
Author(s)
Christopher J. Vavricka, Takanobu Yoshida, Yuki Kuriya, Shunsuke Takahashi, Teppei Ogawa, Fumie Ono, Kazuko Agari, Hiromasa Kiyota, Jianyong Li, Jun Ishii, Kenji Tsuge, Hiromichi Minami, Michihiro Araki, Tomohisa Hasunuma, Akihiko Kondo
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Journal Title
Nature Communications
Volume: 10
Issue: 1
Pages: 2015-2015
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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