Effects of marginal zinc deficiency on parenting behavior and hormone secretion in pregnant rats.
| Project/Area Number |
17K07789
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Miyagi Gakuin Women's University |
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Principal Investigator |
Goto Tomoko 宮城学院女子大学, 生活科学部, 教授 (00342783)
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| Co-Investigator(Kenkyū-buntansha) |
白川 仁 東北大学, 農学研究科, 教授 (40206280)
駒井 三千夫 東北大学, 農学研究科, 名誉教授 (80143022)
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 亜鉛欠乏 / 妊娠期 / ラット / 育児行動 / ホルモン分泌 |
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| Outline of Final Research Achievements |
It is recommended to increase zinc intake during pregnancy. We investigated the effects of marginal zinc deficiency on parenting behavior and hormone secretion during pregnancy by feeding pregnant rats either a zinc-supplemented diet (Zn-Suf) or a low zinc diet (Low-Zn). Body surface temperature during pregnancy was significantly lower in the Low-Zn group compared to the Zn-Suf group. Some individuals in the Low-Zn group exhibited parental abandonment-like behavior. After childbirth, plasma corticosterone concentrations were significantly higher, and plasma oxytocin concentrations tended to be lower in the Low-Zn group. Marginal zinc deficiency during pregnancy may have caused a stress response, and decreased oxytocin secretion may have contributed to parental abandonment-like behavior.
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| Academic Significance and Societal Importance of the Research Achievements |
亜鉛は胎児の発育にも必須であり妊娠期に摂取量を増やすことが推奨されるが、悪阻等で妊娠期の潜在的亜鉛欠乏は多いと考えられる。本研究では妊娠期の潜在的亜鉛欠乏が出産後の育児行動・血漿中ホルモン濃度に及ぼす影響を検討した。その結果、妊娠期の潜在的亜鉛欠乏により生じるストレス応答やオキシトシン分泌低下が育児放棄様行動の一因となる可能性が考えられ、妊娠期における亜鉛栄養状態の重要性を示す成果であると考えている。また、妊娠期の体表温度は、低亜鉛食給餌2～4日目より速やかに有意に低下した。したがって、非侵襲的に潜在的亜鉛欠乏を鋭敏に追跡する指標として体表温度に注目した点に学術的意義があるものと考えている。
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Report
(7 results)
Research Products
(52 results)
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[Journal Article] Biotin Enhances Testosterone Production in Mice and Their Testis-Derived Cells2022
Author(s)
Shiozawa K, Maeda M, Ho H-J, Katsurai T, Howlader MZH, Horiuchi K, Sugita Y, Ohsaki Y, Agista AZ, Goto T, Komai M, Shirakawa H
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Journal Title
Nutrients
Volume: 14
Issue: 22
Pages: 4761-4761
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Tryptamine, a Microbial Metabolite in Fermented Rice Bran Suppressed Lipopolysaccharide-Induced Inflammation in a Murine Macrophage Model2022
Author(s)
Agista AZ, Tanuseputero SA, Koseki T, Ardiansyah, Budijanto S, Sultana H, Ohsaki Y, Yeh C-L, Yang S-C, Komai K, Shirakawa H
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Journal Title
International journal of molecular sciences
Volume: 23
Issue: 19
Pages: 11209-11209
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Zinc deficiency causes delayed ATP clearance and adenosine generation in rats and cell culture models.2018
Author(s)
Takeda TA, (Miyazaki S, Kobayashi M, Nishino K, Goto T, Matsunaga M, Ooi M, Shirakawa H, Tani F, Kawamura T, Komai M, Kambe T)
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Journal Title
Communications Biology
Volume: 1:113
Issue: 1
Pages: 1-13
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genotyping Analysis of Bitter-Taste Receptor Genes <i>TAS2R38</i> and <i>TAS2R46</i> in Japanese Patients with Gastrointestinal Cancers2017
Author(s)
Yamaki M, (Saito H, Isono K, Goto T, Shirakawa H, Shoji N, Satoh-Kuriwada S, Sasano T, Okada R, Kudoh K, Motoi F, Unno M, Komai M)
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 63
Issue: 2
Pages: 148-154
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access
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[Presentation] 東北メディカル・メガバンクのリファレンスパネルを利用した苦味受容体の個人差と味嗜好性との関連2018
Author(s)
八巻美智子, (三森隆弘, 小野彰, 鈴木洋一, 長崎正朗, 山本雅之,佐藤しづ子, 庄司憲明, 齋藤弘貴, 磯野邦夫, 後藤知子, 白川仁, 駒井三千夫)
Organizer
日本味と匂学会第52回大会
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