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Study of intestinal oleoylethanolamide on regulation of satiety and prevention of lifestyle-related disease

Research Project

Project/Area Number 17K07809
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionTokyo University of Agriculture and Technology (2018-2019)
Institute of Physical and Chemical Research (2017)

Principal Investigator

Igarashi Miki  東京農工大学, (連合)農学研究科(研究院), 特任准教授 (70340172)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsオレオイルエタノールアミド / 腸管 / 肥満 / 食欲 / 生活習慣病 / オレイン酸 / 摂食行動 / 脂質 / 脂肪酸
Outline of Final Research Achievements

In this study, we investigated the biosynthetic pathway and regulation mechanism of intestinal oleoylethanolamide (OEA), a satiety factor. As the results, we found (1) the major pathway of intestinal OEA synthesis using in vitro system. In addition, we revealed that (2) the importance of dietary oleic acid, and (3) the involvement of bile acids, such as deoxycholic acid, and insulin signal on intestinal OEA synthesis using mice.

Academic Significance and Societal Importance of the Research Achievements

本研究では、食事脂質やエネルギー摂取のインバランスによって食後満足感誘導物質であるOEAの生合成が減少するということを見出した。食後満足感が得られなければ、更なる摂食が起こるため過食となる。本研究から得られた結果と合わせて考えると、質の良い食事脂質や程よいエネルギー摂取を心がけることで、OEAの生合成を促して食後満足感を誘導することで過剰なエネルギー摂取が予防できる可能性がある。肥満をはじめとする生活習慣病予防の一助となる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results)

  • [Journal Article] NAPE-PLD controls OEA synthesis and fat absorption by regulating lipoprotein synthesis in an in vitro model of intestinal epithelial cells2019

    • Author(s)
      Miki Igarashi、Kazuhide Watanabe、Tsuyoshi Tsuduki、Ikuo Kimura、Naoto Kubota
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 3 Pages: 3167-3179

    • DOI

      10.1096/fj.201801408r

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] N-acyl-phosphatidylethanolamine-specific phospholipase D regulates oleoylethanolamide and lipoprotein synthesis in an in vitro model of intestinal epithelial cells2019

    • Author(s)
      Igarashi, M., K. Watanabe, T. Tsuduki, I. Kimura
    • Organizer
      60th -International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dietary oleic acid modulates feeding behavior by controlling OEA response2019

    • Author(s)
      Igarashi, M., K. Iwasa, K. Yoshikawa, T. Tsuduki, I. Kimura.
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Importance of intestinal OEA signaling on lipid absorption and feeding behavior2019

    • Author(s)
      Igarashi, M.
    • Organizer
      International Conference on Food Factors 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effects of dietary oleic acid on jejunal OEA response and feeding behavior2019

    • Author(s)
      Igarashi, M.
    • Organizer
      Fatty Acids in Cell Signaling 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Disruption of intestinal OEA synthesis by imbalanced consumption of fat and carbohydrate affects feeding behavior2019

    • Author(s)
      Miki Igarashi, Kensuke Iwasa, Keisuke Yoshikawa, Tsuyoshi Tsuduki
    • Organizer
      keystone symposia
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impaired production of an intestinal satiety factor OEA by imbalanced consumption of fat and carbohydrate2018

    • Author(s)
      Miki Igarashi, Kensuke Iwasa, Keisuke Yoshikawa, Daniele Piomelli
    • Organizer
      International Society for the Study of Fatty Acids and Lipids
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impaired production of an intestinal satiety factor OEA by imbalanced consumption of fat and carbohydrate2018

    • Author(s)
      Miki Igarashi, Kensuke Iwasa, Keisuke Yoshikawa, Tsuyoshi Tsuduki, Daniele Piomelli
    • Organizer
      ISSFAL2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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