| Project/Area Number |
17K08121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
Shibata Hideshi 東京農工大学, (連合)農学研究科(研究院), 教授 (50145190)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 大腸 / ウサギ / 腸神経系 / 腸壁 / 構造 / 大腸壁 / 胃 / 粘液細胞 / 筋層間神経叢 / 近位結腸 / 遠位結腸 / 結腸紡錘 / 獣医学 / 解剖学 / 神経科学 / 細胞・組織 |
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| Outline of Final Research Achievements |
The present study clarified the structural features of the wall and nervous tissues in each segment of the rabbit large intestine. The fusus coli and rectum have the thickest intestinal wall, followed by the proximal colon and distal colon, and the cecum has the thinnest wall. The fusus coli has the thickest mucosa whereas the rectum has the thickest muscular layer. Furthermore, the fusus coli has the most numerous mucous cells whereas the cecum has the fewest. The enteric nervous tissue is the richest in the proximal colon, followed by the fusus coli, distal colon, and cecum. Some neurochemical substances are distributed in a similar fashion. These findings suggest that the proximal colon may control complex bowel motility with the most well-developed neuronal network, the fusus coli may secrete rich mucus that enwraps the soft feces, and the cecum may gently contract for fermentation of the cecal contents with the least developed wall and nerve plexus.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によって，盲腸糞の形成という特異な消化機構を有するウサギにおける大腸壁の構築と腸管運動を制御する腸神経系の構築が明らかになった．これらの結果は，近年，伴侶動物として飼育数が増加しているウサギに多発する消化管疾患の治療法の開発においても，その基盤となる基礎獣医学的知見となった．
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