| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this study, we used the organelle-specific Fe2 + fluorescent probe to visualize Fe2+ kinetics and elucidate the relationship between the perturbation of intracellular iron dynamics caused by the PD causative gene and the PD pathogenesis mechanism in order to develop a new drug discovery platform for PD. We have been able to clarify the disruption of Fe2+ dynamics caused by VPS35 and ATP13A2 knockdown. Moreover, it was clarified that the disturbance of Fe2+ dynamics caused by VPS35 knockdown was improved by R55, a retromer stabilizer.
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