| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
A novel choline transporter-like protein 1 (CTL1) was found to be highly expressed in cancer cells, and its inhibition induced apoptosis and suppressed cell growth. Furthermore, the search for CTL1 inhibitors from existing pharmaceutical and plant-derived organic compound libraries led to the discovery of promising isoquinoline derivatives. This hit compound may be a candidate for a new molecularly targeted cancer drug with a novel therapeutic mechanism.
|
