The host immune responses influenced by resident microbiota
Project/Area Number |
17K08389
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Environmental and hygienic pharmacy
|
Research Institution | Nagoya City University |
Principal Investigator |
Hida Shigeaki 名古屋市立大学, 医薬学総合研究院(薬学), 教授 (10345762)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | アレルギー / 毒素 / サイトカイン / 炎症 / 細菌 / 自然免疫細胞 / シグナル伝達 / 常在細菌 / 免疫 / 免疫学 / アレルギー・ぜんそく / 生体分子 |
Outline of Final Research Achievements |
Mast cells and basophils have recently been recognized as an effectors of type 2 immune responses in response to various antigen-specific IgE. Staphylococcus aureus (S. aureus) bacteria is a common pathogen. It colonizes approximately 30% of the population asymptomatically, but may cause a variety of inflammatory diseases such as allergy. We found that S. aureus-derived alpha-hemolysin and SSL12 evokes the degranulation and cytokine production by mast cells without cell membrane damage. These findings indicate bacteria-derived molecules likely play important roles in both initiation phase and effector phase of allergic and type 2-immune responses.
|
Academic Significance and Societal Importance of the Research Achievements |
本研究課題では環境因子による自然免疫細胞群の活性化と免疫バランスには偏りが生じうること、そしてそれが各種免疫疾患のQOLに影響することに注目した。これまで不明であった細菌と宿主免疫細胞の相互作用を明らかにする研究から、疾患の基礎研究と常在細菌の分類や性質を解析することによって、感染症や免疫反応の理解と臨床薬学への応用が本研究の成果として期待される。また、本研究課題の解析により、免疫細胞や組織細胞の制御をターゲットにした新規免疫制御方法の開発が可能となり、これまでの治療法に加えたアレルギー,自己免疫疾患,感染防御の新規治療,予防法の開発に対して指針を与えることにつながる。
|
Report
(4 results)
Research Products
(23 results)
-
[Journal Article] Bidirectional Crosstalk Between Neutrophils and Adipocytes Promotes Adipose Tissue Inflammation2019
Author(s)
Watanabe Y, Nagai Y, Honda H, Okamoto N, Yanagibashi T, Ogasawara M, Yamamoto S, Imamura R, Takasaki I, Hara H, Sasahara M, Arita M, Hida S, Taniguchi S, Suda T, Takatsu K.
-
Journal Title
FASEB J.
Volume: 33(11)
Issue: 11
Pages: 11821-11835
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] 5-Hydroxy-2-methylpyridine Isolated from Cigarette Smoke Condensate Aggravates Collagen-Induced Arthritis in Mice2018
Author(s)
Masafumi Takeno, Shinya Kitagawa, Junpei Yamanaka, Mayumi Teramoto, Haruka Tomita, Naohiro Shirai, Saotomo Itoh, Shigeaki Hida, Kazuichi Hayakawa, Kikuo Onozaki, Takemasa Takii
-
Journal Title
Biological and Pharmaceutical Bulletin
Volume: 41
Issue: 6
Pages: 877-884
DOI
NAID
ISSN
0918-6158, 1347-5215
Year and Date
2018-06-01
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-